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Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2014, Volume 88, Issue 1, pp. 36 - 45
Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) metabolises steroid hormones, prostaglandins and xenobiotics, and activates the dinitrobenzamide mustard prodrug... 
Aldo-keto reductase 1C3 | Fluorogenic assays | PR-104 | SN34037 | Leukaemia | INDUCTION | HYPOXIA | IDENTIFICATION | CANCER | A549 CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENES | AKR1C ENZYMES | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOTOXICITY | Humans | Nitrogen Mustard Compounds - pharmacokinetics | Substrate Specificity | Fluorometry - methods | Bone Marrow - enzymology | Hydroxyprostaglandin Dehydrogenases - metabolism | Leukocytes - enzymology | Prodrugs - metabolism | Urea - chemistry | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Time Factors | Enzyme Inhibitors - chemistry | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Aerobiosis | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Nitrogen Mustard Compounds - pharmacology | HCT116 Cells | Heterocyclic Compounds, 4 or More Rings - chemistry | Morpholines - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Morpholines - chemistry | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Prodrugs - pharmacokinetics | Aldo-Keto Reductase Family 1 Member C3 | Nitrogen Mustard Compounds - metabolism | Heterocyclic Compounds, 4 or More Rings - metabolism | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Prodrugs - pharmacology | Drug Resistance, Neoplasm - drug effects | Leukemia
Journal Article
Haematologica, ISSN 0390-6078, 07/2015, Volume 100, Issue 7, pp. 927 - 934
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs.... 
STEM-CELLS | INHIBITION | PR-104A | ACUTE MYELOGENOUS LEUKEMIA | BONE-MARROW | I TRIAL | KETO REDUCTASE 1C3 | HIF-1-ALPHA | HEMATOLOGY | CANCER-THERAPY | CHEMOTHERAPY | Recurrence | Humans | Middle Aged | Male | Antineoplastic Agents, Alkylating - administration & dosage | Carbonic Anhydrases - metabolism | Thrombocytopenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Anemia - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Bone Marrow - metabolism | Enterocolitis - genetics | Antigens, Neoplasm - metabolism | Bone Marrow - drug effects | Biomarkers - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications | Gene Expression | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Leukemia, Myeloid, Acute - pathology | Anemia - chemically induced | Hypoxia - complications | Thrombocytopenia - chemically induced | Thrombocytopenia - pathology | Nitrogen Mustard Compounds - adverse effects | Remission Induction | Hypoxia - pathology | Antineoplastic Agents, Alkylating - adverse effects | Enterocolitis - pathology | Prodrugs - administration & dosage | Hypoxia - drug therapy | Neutropenia - metabolism | Nitrogen Mustard Compounds - administration & dosage | Carbonic Anhydrases - genetics | Anemia - pathology | Leukemia, Myeloid, Acute - complications | Prodrugs - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neutropenia - pathology | Adult | Female | Neutropenia - chemically induced | Neutropenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Carbonic Anhydrase IX | Enterocolitis - chemically induced | Antigens, Neoplasm - genetics | Nitroimidazoles - pharmacology | Thrombocytopenia - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Anemia - metabolism | Prodrugs - adverse effects | Hypoxia - genetics | Nitrogen Mustard Compounds - metabolism | Bone Marrow - pathology | Aged | Enterocolitis - metabolism | Antineoplastic Agents, Alkylating - metabolism | Leukemia, Myeloid, Acute - genetics
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 4, pp. 1573 - 1584
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12865 - 12870
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2009, Volume 8, Issue 6, pp. 1714 - 1723
Journal Article
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2015, Volume 308, Issue 4, pp. F330 - F338
Chronic lymphatic leukemia (CLL) is often associated with nephritic syndrome. Effective treatment of CLL by chlorambucil and bendamustine leads to the... 
Chlorambucil | Uptake transporter | Chronic lymphocytic leukemia | Bendamustine | Cytostatics | Solute carrier family 22 | Organic anion transporter | PHYSIOLOGY | solute carrier family 22 | organic anion transporter | uptake transporter | cytostatics | IDENTIFICATION | chronic lymphocytic leukemia | PROFILE | ALKYLATING-AGENTS | UROLOGY & NEPHROLOGY | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | OLD DRUG | KIDNEY INVOLVEMENT | chlorambucil | MELPHALAN | bendamustine | HUMAN BILE | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transport Protein 1 - metabolism | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Apoptosis - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Chlorambucil - pharmacology | Lymphoma, T-Cell - metabolism | Dose-Response Relationship, Drug | Transfection | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | p-Aminohippuric Acid - metabolism | Melphalan - metabolism | Melphalan - pharmacology | Tumor Cells, Cultured | Chlorambucil - metabolism | Organic Anion Transport Protein 1 - antagonists & inhibitors | Jurkat Cells | Nitrogen Mustard Compounds - pharmacology | Lymphoma, T-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Bendamustine Hydrochloride | Estrone - analogs & derivatives | Nitrogen Mustard Compounds - metabolism | Estrone - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Lymphoma, T-Cell - pathology | Cell Proliferation - drug effects | Antineoplastic Agents, Alkylating - metabolism | Protein research | Carrier proteins | Oncology, Experimental | Cancer cells | Physiological aspects | Disease susceptibility | Lymphomas | Research | Health aspects | Cancer
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2001, Volume 8, Issue 5, pp. 533 - 544
Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen... 
CHEMISTRY, MEDICINAL | DUOCARMYCIN SA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO TRANSCRIPTION | NITROGEN-MUSTARD | ANTITUMOR-ACTIVITY | BENZOIC-ACID MUSTARD | INTERSTRAND CROSS-LINKING | SEQUENCE PREFERENTIAL ALKYLATION | DIRECTED ANILINE MUSTARDS | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | SECO-CBI-TMI | Anthramycin - metabolism | Distamycins - metabolism | Antibiotics, Antineoplastic - pharmacology | Alkylating Agents - pharmacology | Humans | Cyclohexenes | Benzofurans - pharmacology | Structure-Activity Relationship | Nitrogen Mustard Compounds - chemistry | Netropsin - metabolism | Benzofurans - chemistry | Alkylating Agents - metabolism | Indoles - metabolism | Antibiotics, Antineoplastic - chemistry | Indoles - pharmacology | Cyclohexanecarboxylic Acids - metabolism | Chlorambucil - metabolism | DNA - drug effects | Bisbenzimidazole - metabolism | Chlorambucil - chemistry | Pyrroles - metabolism | Nitrogen Mustard Compounds - pharmacology | Bisbenzimidazole - chemistry | DNA - metabolism | Alkylating Agents - chemistry | Netropsin - analogs & derivatives | Anthramycin - pharmacology | Distamycins - chemistry | DNA - chemistry | Animals | Netropsin - chemistry | Cyclohexanecarboxylic Acids - pharmacology | Nitrogen Mustard Compounds - metabolism | Pyrroles - chemistry | Anthramycin - chemistry | Antibiotics, Antineoplastic - metabolism | Indoles - chemistry | Cyclohexanecarboxylic Acids - chemistry | Benzofurans - metabolism
Journal Article