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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 5935 - 5949
Drugs that target DNA topoisomerase II isoforms and alkylate DNA represent two mechanistically distinct and clinically important classes of anticancer drugs.... 
Etoposide | Hybrid | Topoisomerase II | K562 cells | Structure-based design | DNA | Molecular modeling | Nitrogen mustard | COMPARE | Docking | Anticancer | Alkylator | Epipodophyllotoxin | LEUKEMIA K562 CELLS | CANCER-THERAPY | STRAND BREAKS | DRUGS | PODOPHYLLOTOXIN | DERIVATIVES | DEXRAZOXANE ICRF-187 | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTITUMOR AGENTS | INHIBITORS | Podophyllotoxin - pharmacology | Leukemia - pathology | Mustard Compounds - pharmacology | Humans | Mustard Compounds - chemistry | DNA Breaks, Double-Stranded - drug effects | Neoplasms - genetics | Topoisomerase II Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Leukemia - genetics | DNA Topoisomerases, Type II - metabolism | Etoposide - analogs & derivatives | Leukemia - enzymology | Etoposide - pharmacology | Leukemia - drug therapy | Neoplasms - enzymology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | DNA - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Neoplasms - pathology | Podophyllotoxin - analogs & derivatives | Chemical properties | epipodophyllotoxin | alkylator | nitrogen mustard | structure-based design | anticancer | docking | topoisomerase II | hybrid | molecular modeling | etoposide
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2014, Volume 88, Issue 1, pp. 36 - 45
Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) metabolises steroid hormones, prostaglandins and xenobiotics, and activates the dinitrobenzamide mustard prodrug... 
Aldo-keto reductase 1C3 | Fluorogenic assays | PR-104 | SN34037 | Leukaemia | INDUCTION | HYPOXIA | IDENTIFICATION | CANCER | A549 CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENES | AKR1C ENZYMES | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOTOXICITY | Humans | Nitrogen Mustard Compounds - pharmacokinetics | Substrate Specificity | Fluorometry - methods | Bone Marrow - enzymology | Hydroxyprostaglandin Dehydrogenases - metabolism | Leukocytes - enzymology | Prodrugs - metabolism | Urea - chemistry | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Time Factors | Enzyme Inhibitors - chemistry | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Aerobiosis | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Nitrogen Mustard Compounds - pharmacology | HCT116 Cells | Heterocyclic Compounds, 4 or More Rings - chemistry | Morpholines - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Morpholines - chemistry | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Prodrugs - pharmacokinetics | Aldo-Keto Reductase Family 1 Member C3 | Nitrogen Mustard Compounds - metabolism | Heterocyclic Compounds, 4 or More Rings - metabolism | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Prodrugs - pharmacology | Drug Resistance, Neoplasm - drug effects | Leukemia
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2017, Volume 516, Issue 1-2, pp. 323 - 333
This paper aims to develop and evaluate a pH-sensitive PEGylated liposomal (pPSL) system for tumor-targeted intracellular delivery of SN25860, a weakly acidic,... 
pH-sensitive liposomes | Gene-directed enzyme-prodrug therapy | 1,2-dioleoy-sn-glycero-3-phosphoethanolamine | Hydroxypropyl-β-cyclodextrin | CID 44134771 | DOPE (CID 9546744) | Cholesterol | Endosome escape | DSPC (CID 94190) | 1,2-distearoyl-sn-glycero-3-phosphocholine | CID 406952 | 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[Methoxy(Polyethylene glycol)-2000] | CHEMS (CID 65082) | Active loading | Cholesteryl hemisuccinate | CID 5997 | DRUG | NITROREDUCTASE | DISCRIMINATION | THERAPEUTIC-EFFICACY | PHASE-TRANSITION | PHARMACOLOGY & PHARMACY | TUMOR-CELLS | FLOW-CYTOMETRY | WEAK ACIDS | ENDOCYTOSIS | STRATEGIES | Chromatography, High Pressure Liquid - methods | Benzamides - pharmacokinetics | Nitrogen Mustard Compounds - administration & dosage | Nitrogen Mustard Compounds - pharmacokinetics | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Endosomes - metabolism | Drug Delivery Systems | Benzamides - administration & dosage | Flow Cytometry | Transfection | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Prodrugs | Nitrogen Mustard Compounds - pharmacology | Solubility | Microscopy, Confocal | Mammary Neoplasms, Animal - pathology | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mammary Neoplasms, Animal - drug therapy | Mice | Liposomes | Hydrogen-Ion Concentration | Cancer
Journal Article
癌症:英文版, ISSN 1000-467X, 2014, Volume 33, Issue 2, pp. 80 - 86
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23108
Recent studies indicate that interactions between leukemia cells and the bone marrow (BM) microenvironment promote leukemia cell survival and confer resistance... 
INDUCIBLE FACTOR-1-ALPHA | BONE-MARROW MICROENVIRONMENT | CANCER-TREATMENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MYELOGENOUS LEUKEMIA | KETO REDUCTASE 1C3 | GENE-EXPRESSION | ACUTE MYELOID-LEUKEMIA | NF-KAPPA-B | Prodrugs - administration & dosage | Leukemia - pathology | Leukocyte Common Antigens - metabolism | Nitrogen Mustard Compounds - administration & dosage | Humans | Antineoplastic Agents - therapeutic use | Nitrogen Mustard Compounds - therapeutic use | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Bone Marrow - drug effects | Disease Models, Animal | Tumor Microenvironment - drug effects | Cell Hypoxia - drug effects | Nitrogen Mustard Compounds - pharmacology | Leukemia - drug therapy | Treatment Outcome | Remission Induction | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Models, Biological | Bone Marrow - pathology | Cell Line, Tumor | Mice | Prodrugs - therapeutic use | Prodrugs - pharmacology | Drug Resistance, Neoplasm - drug effects | Drugs | Pediatrics | Animal models | Leukemia | Xenotransplantation | Chemoresistance | Neuroblastoma | Drug resistance | Kinases | Cancer therapies | Immunosuppressive agents | Proteins | Signal transduction | Xenografts | Cell cycle | Bone marrow | Medical research | Acute lymphatic leukemia | Cell survival | Prodrugs | Cytokines | Hematology | Immunodeficiency | Lymphatic leukemia | Gene expression | Chemical compounds | Survival | Hemopoiesis | Children & youth | Chemotherapy | Biopsy | Cell lines | Stem cells | Hypoxia | Mustard | Niches | Tumors
Journal Article