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Current Drug Metabolism, ISSN 1389-2002, 10/2006, Volume 7, Issue 7, pp. 715 - 727
Journal Article
Cancer Research, ISSN 0008-5472, 09/2006, Volume 66, Issue 17, pp. 8731 - 8739
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 3, p. e33894
Current regimens for induction therapy of pediatric acute lymphoblastic leukemia (ALL), or for re-induction post relapse, use a combination of vincristine... 
DEXAMETHASONE | ASPARAGINASE | B-CELL PRECURSOR | SCID MICE | MULTIDISCIPLINARY SCIENCES | MIMETIC ABT-737 | VINCRISTINE | RESISTANCE | TERM-FOLLOW-UP | CHILDHOOD LEUKEMIA | CANCER | Piperazines - administration & dosage | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Induction Chemotherapy | Male | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | Antineoplastic Agents - administration & dosage | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Vincristine - administration & dosage | Female | Child | Disease Models, Animal | Dexamethasone - administration & dosage | Nitrophenols - administration & dosage | Mice, SCID | Asparaginase - administration & dosage | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biphenyl Compounds - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Mice | Sulfonamides - administration & dosage | Computers | Medical research | Services | Corticosteroids | Analysis | Medicine, Experimental | Acute lymphocytic leukemia | Video tape recorders and recording | Drugs | Health sciences | Therapy | Pediatrics | Animal models | Arsenic | Bcl-2 protein | Glucocorticoids | Leukemia | Lung cancer | Families & family life | Clinical trials | Cytotoxicity | Cancer therapies | Optimization | Immunosuppressive agents | Antagonism | Bcl-x protein | Xenografts | Bone marrow | Children | Drug dosages | Pharmaceutical sciences | Dexamethasone | Acute lymphatic leukemia | L-asparaginase | Arsenic trioxide | Pharmacology | FDA approval | Lymphatic leukemia | Tumor cell lines | Medical screening | Patients | Vincristine | Children & youth | Chemotherapy | Anthracycline | Biopsy | Medical prognosis | Stem cells | Fatalities | In vivo methods and tests | Asparaginase | Apoptosis
Journal Article
Journal Article
Journal Article
Journal Article
Xenobiotica, ISSN 0049-8254, 5/2009, Volume 39, Issue 5, pp. 407 - 414
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 2/2012, Volume 39, Issue 1, pp. 99 - 108
The purpose of this study was to investigate the effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide in rats... 
Biochemistry, general | Pharmacodynamics | Rat | Veterinary Medicine | CYP3A4 | Biomedical Engineering | P -gp | Biomedicine | Pharmacy | Repaglinide | Pharmacology/Toxicology | Pharmacokinetics | Efonidipine | P-gp | CYTOCHROMES P450 | DIHYDROPYRIDINE | PLASMA-CONCENTRATIONS | PHARMACOLOGY & PHARMACY | HYPERTENSION | EXPRESSION | HUMAN-LIVER | DRUG-METABOLISM | GLIBENCLAMIDE | CYCLOSPORINE | Antihypertensive Agents - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Area Under Curve | Humans | Cytochrome P-450 Enzyme System - metabolism | Biological Availability | Male | Carbamates - administration & dosage | Carbamates - pharmacokinetics | Ketoconazole - pharmacology | Hypoglycemic Agents - administration & dosage | Nitrophenols - pharmacology | Piperidines - pharmacology | Biocatalysis - drug effects | Organophosphorus Compounds - pharmacology | Piperidines - pharmacokinetics | Carbamates - pharmacology | Hypoglycemic Agents - pharmacokinetics | Piperidines - administration & dosage | Rats | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Pharmacological Phenomena - drug effects | Blood Glucose - drug effects | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Rhodamine 123 - metabolism | Animals | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Drug Interactions - physiology | Cell Line, Tumor | Dihydropyridines - pharmacology | Blood sugar | Analysis | Cytochrome P-450
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 09/2004, Volume 44, Issue 3, pp. 386 - 392
Calcium overload plays a key role in the development of atrial electrical remodeling. The effect of an L-type Ca channel blocker in preventing this remodeling... 
Electrophysiology | Atrium | Ca channel blocker | Arrhythmia (mechanism) | T-type Ca channel | FIBRILLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | DOG-MODEL | VULNERABILITY | FAILURE | REFRACTORY PERIOD | EFONIDIPINE | electrophysiology | arrhythmia (mechanism) | PHARMACOLOGY & PHARMACY | MIBEFRADIL | atrium | ANTIARRHYTHMIC-DRUGS | VERAPAMIL | Refractory Period, Electrophysiological - physiology | Heart Atria - drug effects | Calcium - metabolism | Dihydropyridines - administration & dosage | Calcium Channel Blockers - therapeutic use | Calcium Channels, L-Type - therapeutic use | Male | Atrial Fibrillation - physiopathology | Verapamil - administration & dosage | Nitrophenols - chemistry | Atrioventricular Node - drug effects | Calcium - antagonists & inhibitors | Time Factors | Dihydropyridines - pharmacokinetics | Nitrophenols - pharmacokinetics | Heart Atria - physiopathology | Refractory Period, Electrophysiological - drug effects | Atrioventricular Node - anatomy & histology | Dihydropyridines - chemistry | Administration, Oral | Japan | Calcium Channels, T-Type - therapeutic use | Verapamil - pharmacokinetics | Nitrophenols - administration & dosage | Organophosphorus Compounds - chemistry | Cardiac Pacing, Artificial - methods | Forecasting | Animals | Calcium Channels, T-Type - pharmacokinetics | Calcium Channels, L-Type - drug effects | Calcium Channels, T-Type - drug effects | Calcium Channel Blockers - administration & dosage | Dogs | Heart Atria - anatomy & histology | Organophosphorus Compounds - administration & dosage | Calcium Channel Blockers - pharmacokinetics | Organophosphorus Compounds - pharmacokinetics | Research Design | Atrial Fibrillation - prevention & control | Atrioventricular Node - physiopathology | Calcium Channels, L-Type - pharmacokinetics
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2007, Volume 35, Issue 7, pp. 1203 - 1208
Our previous studies described a newly identified potential of grapefruit juice (GFJ) in mediating pharmacokinetic drug interactions due to its capability of esterase inhibition... 
FELODIPINE INTERACTION | INACTIVATION | CYP3A | MECHANISM | NIFEDIPINE | PHARMACOLOGY & PHARMACY | IDENTIFICATION | 6',7'-DIHYDROXYBERGAMOTTIN | FURANOCOUMARINS | NARINGIN | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Nitrophenols - metabolism | Citrus paradisi | Intestinal Absorption - drug effects | Male | Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics | Angiotensin-Converting Enzyme Inhibitors - blood | Dose-Response Relationship, Drug | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Microsomes, Liver - drug effects | Flavonoids - pharmacology | Lovastatin - administration & dosage | Microsomes, Liver - enzymology | Enalapril - administration & dosage | Beverages - analysis | Caco-2 Cells | Enalapril - pharmacokinetics | Fruit | Administration, Oral | Lovastatin - pharmacokinetics | Flavanones - pharmacology | Food-Drug Interactions | Enzyme Inhibitors - pharmacology | Esterases - metabolism | Rats | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Rats, Sprague-Dawley | Enzyme Inhibitors - isolation & purification | Hydrolysis | Animals | Esterases - antagonists & inhibitors | Flavonoids - isolation & purification | Kaempferols - pharmacology | In Vitro Techniques
Journal Article
Journal Article
Archives of Toxicology, ISSN 0340-5761, 2000, Volume 74, Issue 7, pp. 388 - 396
Journal Article