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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2010, Volume 120, Issue 1, pp. 142 - 156
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2016, Volume 108, Issue 10, p. djw122
Journal Article
European Journal of Haematology, ISSN 0902-4441, 06/2012, Volume 88, Issue 6, pp. 535 - 548
Objectives:  Iron‐overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron... 
calcium channel | iron overload | cardiac iron | left ventricular function | heart rate variability | Iron overload | Cardiac iron | Calcium channel | Heart rate variability | Left ventricular function | MALONDIALDEHYDE | QUANTIFICATION | CA2+ CHANNELS | CARDIAC MYOCYTES | RATS | CARDIOMYOCYTES | TRANSFERRIN-BOUND IRON | HEART-RATE-VARIABILITY | IRON-OVERLOAD CARDIOMYOPATHY | HEMATOLOGY | EXPRESSION | beta-Thalassemia - pathology | Humans | Calcium Channel Blockers - therapeutic use | beta-Thalassemia - genetics | Deferoxamine - therapeutic use | Azoles - therapeutic use | DNA Primers - genetics | Iron, Dietary - administration & dosage | RNA, Messenger - metabolism | Cardiovascular System - physiopathology | Verapamil - therapeutic use | Base Sequence | Nifedipine - therapeutic use | Nitrophenols - therapeutic use | Calcium Channels, T-Type - genetics | Organoselenium Compounds - therapeutic use | Disease Models, Animal | Iron - blood | Heart Rate | Iron Chelating Agents - therapeutic use | Mice, Inbred C57BL | RNA, Messenger - genetics | Ventricular Function, Left - drug effects | Organophosphorus Compounds - therapeutic use | beta-Thalassemia - physiopathology | Cardiovascular System - drug effects | Iron - metabolism | Mice, Knockout | Dihydropyridines - therapeutic use | beta-Thalassemia - drug therapy | Organ Size - drug effects | Animals | Calcium Channels, L-Type - genetics | Calcium Channels, L-Type - drug effects | Calcium Channels, T-Type - drug effects | Mice | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 2, pp. 418 - 430
Background Asthmatic inflammation is dominated by accumulation of either eosinophils, neutrophils, or both in the airways. Disposal of these inflammatory cells... 
Allergy and Immunology | Bcl-2 | apoptosis | steroid insensitive | Airway inflammation | eosinophil | neutrophil | SURVIVAL | MANAGEMENT | SPUTUM | IMMUNOLOGY | CELL-DEATH | FAMILY | ALLERGY | ASTHMA | GLUCOCORTICOID RESISTANCE | MOLECULAR-MECHANISMS | Asthma - metabolism | Eosinophils - drug effects | Ovalbumin - immunology | Apoptosis - drug effects | Humans | Male | Adrenal Cortex Hormones - therapeutic use | Biphenyl Compounds - therapeutic use | Eosinophils - immunology | Freund's Adjuvant - immunology | Alum Compounds | Proto-Oncogene Proteins c-bcl-2 - metabolism | Dexamethasone - pharmacology | Allergens - immunology | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Nitrophenols - therapeutic use | Asthma - immunology | Anti-Inflammatory Agents - therapeutic use | Bronchoalveolar Lavage Fluid - cytology | Lung - metabolism | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - immunology | Adrenal Cortex Hormones - pharmacology | Mice, Transgenic | Drug Resistance - drug effects | Piperazines - therapeutic use | Sulfonamides - pharmacology | Asthma - drug therapy | Piperazines - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Dexamethasone - therapeutic use | Animals | Sulfonamides - therapeutic use | Lung - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Yuan (China) | Medical research | Medical colleges | Corticosteroids | Medicine, Experimental | Inflammation | Health aspects | Asthma | Dendritic cells | Analysis | Health care | Drugs | Corticoids | Allergens | Animal models | Bcl-2 protein | Immune clearance | Helper cells | Lymphocytes T | Inflammatory diseases | Immunosuppressive agents | Respiratory tract | Transgenic animals | Bronchoalveolar lavage | Rodents | Respiratory tract diseases | Alveoli | Public health | Leukocytes (eosinophilic) | Neutrophils | Transgenic mice | Bronchus | Leukocytes (neutrophilic) | FDA approval | Disease control | Allergies | Hemopoiesis | Immune systems | Studies | Inhibitors | Mice | Leukocytes (granulocytic) | Steroid hormones | Steroids | Apoptosis | Eosinophils | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2766 - 2771
Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease.... 
Chemotherapy | Estrogens | Antineoplastics | BREAST CANCER SPECIAL FEATURE | Breast cancer | Breast neoplasms | Heterologous transplantation | Tumors | Cancer | Vehicles | Apoptosis | Programmed cell death | ABT-263 | Mammary | Navitoclax | Small molecule inhibitor | CANCER CELLS | SUBTYPES | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | CYTOTOXIC CHEMOTHERAPY | navitoclax | mammary | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PROGNOSTIC MARKER | programmed cell death | INHIBITOR | PROTEINS | BCL-2 FAMILY | small molecule inhibitor | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Biphenyl Compounds - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Taxoids - therapeutic use | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Nitrophenols - therapeutic use | Female | Membrane Proteins - metabolism | Breast Neoplasms - classification | Proto-Oncogene Proteins - metabolism | Piperazines - therapeutic use | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Remission Induction | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Mice | bcl-X Protein - metabolism | Breast tumors | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Tumor proteins | Health aspects | Survival analysis | Breasts | Index Medicus | Biological Sciences
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 389 - 399
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might... 
CELLCYCLE | SURVIVAL | SELICICLIB CYC202 | R-ROSCOVITINE | ONCOLOGY | SMALL-MOLECULE INHIBITORS | DOWN-REGULATION | DEATH | KINASE INHIBITOR | FAMILY PROTEINS | MULTIPLE-MYELOMA CELLS | BH3-ONLY PROTEINS | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Male | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Nitrophenols - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Fibroblasts - metabolism | Protein Structure, Tertiary | Cytokines - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mice, Transgenic | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Proteins | Lymphomas | Analysis | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1081 - 1097
Signaling via the MyD88/IRAK pathway in T cells is indispensable for cell survival; however, it is not known whether this pathway functions in the progression... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | SIGNALING PATHWAY | INDUCED APOPTOSIS | TOLL-LIKE RECEPTOR | KINASE | INNATE IMMUNE-SYSTEM | INTERLEUKIN-1 RECEPTOR | ANTITUMOR-ACTIVITY | EXPRESSION | MYD88 | Vincristine - pharmacology | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Antineoplastic Agents - therapeutic use | Biphenyl Compounds - therapeutic use | Biphenyl Compounds - pharmacology | MCF-7 Cells | Nitrophenols - pharmacology | Nitrophenols - therapeutic use | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Protein Stability | Benzimidazoles - therapeutic use | Cell Survival - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Jurkat Cells | Mice, Inbred C57BL | Piperazines - therapeutic use | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | Vincristine - therapeutic use | Benzimidazoles - pharmacology | Mice, Inbred NOD | Cell Proliferation - drug effects | Antimitotic agents | Medical research | Chemotherapy | Physiological aspects | Medicine, Experimental | Research | Acute lymphocytic leukemia | Antineoplastic agents | T cells | Cancer | Flow cytometry | Phosphorylation | Leukemia | Values | Kinases | Experiments | Cancer therapies | Patients | Studies | Lymphocytes | Rodents | Medical prognosis | Adapter proteins | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
BLOOD, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5807 - 5816
The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising antitumor efficacy in preclinical and... 
MULTIPLE-MYELOMA | LUNG-CANCER | ANTAGONIST ABT-737 | FAMILY-MEMBERS | ACUTE LYMPHOBLASTIC-LEUKEMIA | APOPTOTIC RESPONSES | CHRONIC LYMPHOCYTIC-LEUKEMIA | BH3 MIMETIC ABT-737 | HEMATOLOGY | EXPRESSION | INHIBITOR ABT-737 | Leukemia - pathology | Humans | Molecular Targeted Therapy | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lymphoma - drug therapy | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | bcl-X Protein - antagonists & inhibitors | Nitrophenols - therapeutic use | Protein Binding - drug effects | Cytoprotection - drug effects | Lymphoma - pathology | Membrane Proteins - metabolism | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Leukemia - genetics | Proto-Oncogene Proteins - metabolism | Aniline Compounds - pharmacology | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Leukemia - drug therapy | Lymphoma - genetics | Mutant Proteins - metabolism | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - therapeutic use | bcl-X Protein - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus | Abridged Index Medicus
Journal Article