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Clinical and Experimental Pharmacology and Physiology, ISSN 1440-1681, 02/2008, Volume 35, Issue 2, pp. 192 - 200
SUMMARY • The present study evaluated the effect of diabetes, hypercholesterolaemia and their combination on the contribution of nitric oxide (NO) and... 
endothelium-derived hyperpolarising factor | diabetes | endothelium-dependent relaxation | hypercholesterolaemia | superoxide anion | endothelium‐derived hyperpolarising factor | endothelium‐dependent relaxation | Superoxide anion | Diabetes | Hypercholesterolaemia | Endothelium-dependent relaxation | Endothelium-derived hyperpolarising factor | PHYSIOLOGY | NITRO-L-ARGININE | ACETYLCHOLINE | MELLITUS | NAD(P)H OXIDASE | ARTERIES | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | CHANNELS | DYSFUNCTION | EDHF | Body Weight | Oxidative Stress | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Superoxides - metabolism | Aorta, Thoracic - drug effects | Biological Factors - metabolism | Diabetes Mellitus, Experimental - metabolism | Potassium Channel Blockers - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Diabetes Mellitus, Type 1 - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - enzymology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Hypercholesterolemia - physiopathology | Nitric Oxide Synthase - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Charybdotoxin, pharmacology | Diabetes Mellitus, Type 1, physiopathology | Nitric Oxide Synthase, antagonists and inhibitors | Aorta, Thoracic, physiopathology | Potassium Channels, Calcium-Activated, antagonists and inhibitors | Hypercholesterolemia, metabolism | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | Aorta, Thoracic, drug effects | Aorta, Thoracic, metabolism | Receptors, Cytoplasmic and Nuclear, antagonists and inhibitors | Vasodilator Agents, pharmacology | Vasodilation | Nitric Oxide Synthase, metabolism | Cyclooxygenase Inhibitors, pharmacology | Apamin, pharmacology | Nitroarginine, pharmacology | Potassium Channel Blockers, pharmacology | Vasodilation, drug effects | Cholesterol, blood | Receptors, Cytoplasmic and Nuclear, metabolism | Biological Factors, metabolism | Diabetes Mellitus, Experimental, physiopathology | Nitric Oxide, metabolism | Acetylcholine, pharmacology | Diabetes Mellitus, Experimental, metabolism | Nitroprusside, pharmacology | Oxadiazoles, pharmacology | Blood Glucose, metabolism | Potassium Channels, Calcium-Activated, metabolism | Aorta, Thoracic, enzymology | Hypercholesterolemia, physiopathology | Diabetes Mellitus, Type 1, metabolism | Guanylate Cyclase, antagonists and inhibitors | Guanylate Cyclase, metabolism | Superoxides, metabolism | Indomethacin, pharmacology | Superoxide | Hypercholesterolemia | Endothelium-derived relaxing factors | Type 1 diabetes | Endothelium
Journal Article
British journal of pharmacology, ISSN 1476-5381, 2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
eNOS | PAF | PI3K | VEGF | PLC | PLA2 | PKC | PLA | PROTEIN-KINASE-C | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | VASCULAR-PERMEABILITY | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | NEOVASCULARIZATION | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Papers
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2009, Volume 296, Issue 2, pp. 470 - 479
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial... 
Green fluorescent protein- Microtubule-associated protein light chain 3 | Lipopolysaccharide | Oxidative stress | Hl-1 cardiac myocyte | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HL-1 cardiac myocyte | CARDIAC MYOCYTES | ENDOTOXIN | MYOCARDIAL DEPRESSION | CELL-DEATH | IN-VITRO | SCAVENGER RECEPTOR | green fluorescent protein-microtubule-associated protein light chain 3 | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | lipopolysaccharide | EXPRESSION | oxidative stress | Tumor Necrosis Factor-alpha - metabolism | Mitochondria, Heart - metabolism | Glutathione - metabolism | Mitochondria, Heart - pathology | Nitric Oxide Synthase - antagonists & inhibitors | omega-N-Methylarginine - pharmacology | Mitochondria, Heart - drug effects | Nitroprusside - pharmacology | Autophagy - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Donors - pharmacology | Cytoprotection | Animals, Newborn | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Sirolimus - pharmacology | Hydrogen Peroxide - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | Lipopolysaccharides - pharmacology | Myocytes, Cardiac - metabolism | Mice | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 2005, Volume 96, Issue 1, pp. 119 - 126
Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues. A large part of the... 
Vascular remodeling | Tissue transglutaminase | Vasoconstriction | Blood flow | INDUCED ACTIVATION | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | CROSS-LINKING | SPASM | tissue transglutaminase | vascular remodeling | FLOW | STRUCTURAL-CHANGES | ADAPTATION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | HYPERTENSION | HEMATOLOGY | blood flow | Norepinephrine - pharmacology | GTP-Binding Proteins - pharmacology | Mesenteric Arteries - physiology | Cross-Linking Reagents - pharmacology | Endothelin-1 - pharmacology | Transglutaminases - pharmacology | Transglutaminases - genetics | Nitroprusside - pharmacology | Hemorheology | Cadaverine - pharmacology | GTP-Binding Proteins - genetics | Vasoconstriction - physiology | Enzyme Induction - drug effects | Cystamine - pharmacology | Female | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - cytology | Organ Culture Techniques | Muscle, Skeletal - blood supply | Tretinoin - pharmacology | Vasoconstrictor Agents - pharmacology | Extracellular Matrix Proteins - chemistry | GTP-Binding Proteins - physiology | Guinea Pigs | Vasodilator Agents - pharmacology | Gels | Cell Size - drug effects | Transglutaminases - biosynthesis | Rats | Nitric Oxide - physiology | Papaverine - pharmacology | Arteries - drug effects | Vasoconstriction - drug effects | Extracellular Matrix Proteins - drug effects | Extracellular Matrix - ultrastructure | Animals | Arteries - enzymology | Coronary Vessels - cytology | Vasomotor System - physiology | Collagen | Biotin - pharmacology | Transglutaminases - physiology | GTP-Binding Proteins - biosynthesis | Amines - pharmacology | Mesenteric Arteries - enzymology | Sus scrofa | Biotin - analogs & derivatives
Journal Article
Journal of sexual medicine, ISSN 1743-6095, 12/2012, Volume 9, Issue 12, pp. 3028 - 3040
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 04/2006, Volume 33, Issue 4, pp. 345 - 350
SUMMARY • There is a growing interest in the anti-oxidant characteristics and use of flavonoids in the management of cardiovascular diseases. The... 
endothelium | ascorbic acid | nitric oxide | anti-oxidants | quercetin | SHR | hypertension | anti‐oxidants | Anti-oxidants | Hypertension | Ascorbic acid | Nitric oxide | Quercetin | Endothelium | PHYSIOLOGY | MECHANISM | NITRIC-OXIDE SYNTHASE | FLAVONOIDS | ENDOTHELIUM-DEPENDENT VASODILATION | TEA | SUPEROXIDE ANION | PATHWAY | PHARMACOLOGY & PHARMACY | RED WINE | NG-Nitroarginine Methyl Ester - pharmacology | Rats, Inbred SHR | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Aorta - drug effects | Enzyme Inhibitors - pharmacology | Adrenergic alpha-1 Receptor Agonists | Rats | Rats, Inbred WKY | Male | Nitroprusside - pharmacology | Vitamins - pharmacology | Endothelium, Vascular - physiology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Animals | Phenylephrine - pharmacology | Quercetin - pharmacology | Muscle Contraction - drug effects | Ascorbic Acid - pharmacology | Adrenergic alpha-Agonists - pharmacology | Muscle Relaxation - drug effects | In Vitro Techniques | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester, pharmacology | Ascorbic Acid, pharmacology | Comparative Study | Adrenergic alpha-Agonists, pharmacology | Receptors, Adrenergic, alpha-1, agonists | Aorta, drug effects | Acetylcholine, pharmacology | Enzyme Inhibitors, pharmacology | In Vitro | Muscle Contraction, drug effects | Nitroprusside, pharmacology | Vasodilator Agents, pharmacology | Vitamins, pharmacology | Quercetin, pharmacology | Nitric Oxide Synthase Type III, antagonists and inhibitors | Phenylephrine, pharmacology | Endothelium, Vascular, physiology | Muscle, Smooth, Vascular, drug effects | Muscle Relaxation, drug effects | Vitamin C
Journal Article
Journal of sexual medicine, ISSN 1743-6095, 04/2013, Volume 10, Issue 4, pp. 960 - 971
Prevalence of erectile dysfunction (ED) increases progressively with aging, but the ED pathophysiology at its early stages is still poorly investigated. This... 
Erectile Dysfunction | Antioxidant Therapy | Oxidative Stress | Corpus Cavernosum | Apocynin | Superoxide Dismutase | STIMULATOR BAY 41-2272 | HUMAN CORPUS CAVERNOSUM | RELAXATION | DIABETIC-RATS | PHOSPHODIESTERASE TYPE-5 INHIBITORS | SOLUBLE GUANYLATE-CYCLASE | SMOOTH-MUSCLE | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | ENDOGENOUS NITRIC-OXIDE | Blood Pressure | Free Radical Scavengers - pharmacology | Cyclic GMP - pharmacology | Up-Regulation | Electric Stimulation | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Penile Erection | Sildenafil Citrate | Cyclic GMP - analogs & derivatives | Acetophenones - pharmacology | NADPH Oxidases - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Superoxide Dismutase - metabolism | Pyrazoles - pharmacology | Superoxide Dismutase - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Purines - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Rats | Muscle Relaxation | NADPH Oxidase 2 | Piperazines - pharmacology | Erectile Dysfunction - metabolism | Membrane Glycoproteins - genetics | Animals | Aging - physiology | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Superoxide Dismutase-1 | Prevention | Oxidases | Antioxidants | Impotence | Nitric oxide | Sodium nitroferricyanide | Superoxide
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 10/2005, Volume 32, Issue 10, pp. 817 - 824
SUMMARY 1. Rho-kinase (ROK) stimulation represents a key step in the maintenance of agonist-induced contraction, an effect counteracted by nitric oxide (NO)... 
Rho-kinase | nitric oxide | coeliac artery | Rho guanine nucleotide exchange factors | RhoA | Rho‐kinase | Coeliac artery | Nitric oxide | RHO-ASSOCIATED KINASE | PHYSIOLOGY | P115 RHOGEF | VASCULAR SMOOTH-MUSCLE | NUCLEOTIDE EXCHANGE FACTORS | SIGNAL-TRANSDUCTION | CONTRACTION | RENIN-ANGIOTENSIN SYSTEM | GTPASE-ACTIVATING PROTEINS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | MYOSIN LIGHT-CHAIN | Celiac Artery - physiology | Gene Expression - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Male | rhoA GTP-Binding Protein - metabolism | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Oxadiazoles - pharmacology | rho-Associated Kinases | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Guanine Nucleotide Exchange Factors - genetics | Vasodilator Agents - pharmacology | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Rats | Rho Guanine Nucleotide Exchange Factors | Potassium - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Celiac Artery - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Cyclic GMP - metabolism | Signal Transduction - physiology | Pyridines - pharmacology | Vasodilation - drug effects | In Vitro Techniques | Celiac Artery - metabolism | NG-Nitroarginine Methyl Ester, pharmacology | Nitric Oxide Synthase, antagonists and inhibitors | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | In Vitro | Vasodilator Agents, pharmacology | Cyclooxygenase Inhibitors, pharmacology | Pyridines, pharmacology | Guanine Nucleotide Exchange Factors, genetics | Vasoconstrictor Agents, pharmacology | RNA, Messenger, genetics | Celiac Artery, drug effects | Potassium, pharmacology | Protein-Serine-Threonine Kinases, metabolism | Amides, pharmacology | Vasodilation, drug effects | Gene Expression, drug effects | Nitroprusside, pharmacology | rhoA GTP-Binding Protein, metabolism | Oxadiazoles, pharmacology | Phenylephrine, pharmacology | Guanylate Cyclase, antagonists and inhibitors | Signal Transduction, physiology | Cyclic GMP, metabolism | Indomethacin, pharmacology
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 1/2013, Volume 81, Issue 1, pp. 27 - 40
Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme... 
Life Sciences | Biochemistry, general | Plant Pathology | α - Amy2/54 gene expression | Nitric oxide | Heme oxygenase-1 | cGMP | Aleurone layers | Plant Sciences | Triticum aestivum | α-Amy2/54 gene expression | ARABIDOPSIS-THALIANA | SEED-GERMINATION | ADVENTITIOUS ROOTING PROCESS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GUANYLYL CYCLASE ACTIVITY | GIBBERELLIN-RESPONSE MUTANT | BARLEY ALEURONE | PLANT SCIENCES | PROGRAMMED CELL-DEATH | INHIBITS APOPTOSIS | alpha-Amy2/54 gene expression | ABSCISIC-ACID | Cyclic GMP - pharmacology | Heme Oxygenase-1 - metabolism | Gene Expression - drug effects | Nitric Oxide - pharmacology | Protoporphyrins - pharmacology | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | alpha-Amylases - genetics | Heme Oxygenase-1 - genetics | Carbon Monoxide - pharmacology | Cyclic GMP - analogs & derivatives | Plant Proteins - antagonists & inhibitors | Plant Proteins - metabolism | Nitric Oxide Donors - pharmacology | Triticum - enzymology | Aminoquinolines - pharmacology | Genes, Plant - drug effects | Spermine - analogs & derivatives | Signal Transduction | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | alpha-Amylases - metabolism | Heme Oxygenase-1 - antagonists & inhibitors | Triticum - genetics | Plant Proteins - genetics | Spermine - pharmacology | Benzoates - pharmacology | Gibberellins - pharmacology | Nitric Oxide - metabolism | Plant Growth Regulators - pharmacology | Triticum - drug effects
Journal Article
Scientific reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, p. 6963
Journal Article