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PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e25519
Background: Ankrd2 (also known as Arpp) together with Ankrd1/CARP and DARP are members of the MARP mechanosensing proteins that form a complex with titin... 
SKELETAL-MUSCLE | CARP | PDZ DOMAINS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ANKYRIN-REPEAT PROTEIN | NUCLEAR-PROTEIN | TIGHT JUNCTION | CELL | BINDING | FAMILY | Homeodomain Proteins - metabolism | Humans | Transcriptome | Muscle Proteins - deficiency | Muscle Fibers, Skeletal - metabolism | Promoter Regions, Genetic - genetics | RNA Interference | Repressor Proteins - deficiency | Nuclear Proteins - deficiency | Muscle Proteins - metabolism | Transcription, Genetic | Nuclear Proteins - genetics | Muscle, Striated - cytology | Repressor Proteins - metabolism | Cell Line | Tumor Suppressor Protein p53 - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | MyoD Protein - metabolism | src Homology Domains | Muscle Proteins - genetics | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Mechanotransduction, Cellular | Animals | PDZ Domains | Muscle Fibers, Skeletal - cytology | Muscle, Striated - metabolism | Actin | Genes | Calpain | Bone morphogenetic proteins | Cellular signal transduction | DNA binding proteins | Genetic transcription | Transforming growth factors | Tumor proteins | Muscle proteins | Protein binding | Heart | Biotechnology | Transcription factors | Intercellular signalling | Connectin | Wnt protein | Calcium | Cardiomyopathy | p53 Protein | Homeostasis | Intracellular signalling | Feedback loops | Nuclei | Proteins | Signal transduction | Endocytosis | Pathways | Methyl-CpG binding protein | Rodents | DNA methylation | Localization | Nkx2.5 protein | Deoxyribonucleic acid--DNA | MyoD protein | Myotubes | Calcium (intracellular) | Carp | MAP kinase | Cardiomyocytes | Gene expression | Insulin | Skeletal muscle | Myoblasts | Pax6 protein | Musculoskeletal system | MeCP2 protein | Cytoskeleton | Genetic engineering | Mutation | Molecular biology | Cytoplasm | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e15151
Background: Development of molecules chemically modifying the expression of crucial orchestrator(s) of stem cell commitment may have significant biomedical... 
MIXED ESTERS | HEART | IN-VITRO | TGF-BETA | MESODERM | HIGH-THROUGHPUT | TRANSCRIPTION | BIOLOGY | DIFFERENTIATION | NKX2-5 | DROSOPHILA | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Esters | Hyaluronic Acid - pharmacology | Smad3 Protein - metabolism | Smad3 Protein - genetics | Mesenchymal Stromal Cells - cytology | RNA Interference | Smad4 Protein - genetics | HEK293 Cells | Smad1 Protein - genetics | Butyric Acid - pharmacology | Smad7 Protein - genetics | Smad7 Protein - metabolism | Tretinoin - pharmacology | Myocytes, Cardiac - cytology | Cells, Cultured | Hyaluronic Acid - chemistry | Mesenchymal Stromal Cells - metabolism | Smad Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Smad4 Protein - metabolism | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Myocytes, Cardiac - metabolism | Smad1 Protein - metabolism | Mice | Smad Proteins - metabolism | Analysis | Genes | Stem cells | Genetic research | Transplantation | Genetic transcription | Precipitation (Meteorology) | Hyaluronic acid | Saturated fatty acids | Heart | Pattern formation | Actinin | Embryo cells | Nuclei | Smad4 protein | Proteins | Hyaluronan | Growth factors | Nkx2.5 protein | Medical research | Fetuses | Conductors | Gene expression | Embryos | Studies | Polymerase chain reaction | Placenta | Insects | Runoff | Biotechnology | Chromatin | Membranes | Smad protein | Transcription | Mesenchyme | Laboratories | Fluorescence | Stem cell transplantation | Kinases | Engineering | Embryogenesis | Allografts | Cell fate | Transgenic animals | Rodents | Mathematical models | Gene transfer | Cardiomyocytes | Medicine | Signaling | Acids | Smad7 protein | Molecular biology | Immunofluorescence | Combinatorial analysis | Cancer
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 03/2015, Volume 569, pp. 45 - 53
Transcription factor Nkx2.5, essential for heart development, regulates cardiomyocyte-specific gene expression through combinatorial interactions with other... 
Heart | Ankrd2 | Nkx2.5 | Stress response | p53 | Apoptosis | ANKYRIN REPEAT PROTEIN | DOXORUBICIN-INDUCED APOPTOSIS | FACTOR CSX/NKX2-5 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-BINDING TARGETS | MUSCLE DIFFERENTIATION | BIOPHYSICS | CONGENITAL HEART-DISEASE | IN-VIVO | GENE-EXPRESSION | UP-REGULATION | TRANSGENIC MICE | Proto-Oncogene Proteins c-mdm2 - genetics | Cell Proliferation | Transcription Factors - chemistry | Homeodomain Proteins - metabolism | Humans | Transcriptional Activation | Cercopithecus aethiops | Recombinant Fusion Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Protein Interaction Maps | Heart Defects, Congenital - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Myocardium - metabolism | Muscle Proteins - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | bcl-2-Associated X Protein - genetics | Cell Line | Promoter Regions, Genetic | Repressor Proteins - chemistry | Muscle Development - physiology | Gene Expression Regulation | Mutant Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Repressor Proteins - genetics | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Homeodomain Proteins - chemistry | Nuclear Proteins - chemistry | Homeodomain Proteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Animals | Mutant Proteins - chemistry | Muscle Development - genetics | Recombinant Fusion Proteins - genetics | Heart Defects, Congenital - metabolism | Mice | Muscle Proteins - chemistry | Tumor Suppressor Protein p53 - chemistry | COS Cells | Tumor proteins | Cardiac patients
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2009, Volume 4, Issue 3, p. e4882
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24812
Reversible post-translational protein modifications such as SUMOylation add complexity to cardiac transcriptional regulation. The homeodomain transcription... 
CONJUGATION | CONDUCTION SYSTEM | PROTEIN | MULTIDISCIPLINARY SCIENCES | CONGENITAL HEART-DISEASE | SERUM RESPONSE FACTOR | GENE-EXPRESSION | CSX/NKX2.5 HOMEOPROTEIN | INTERACTING MOTIF | CHAMBER FORMATION | SUMOYLATION | Immunohistochemistry | Cell Line | Immunoprecipitation | Small Ubiquitin-Related Modifier Proteins - metabolism | Homeodomain Proteins - metabolism | Humans | Cercopithecus aethiops | Protein Inhibitors of Activated STAT - metabolism | Ubiquitin-Activating Enzymes - metabolism | Blotting, Western | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Animals | SUMO-1 Protein - genetics | Myocardium - metabolism | Fluorescent Antibody Technique | Electrophoretic Mobility Shift Assay | Mice | SUMO-1 Protein - metabolism | COS Cells | Gene mutations | Lysine | Sumo | Heart | Transcription factors | Gene regulation | Smooth muscle | Genomes | Biology | Synergism | Cofactors | Defects | Complexity | Homeobox | Proteins | Morphogenesis | SUMO protein | Signal transduction | Arginine | Transgenic animals | Rodents | Transcription activation | DNA methylation | Post-translation | Localization | Heart diseases | Nkx2.5 protein | Deoxyribonucleic acid--DNA | Binding | Heart failure | Gene expression | Medicine | Cell lines | Point mutation | Regulatory mechanisms (biology) | Stem cells | Photoreceptors | Mutation | Deoxyribonucleic acid | DNA
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2018, Volume 233, Issue 3, pp. 1812 - 1822
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95253
Transcription factors play a crucial role in regulation of cardiac biology. FOG-2 is indispensable in this setting, predominantly functioning through a... 
WNT SIGNALING PATHWAY | UXT | CELLS | HYPERTROPHY | COACTIVATOR | MULTIDISCIPLINARY SCIENCES | HEART MORPHOGENESIS | UNFOLDED PROTEINS | CARDIOMYOCYTE DIFFERENTIATION | TBX5 | UBIQUITOUSLY EXPRESSED TRANSCRIPT | Cell Line | GATA4 Transcription Factor - metabolism | Myocytes, Cardiac - cytology | Ventricular Myosins - biosynthesis | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation - physiology | Repressor Proteins - genetics | GATA4 Transcription Factor - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Neoplasm Proteins - metabolism | Homeodomain Proteins - genetics | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Myocytes, Cardiac - metabolism | Adult | Neoplasm Proteins - genetics | Repressor Proteins - metabolism | Ventricular Myosins - genetics | Physiological aspects | Transcription factors | Genetic aspects | Research | Heart cells | Heart | Regulators | Yeast | Disease | Genes | Gene regulation | Amino acids | Atrial natriuretic peptide | Biology | Kinases | Proteins | Myosin | Cell cycle | Heart diseases | Nkx2.5 protein | Fog | Brain natriuretic peptide | Medical research | Antigens | Congenital diseases | Cloning | Cardiomyocytes | Gene expression | Medical screening | Medicine | FOG-2 protein | DNA microarrays | Mutation
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2017, Volume 35, Issue 2, pp. 351 - 361
Vascular smooth muscle cells (VSMCs) derived from cardiovascular progenitor cell (CVPC) lineage populate the tunica media of the aortic root. Understanding... 
Yes‐associated protein | Vascular smooth muscle cell | Cardiovascular progenitor cell | Differentiation | Stem cells | Yes-associated protein | TISSUE | YAP | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SWITCH | HEMATOLOGY | EXPRESSION | Biomarkers - metabolism | Cell Line | Promoter Regions, Genetic | Myocytes, Cardiac - cytology | Humans | Homeobox Protein Nkx-2.5 - metabolism | Nuclear Proteins - metabolism | Stem Cells - cytology | Muscle, Smooth, Vascular - cytology | Phosphoproteins - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Cell Lineage | Models, Biological | Trans-Activators - genetics | Protein Binding | Trans-Activators - metabolism | Transcription, Genetic | Adaptor Proteins, Signal Transducing - metabolism | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - cytology | Proteins | Promoters (Genetics) | Aneurysms | Smooth muscle | Genetic transcription | Cell differentiation | Embryonic stem cells | Health aspects | Protein binding | Rodents | PAC1 protein | Transcription | Embryo cells | Contractility | Cell lineage | Pharmacology | In vitro testing | Chemical compounds | Muscle contraction | Molecular modelling | Aorta | Inhibition | Nkx2.5 protein | stem cells | cardiovascular progenitor cell | differentiation | vascular smooth muscle cell
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 6, pp. 2235 - 2248
Congenital heart disease (CHD) represents the most prevalent inborn anomaly. Only a minority of CHD cases are attributed to genetic causes, suggesting a major... 
PROGENITOR CELLS | OXYGEN | MEDICINE, RESEARCH & EXPERIMENTAL | INDUCIBLE FACTORS | EMBRYONIC MOUSE HEART | MYOCARDIAL-CELLS | PATHWAY | TRANSCRIPTION | REMODELING COMPLEX NORC | MUSCLE | SIRT1 | Sirtuin 1 - metabolism | Cell Proliferation | LIM-Homeodomain Proteins - metabolism | Heart Defects, Congenital - etiology | Humans | Homeobox Protein Nkx-2.5 - metabolism | Sirtuin 1 - genetics | Cell Hypoxia | Gene Expression Regulation, Developmental | Myocardium - metabolism | HEK293 Cells | Female | Homeobox Protein Nkx-2.5 - genetics | Spatio-Temporal Analysis | Gene Expression | Embryo, Mammalian - pathology | Signal Transduction | Mice, Inbred C57BL | Gene Silencing | Heart Defects, Congenital - pathology | Histone Deacetylases - metabolism | Mice, Transgenic | Myocardium - pathology | Transcription Factors - genetics | Pregnancy | Transcription Factors - metabolism | LIM-Homeodomain Proteins - genetics | Animals | Heart Defects, Congenital - metabolism | Causes of | Cellular signal transduction | Congenital heart disease | Health aspects | Cell proliferation | Heart | Transcription factors | Spatial discrimination | Homeostasis | Cardiovascular disease | Homeobox | Morphogenesis | Proteins | Physiology | Pancreas | Heart diseases | Nkx2.5 protein | Congenital diseases | Cardiomyocytes | Environmental factors | Roles | RNA polymerase | Gene expression | SIRT1 protein | Coronary artery disease | Islet-1 protein | Stem cells | Hypoxia | Notch protein | Islets of Langerhans | Oxygenation
Journal Article
Journal Article