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Journal Article
Pain, ISSN 0304-3959, 2011, Volume 152, Issue 5, pp. 1165 - 1172
Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and... 
Blockade | Pain | Noxious cold | TRPA1 | Temperature regulation | Temperature sensation | ACTIVATION | TRPV1 | NEUROSCIENCES | SENSORY NEURONS | CLINICAL NEUROLOGY | THERMOREGULATION | INFLAMMATION | ION-CHANNEL | ANESTHESIOLOGY | HYPERALGESIA | TRPM8 | CONTRIBUTES | NOCICEPTION | Calcium Channels - metabolism | Body Temperature - drug effects | Calcium - metabolism | Humans | Male | Pain - metabolism | Drug Interactions | Pain - genetics | Transient Receptor Potential Channels - metabolism | Calcitonin Gene-Related Peptide - metabolism | Calcium Channels - genetics | Isothiocyanates - pharmacology | Disease Models, Animal | Body Temperature Regulation - physiology | Rats | Rats, Sprague-Dawley | Sensation - drug effects | Pain - physiopathology | Transient Receptor Potential Channels - genetics | Ganglia, Spinal - pathology | Mice | Body Temperature Regulation - genetics | Transient Receptor Potential Channels - antagonists & inhibitors | Sensation - physiology | Magnetic Resonance Imaging - methods | Oximes - therapeutic use | Tritium | Body Temperature - physiology | Heart Rate - drug effects | TRPV Cation Channels - metabolism | Pain - drug therapy | Reaction Time - drug effects | Heart Rate - physiology | Inhibitory Concentration 50 | Body Temperature Regulation - drug effects | Blood Pressure - drug effects | Blood Pressure - physiology | Neurons - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Cells, Cultured | Nerve Tissue Proteins - genetics | Cold Temperature - adverse effects | TRPV Cation Channels - genetics | Hyperalgesia - physiopathology | Nerve Tissue Proteins - metabolism | Pain Measurement - methods | Animals | Hyperalgesia - drug therapy | TRPA1 Cation Channel | Oximes - pharmacology | Sensory Thresholds - drug effects
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2017, Volume 82, Issue 7, pp. 472 - 487
Journal Article
Nature Communications, ISSN 2041-1723, 01/2014, Volume 5, Issue 1, p. 3125
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 668, Issue 3, pp. 497 - 506
We have previously shown that treating streptozotocin-induced diabetic rats, an animal model of type 1 diabetes, with Ilepatril (an inhibitor of neutral... 
Diabetic neuropathy | Diabetes | Neutral endopeptidase | Vasopeptidase inhibitor | Angiotensin converting enzyme | Vascular relaxation | IMPROVES INSULIN SENSITIVITY | ENDOTHELIAL DYSFUNCTION | VASOPEPTIDASE INHIBITOR OMAPATRILAT | INCREASED ENERGY-EXPENDITURE | ANGIOTENSIN-CONVERTING-ENZYME | NEUTRAL ENDOPEPTIDASE ACTIVITY | SKELETAL-MUSCLE | NERVE CONDUCTION-VELOCITY | GLUCOSE-TRANSPORT ACTIVITY | PHARMACOLOGY & PHARMACY | ENDONEURIAL BLOOD-FLOW | Blood Vessels - metabolism | Nervous System - metabolism | Thiobarbiturates - metabolism | Body Weight - drug effects | Male | Tyrosine - analogs & derivatives | Nervous System - pathology | Arterioles - physiopathology | Muscle, Skeletal - drug effects | Nociception - drug effects | Diabetes Mellitus, Experimental - complications | Nerve Fibers - pathology | Nerve Fibers - metabolism | Diabetes Complications - physiopathology | Diabetes Complications - metabolism | Enzyme Inhibitors - pharmacology | Lens, Crystalline - metabolism | Rats | Diabetes Complications - drug therapy | Arterioles - drug effects | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Tyrosine - metabolism | Heterocyclic Compounds, 3-Ring - therapeutic use | Vasodilation - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Adipose Tissue - drug effects | Carbohydrate Metabolism - drug effects | Glutathione - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Blood Vessels - pathology | Diet, High-Fat - adverse effects | Sciatic Nerve - physiopathology | Insulin - blood | Nervous System - physiopathology | Blood Vessels - physiopathology | Dose-Response Relationship, Drug | Sciatic Nerve - metabolism | Leptin - blood | Superoxides - metabolism | Sciatic Nerve - drug effects | Diabetes Complications - pathology | Glucose Tolerance Test | Nerve Fibers - drug effects | Organ Size - drug effects | Animals | Nervous System - drug effects | Blood Vessels - drug effects | Muscle, Skeletal - pathology | Complications and side effects | Obesity | Insulin resistance | Angiotensin | Animal models | Arterioles | Streptozocin | Diabetes mellitus | Insulin | Fibers | High fat diet | Calcitonin gene-related peptide | Nerve conduction | Peptidyl-dipeptidase A | Acetylcholine | Neprilysin | Sciatic nerve | vasopeptidase inhibitor | vascular relaxation | angiotensin converting enzyme | neutral endopeptidase | diabetic neuropathy | diabetes
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 05/2017, Volume 9, Issue 392, p. eaal3447
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2016, Volume 791, pp. 377 - 388
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2017, Volume 23, Issue 3, pp. 355 - 360
Journal Article
Journal Article