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PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0206244
RIP2, one of the RIP kinases, interacts with p75 neurotrophin receptor, regulating the neuron survival, and with NOD1 and NOD2 proteins, causing the innate... 
MULTIDISCIPLINARY SCIENCES | DISEASE | N-15 | RELAXATION | COUPLINGS | NOD2 | CELL-DEATH | Amino Acid Sequence | Nod1 Signaling Adaptor Protein - chemistry | Magnetic Resonance Spectroscopy - methods | Nod2 Signaling Adaptor Protein - chemistry | Protein Multimerization | Protein Refolding | Models, Molecular | Nod2 Signaling Adaptor Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Static Electricity | Nod1 Signaling Adaptor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Sequence Homology, Amino Acid | Nod2 Signaling Adaptor Protein - metabolism | Solutions | Receptor-Interacting Protein Serine-Threonine Kinase 2 - chemistry | Protein Binding | Caspase Activation and Recruitment Domain | Hydrogen-Ion Concentration | Nod1 Signaling Adaptor Protein - genetics | Physiological aspects | Genetic aspects | Research | Properties | Structure | Protein kinases | Protein-protein interactions | Gram-positive bacteria | Homology | Drug development | Kinases | pH effects | Neurogenesis | Inflammatory diseases | Magnetic resonance spectroscopy | Proteins | Oligomers | Protein folding | Neurodegeneration | Nod1 protein | NOD2 protein | Immune system | Cell survival | Oligomerization | Immune response | Caspase | Electrostatic properties | Physics | Domains | Chemistry | Protein expression | Protein interaction | NMR spectroscopy | Protein structure
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 789 - 801
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation. Here, we report that cIAP1... 
MOLIMMUNO | CELLS | ACTIVATION | C-IAP1 | PROTEIN | DROSOPHILA IMD PATHWAY | IN-VIVO | KINASE | IMMUNOLOGY | POLYUBIQUITINATION | NF-KAPPA-B | RIP2 | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Pattern Recognition - immunology | Inhibitor of Apoptosis Proteins - genetics | Nod1 Signaling Adaptor Protein - agonists | Colitis - pathology | Baculoviral IAP Repeat-Containing 3 Protein | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Receptors, Pattern Recognition - agonists | Nod2 Signaling Adaptor Protein - agonists | Inhibitor of Apoptosis Proteins - metabolism | Colitis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | Ubiquitination - immunology | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Colitis - enzymology | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - immunology | Mice | Ubiquitin | Oligomers | Ligases | Physiological aspects | Crohn's disease | Colitis | Apoptosis | Medical research | Enzymes | Statistical analysis | Cytokines | Kinases | Proteins | Inflammatory bowel disease | Genotype & phenotype | Insects | Bacteria | Gram-negative bacteria | Chemokines | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97675
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to... 
3T3-L1 ADIPOCYTES | INDEPENDENT MECHANISM | ACTIVATION | RECOGNITION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ENDOTOXEMIA | MICROBIOTA | NF-KAPPA-B | INDUCED INSULIN-RESISTANCE | INNATE IMMUNITY | Lipolysis - drug effects | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gonads - drug effects | Nod1 Signaling Adaptor Protein - deficiency | Adipose Tissue - cytology | Adipocytes - cytology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Adipocytes - drug effects | Adipose Tissue - metabolism | Gonads - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | 3T3-L1 Cells | Mice, Knockout | Gonads - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Adipocytes - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Peptidoglycan - pharmacology | Adipose Tissue - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Nod1 Signaling Adaptor Protein - genetics | Obesity | Metabolites | Insulin resistance | Inflammation | Lipase | Phosphotransferases | Protein binding | Protein kinase A | Pediatrics | Transcription factors | Adipose tissue | Pollution load | Lipids | Activation | Biochemistry | Hormones | Adipocytes | Glucose | Kinases | Defects | Proteins | Receptors | Microbiota | Nutrient loading | Rodents | Animal tissues | Bacteria | Inhibition | Nod1 protein | Endotoxemia | Explants | Cues | Pathogens | NF-κB protein | Oligomerization | Cytokines | Hyperlipidemia | Peptidoglycans | Extracellular signal-regulated kinase | c-Jun protein | Glycerol | MAP kinase | Metabolism | Insulin | Lipolysis | Ligands
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2017, Volume 199, Issue 3, pp. 1196 - 1205
Nucleotide-binding oligomerization domain (Nod)-containing proteins Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes,... 
ADAPTIVE IMMUNITY | HUMAN DENDRITIC CELLS | PEPTIDOGLYCAN | NOD-LIKE RECEPTORS | RECOGNITION | INNATE | IMMUNOLOGY | VERSUS-HOST-DISEASE | EXPRESSION | NEGATIVE REGULATOR | TRANSPLANTATION | T-Lymphocytes - physiology | Nod2 Signaling Adaptor Protein - deficiency | Proto-Oncogene Proteins c-mdm2 - genetics | Receptors, Pattern Recognition - immunology | Nod1 Signaling Adaptor Protein - deficiency | Nod2 Signaling Adaptor Protein - genetics | Graft vs Host Disease - immunology | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Isoantigens - immunology | Cell Death | Genes, p53 - immunology | Proto-Oncogene Proteins c-mdm2 - metabolism | Disease Models, Animal | Adaptive Immunity | Signal Transduction | Lymphocyte Activation | Down-Regulation | Genes, p53 - genetics | Immunity, Innate | Animals | Proto-Oncogene Proteins c-mdm2 - immunology | Nod2 Signaling Adaptor Protein - metabolism | T-Lymphocytes - immunology | Mice | Nod1 Signaling Adaptor Protein - genetics | Graft-versus-host reaction | Syngeneic grafts | p53 Protein | Bone marrow transplantation | Activation | Transplantation | Lymphocytes T | Immunity | Proteins | Receptors | Cell activation | Lymphocytes | Bone marrow | Nod1 protein | NOD2 protein | Immune system | Binding | MDM2 protein | Immune response | Oligomerization | Mortality | Inflammation | T cell receptors | Adaptive immunity | Pattern recognition | Signaling | Cell death | Apoptosis | Inoculum
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 10, pp. 6890 - 6902
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 03/2013, Volume 39, Issue 3, pp. 180 - 187
► Three goldfish Nod-like receptors, gfNod1, gfNod2 and gfNlrx1 were cloned and fully sequenced. ► Gene expression analyses were done in different tissues and... 
Nlrx1 | Mycobacterium | Nod receptors | Antimicrobial-response | Aeromonas | Fish | Nod2 | Nod1 | NLRs | Gene expression | Macrophage | MOLECULAR CHARACTERIZATION | FUNCTIONAL-CHARACTERIZATION | NUCLEOTIDE-BINDING | IMMUNOLOGY | IDENTIFICATION | NEUTROPHIL RECRUITMENT | FISHERIES | PEPTIDOGLYCAN | ZOOLOGY | TOLL-LIKE RECEPTORS | RECOGNITION RECEPTORS | PROTEINS | EXPRESSION | Gram-Negative Bacterial Infections - immunology | Nod2 Signaling Adaptor Protein - genetics | Mitochondrial Proteins - genetics | Phylogeny | Lipopolysaccharides - immunology | Nod1 Signaling Adaptor Protein - metabolism | CARD Signaling Adaptor Proteins - genetics | Fish Proteins - genetics | Mitochondrial Proteins - metabolism | Cloning, Molecular | Apoptosis Regulatory Proteins - genetics | Poly I-C - immunology | Mycobacterium Infections, Nontuberculous - immunology | Gram-Negative Bacterial Infections - veterinary | Macrophages - immunology | Macrophages - microbiology | Immunity, Active | Fish Proteins - immunology | Gene Expression Regulation - immunology | Cells, Cultured | Fish Proteins - metabolism | Nod2 Signaling Adaptor Protein - immunology | Nod1 Signaling Adaptor Protein - immunology | Goldfish - immunology | Aeromonas salmonicida - immunology | Sequence Alignment | Animals | Mycobacterium marinum - immunology | Nod2 Signaling Adaptor Protein - metabolism | Mycobacterium Infections, Nontuberculous - veterinary | Goldfish - microbiology | Adaptor Proteins, Signal Transducing - genetics | Vaccines, Attenuated | Mitochondrial Proteins - immunology | Nod1 Signaling Adaptor Protein - genetics | Macrophages | Fishes
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2005, Volume 74, Issue 1, pp. 355 - 383
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | nuclear factor kappa B (NF-kappa B) | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | BACTERIAL PEPTIDOGLYCAN | SELF-ASSOCIATION | PROCASPASE-9 | interleukin-1 beta | CARD PROTEIN | SYNDROME | OLIGOMERIZATION | NF-KAPPA-B | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2007, Volume 178, Issue 4, pp. 2380 - 2386
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 05/2018, Volume 62, Issue 9, pp. e1700814 - n/a
Scope Flaxseed oil is a rich source of α‐linolenic acid (ALA), which is the precursor of the long‐chain n‐3 polyunsaturated fatty acids (PUFAs), including... 
flaxseed oil | weaned pigs | necroptosis signaling pathway | lipopolysaccharide | inflammation | intestinal barrier function | MEDIATED INFLAMMATION | ALKALINE-PHOSPHATASE | FOOD SCIENCE & TECHNOLOGY | ULCERATIVE-COLITIS | BARRIER FUNCTION | INDUCED LIVER-INJURY | CELL-DEATH | TIGHT JUNCTIONS | POLYUNSATURATED FATTY-ACIDS | FISH-OIL | MICE | Intestines - drug effects | Enterocolitis, Necrotizing - blood | alpha-Linolenic Acid - adverse effects | Intestinal Mucosa - metabolism | Body Weight | Apoptosis - drug effects | Weaning | Enterocolitis, Necrotizing - metabolism | alpha-Linolenic Acid - therapeutic use | Male | Nod2 Signaling Adaptor Protein - genetics | Protective Agents - therapeutic use | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Intestinal Mucosa - drug effects | Intestines - immunology | Intestinal Mucosa - growth & development | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Intestinal Mucosa - immunology | Protective Agents - adverse effects | Linseed Oil - adverse effects | Lipopolysaccharides - toxicity | Signal Transduction | Enterocolitis, Necrotizing - prevention & control | Gene Expression Regulation, Developmental - drug effects | Intestines - growth & development | Toll-Like Receptor 4 - genetics | Linseed Oil - therapeutic use | Orchiectomy - veterinary | Random Allocation | Toll-Like Receptor 4 - metabolism | Animals | Nod2 Signaling Adaptor Protein - metabolism | Enterocolitis, Necrotizing - chemically induced | alpha-Linolenic Acid - metabolism | Sus scrofa | Crosses, Genetic | Nod1 Signaling Adaptor Protein - genetics | Animal experimentation | Oligomers | RNA | Swine | Linolenic acids | Inflammation | Mitogens | Protein kinases | Omega-3 fatty acids | Protein binding | Polyunsaturated fatty acids | Kinases | Docosahexaenoic acid | Blood | Lipopolysaccharides | Proteins | Signal transduction | Receptors | Corn oil | Pathways | Intestine | Toll-like receptors | Supplementation | Nod1 protein | NOD2 protein | Oligomerization | Lactase | Adapters | Dietary supplements | TLR4 protein | Gene expression | Fatty acids | Signaling | Linolenic acid | Oil | Diet | Protein kinase | Morphology | MyD88 protein | Fats and oils | Eicosapentaenoic acid
Journal Article