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Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7599, pp. 394 - 397
Endoplasmic reticulum (ER) stress is a major contributor to inflammatory diseases, such as Crohn's disease and type 2 diabetes(1,2). ER stress induces the... 
RESPONSES | ACTIVATION | PATHOGEN | MULTIDISCIPLINARY SCIENCES | KINASE | IRE1 | MICE | INFECTION | ENDOPLASMIC-RETICULUM STRESS | NF-KAPPA-B | IV SECRETION SYSTEM | Inflammation - chemically induced | Humans | Male | NF-kappa B - metabolism | Endoribonucleases - antagonists & inhibitors | Nod1 Signaling Adaptor Protein - metabolism | Taurochenodeoxycholic Acid - pharmacology | Endoplasmic Reticulum - pathology | Receptors, Pattern Recognition - metabolism | Inflammation - metabolism | Brucella abortus - immunology | Endoplasmic Reticulum - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Brucella abortus - pathogenicity | Dithiothreitol - pharmacology | Cell Line | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | TNF Receptor-Associated Factor 2 - metabolism | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Animals | Bacterial Outer Membrane Proteins - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Interleukin-6 - biosynthesis | Thapsigargin - pharmacology | Mice | NOD-like receptors | Physiological research | Inflammation | Bacterial infections | Research | Endoplasmic reticulum | Signal transduction | Cytokines | Ligands | Infections | Kinases | Apoptosis | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2010, Volume 11, Issue 1, pp. 55 - 62
Journal Article
Diabetes, ISSN 0012-1797, 09/2011, Volume 60, Issue 9, pp. 2206 - 2215
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 789 - 801
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation. Here, we report that cIAP1... 
MOLIMMUNO | CELLS | ACTIVATION | C-IAP1 | PROTEIN | DROSOPHILA IMD PATHWAY | IN-VIVO | KINASE | IMMUNOLOGY | POLYUBIQUITINATION | NF-KAPPA-B | RIP2 | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Pattern Recognition - immunology | Inhibitor of Apoptosis Proteins - genetics | Nod1 Signaling Adaptor Protein - agonists | Colitis - pathology | Baculoviral IAP Repeat-Containing 3 Protein | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Receptors, Pattern Recognition - agonists | Nod2 Signaling Adaptor Protein - agonists | Inhibitor of Apoptosis Proteins - metabolism | Colitis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | Ubiquitination - immunology | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Colitis - enzymology | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - immunology | Mice | Ubiquitin | Oligomers | Ligases | Physiological aspects | Crohn's disease | Colitis | Apoptosis | Medical research | Enzymes | Statistical analysis | Cytokines | Kinases | Proteins | Inflammatory bowel disease | Genotype & phenotype | Insects | Bacteria | Gram-negative bacteria | Chemokines | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Bacteria | Peptides | Kinases | Immune system | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7499, pp. 240 - 244
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2012, Volume 46, Issue 6, pp. 746 - 758
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2007, Volume 8, Issue 2, pp. 198 - 205
Journal Article
Nature Immunology, ISSN 1529-2908, 10/2009, Volume 10, Issue 10, pp. 1073 - 1080
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2015, Volume 58, Issue 3, pp. 507 - 521
IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through an unknown mechanism. Here, we show how IRGM... 
UBIQUITINATION | ACTIVATION | BECLIN 1 | CROHNS-DISEASE | PHOSPHATIDYLINOSITOL 3-KINASE | TUBERCULOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | ULK1 | NOD2 | ASSOCIATION | CELL BIOLOGY | Crohn Disease - genetics | Autophagy-Related Proteins | Anti-Infective Agents - metabolism | Humans | Crohn Disease - metabolism | Nod2 Signaling Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | GTP-Binding Proteins - genetics | Autophagy-Related Protein-1 Homolog | Receptors, Pattern Recognition - metabolism | Ubiquitination | RNA Interference | U937 Cells | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Gene Expression | Membrane Proteins - genetics | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | HT29 Cells | Carrier Proteins - genetics | Microscopy, Confocal | Carrier Proteins - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Cell Line, Tumor | Protein Binding | Receptors, Pattern Recognition - genetics | HeLa Cells | GTP-Binding Proteins - metabolism | Molecular genetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7444, pp. 233 - 237
Journal Article