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Journal Article
JOURNAL OF THE ROYAL SOCIETY INTERFACE, ISSN 1742-5689, 09/2017, Volume 14, Issue 134, p. 20170213
The coefficient of determination R-2 quantifies the proportion of variance explained by a statistical model and is an important summary statistic of biological... 
REGRESSION | GENETIC-ANALYSIS | PRACTICAL GUIDE | MULTIDISCIPLINARY SCIENCES | model fit | DELTA METHOD | heritability | repeatability | NONLINEAR MODELS | EVOLUTION | reliability analysis | EXPONENTIAL-FAMILIES | OVERDISPERSED COUNT DATA | ECOLOGY | VARIANCE | goodness of fit | variance decomposition | Models, Biological
Journal Article
Computational Statistics and Data Analysis, ISSN 0167-9473, 2005, Volume 49, Issue 4, pp. 1020 - 1038
A stochastic approximation version of EM for maximum likelihood estimation of a wide class of nonlinear mixed effects models is proposed. The main advantage of... 
Maximum likelihood estimation | SAEM algorithm | Mixed effects model | Nonlinear model | EM algorithm | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | APPROXIMATION | nonlinear model | VERSION | CONVERGENCE | STATISTICS & PROBABILITY | maximum likelihood estimation | mixed effects model | Analysis | Models | Algorithms
Journal Article
Journal of Statistical Software, ISSN 1548-7660, 2017, Volume 80, Issue 3, pp. i03 - 41
Journal Article
JOURNAL OF STATISTICAL SOFTWARE, ISSN 1548-7660, 08/2017, Volume 80, Issue 3, pp. 1 - 41
The saemix package for R provides maximum likelihood estimates of parameters in nonlinear mixed effect models, using a modern and efficient estimation... 
TESTS | MAXIMUM-LIKELIHOOD | OPTIMAL-DESIGN | APPROXIMATION | theophylline | pharmacodynamics | STATISTICS & PROBABILITY | INFORMATION MATRIX | nonlinear mixed effect models | orange tree | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | pharmacokinetics | stochastic approximation EM algorithm | CONVERGENCE | S4 classes
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 12/2016, Volume 43, Issue 6, pp. 583 - 596
Journal Article
Computer Methods and Programs in Biomedicine, ISSN 0169-2607, 03/2018, Volume 156, pp. 217 - 229
Journal Article
Journal of Applied Statistics, ISSN 0266-4763, 01/2018, Volume 45, Issue 2, pp. 320 - 346
Journal Article
Pharmaceutical Statistics, ISSN 1539-1604, 01/2017, Volume 16, Issue 1, pp. 45 - 54
Journal Article
Computational Statistics and Data Analysis, ISSN 0167-9473, 07/2019, Volume 135, pp. 107 - 122
Mixed effects models are widely used to describe heterogeneity in a population. A crucial issue when adjusting such a model to data consists in identifying... 
Chi-bar-square distribution | Inference under constraints | Hypothesis testing | Nonlinear mixed effects models | Variance components | Likelihood ratio test | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | SCORE | MATRICES | STATISTICS & PROBABILITY | PERMUTATION TESTS | PLANT-GROWTH | Statistics | Mathematics
Journal Article
Computational Statistics and Data Analysis, ISSN 0167-9473, 12/2015, Volume 92, pp. 26 - 39
Bayesian inference has commonly been performed on nonlinear mixed effects models. However, there is a lack of research into performing Bayesian optimal design... 
Sampling strategies | Bayesian optimal design | Nonlinear mixed effects models | Population design | Stochastic optimisation | REGRESSION | PHARMACOKINETIC DATA | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | STATISTICS & PROBABILITY | OPTIMAL SAMPLING TIMES | Neurosciences | Analysis | Models
Journal Article
Computational Statistics and Data Analysis, ISSN 0167-9473, 12/2014, Volume 80, pp. 57 - 69
Journal Article