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Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2014, Volume 90, Issue 3, pp. 288 - 296
Inhibition of 17α-hydroxylase/17,20-lyase (CYP17), which dictates the proceeding of androgen biosynthesis, is recommended as an effective treatment for... 
Polyphenol | CYP17 inhibitor | Androgen depletion | Corticosteroid elevation | RESVERATROL | STEROIDOGENESIS | CYTOCHROME-P450 | SUPPORT | PATHWAY | PROSTATE-CANCER | CARDIOVASCULAR-DISEASE | ANDROGEN | REDUCTASE | PHARMACOLOGY & PHARMACY | P450 | Stilbenes - adverse effects | Gene Expression Regulation, Enzymologic - drug effects | Microsomes - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Adrenal Cortex Hormones - antagonists & inhibitors | Humans | Adrenal Cortex - metabolism | Adrenal Cortex Hormones - secretion | Hydrocortisone - secretion | Polyphenols - pharmacology | Hydrocortisone - metabolism | Steroid 21-Hydroxylase - metabolism | Dehydroepiandrosterone - agonists | Stilbenes - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Androgens - agonists | Microsomes - drug effects | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Adrenal Cortex - secretion | Nonsteroidal Anti-Androgens - adverse effects | Steroid 21-Hydroxylase - antagonists & inhibitors | Steroid 21-Hydroxylase - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Adrenal Cortex Hormones - metabolism | Adrenal Cortex - drug effects | Dehydroepiandrosterone - metabolism | Nonsteroidal Anti-Androgens - pharmacology | Enzyme Inhibitors - adverse effects | Cell Line | Androgens - secretion | Enzyme Inhibitors - pharmacology | Microsomes - enzymology | Hydrocortisone - agonists | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Adrenal Cortex Hormones - agonists | Aldo-Keto Reductase Family 1 Member C3 | Androgens - chemistry | Polyphenols - adverse effects | Steroid 17-alpha-Hydroxylase - genetics | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Androgens - metabolism | Dehydroepiandrosterone - secretion | Hydrocortisone - antagonists & inhibitors | Polyphenols | Corticosteroids | Analysis | Cytochrome P-450
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2013, Volume 365, Issue 1, pp. 95 - 107
► The effect of bicalutamide is corrupted by FoxA1 while that of MDV3100 is reduced. ► MDV3100-AR complex binds specifically to the androgen response elements... 
FoxA1 | Chromatin presetting | Bicalutamide | MDV3100 (Enzalutamide) | Xenopus oocyte | Androgen receptor | GLUCOCORTICOID-RECEPTOR BINDING | DNA-BINDING | CHROMATIN-STRUCTURE | ACETYLATION | CELL BIOLOGY | ANDROGEN-RECEPTOR | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MMTV PROMOTER | RESISTANT PROSTATE-CANCER | TRANSCRIPTIONAL REGULATION | EXPRESSION | Anilides - adverse effects | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Hepatocyte Nuclear Factor 3-alpha - antagonists & inhibitors | Protein Transport - drug effects | Tosyl Compounds - pharmacology | Antineoplastic Agents, Hormonal - adverse effects | Oocytes - cytology | Prostate - pathology | Cell Nucleus - metabolism | RNA Interference | Oocytes - drug effects | Prostate - drug effects | Nonsteroidal Anti-Androgens - metabolism | Neoplasm Proteins - genetics | Prostatic Neoplasms - drug therapy | Phenylthiohydantoin - pharmacology | Recombinant Proteins - antagonists & inhibitors | Oocytes - metabolism | Tosyl Compounds - adverse effects | Receptors, Androgen - genetics | Anilides - pharmacology | Cell Line, Tumor | Nitriles - adverse effects | Phenylthiohydantoin - metabolism | Prostatic Neoplasms - metabolism | Nitriles - pharmacology | Receptors, Androgen - metabolism | Neoplasm Proteins - metabolism | Antineoplastic Agents, Hormonal - metabolism | Chromatin Assembly and Disassembly - drug effects | Prostate - metabolism | Nonsteroidal Anti-Androgens - adverse effects | HEK293 Cells | Female | Nonsteroidal Anti-Androgens - pharmacology | Recombinant Proteins - metabolism | Nitriles - metabolism | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Xenopus laevis | Anilides - metabolism | Hepatocyte Nuclear Factor 3-alpha - genetics | Phenylthiohydantoin - analogs & derivatives | Hepatocyte Nuclear Factor 3-alpha - metabolism | Animals | Tosyl Compounds - metabolism | Cell Nucleus - drug effects | Nucleases | Chromatin | Corticosteroids | Estrogen | Triamcinolone | DNA-ligand interactions | Amphibians | Biomedical materials | Deoxyribonucleic acid | In vivo testing | In vivo tests | Attenuation | Nuclei | Prostate | Cancer
Journal Article
Journal Article
Journal of Geriatric Oncology, ISSN 1879-4068, 2014, Volume 5, Issue 4, pp. 343 - 351
Journal Article
Archives of Toxicology, ISSN 0340-5761, 12/2017, Volume 91, Issue 12, pp. 3961 - 3989
Journal Article
American Journal of Case Reports, ISSN 1941-5923, 06/2014, Volume 15, pp. 266 - 270
Male, 81 FINAL DIAGNOSIS: Prostate cancer Symptoms: Anorexia • dark urine • joundice • letargy Casodex Clinical Procedure: - Specialty: Oncology. Adverse... 
Drug-induced liver injury | Prostatic neoplasms | Nonsteroidal anti-androgens
Journal Article
Best Practice & Research: Clinical Endocrinology & Metabolism, ISSN 1521-690X, 2008, Volume 22, Issue 2, pp. 331 - 340
Maximal androgen blockade (MAB) refers to the combination of medical (gonadotrophin-releasing hormone agonist) or surgical castration with an anti-androgen for... 
Endocrinology & Metabolism | prostate cancer | anti-androgens | androgen receptor | maximal androgen blockade | TRIALS | METAANALYSIS | MONOTHERAPY | FLUTAMIDE | WITHDRAWAL SYNDROME | BICALUTAMIDE | NONSTEROIDAL ANTIANDROGENS | THERAPY | ENDOCRINOLOGY & METABOLISM | CARCINOMA | AGONIST | Meta-Analysis as Topic | Anilides - adverse effects | Humans | Androgen Antagonists - economics | Male | Dose-Response Relationship, Drug | Nitriles - administration & dosage | Orchiectomy - adverse effects | Antineoplastic Agents, Hormonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - economics | Antineoplastic Agents, Hormonal - economics | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Tosyl Compounds - administration & dosage | Antineoplastic Agents, Hormonal - administration & dosage | Combined Modality Therapy - adverse effects | Withholding Treatment | Disease Progression | Prostatic Neoplasms - mortality | Randomized Controlled Trials as Topic | Tosyl Compounds - adverse effects | Anilides - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Androgen Antagonists - administration & dosage | Neoplasms, Hormone-Dependent - drug therapy | Androgen Antagonists - adverse effects | Neoplasm Staging | Nitriles - adverse effects | Orchiectomy - methods | Prostate cancer | Index Medicus
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1/2017, Volume 91, Issue 1, pp. 143 - 162
Prochloraz is an imidazole fungicide, and its regulatory toxicological data package has been primarily generated in the 1990s. More recently, studies have been... 
Biomedicine, general | Prochloraz | Reference value | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Low dose | Anti-androgenicity | Pharmacology/Toxicology | Reproductive toxicology | ENDOCRINE-DISRUPTING CHEMICALS | NONMONOTONIC DOSE-RESPONSES | MALE-RAT | H295R CELLS | PESTICIDES | IN-VITRO | FUNGICIDE PROCHLORAZ | TOXICOLOGY | PARTURITION | FEED RESTRICTION | RISK-ASSESSMENT | Prenatal Exposure Delayed Effects | Lactation | Models, Chemical | Rats, Wistar | Fungicides, Industrial - toxicity | Imidazoles - administration & dosage | Male | Dose-Response Relationship, Drug | Puberty, Delayed - blood | Fetal Resorption - blood | Fetal Resorption - chemically induced | Urogenital Abnormalities - chemically induced | Female | Weight Gain - drug effects | Imidazoles - toxicity | Ecotoxicology - legislation & jurisprudence | Fetal Growth Retardation - blood | Nonsteroidal Anti-Androgens - toxicity | Ecotoxicology - methods | Administration, Oral | Fungicides, Industrial - blood | Endocrine Disruptors - blood | Random Allocation | Endocrine Disruptors - administration & dosage | Endocrine Disruptors - toxicity | Nonsteroidal Anti-Androgens - administration & dosage | Pregnancy | Toxicokinetics | Imidazoles - blood | Animals | Fetal Growth Retardation - chemically induced | Urogenital Abnormalities - blood | Puberty, Delayed - chemically induced | Nonsteroidal Anti-Androgens - blood | Fungicides, Industrial - standards | Safety regulations | Safety and security measures | Pregnant women | Body weight | Food | Fungi | Comparative studies | Androgens | Hormones | Neurons | Index Medicus
Journal Article
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 04/2017, Volume 194, pp. 9 - 21
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2014, Volume 278, Issue 3, pp. 201 - 208
Many xenobiotics have been identified as androgen receptor (AR) antagonists, but information about their ability to produce combined effects at low... 
Endocrine disruption | AR antagonism | Mixture | Anti-androgen | Concentration addition | REPRODUCTIVE MALFORMATIONS | RECEPTOR AGONISTS | CRYPTORCHIDISM | PREVALENCE | HUMAN EXPOSURE | SEXUAL-DIFFERENTIATION | DYSGENESIS | PREGNANT-WOMEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HYPOSPADIAS | UV FILTERS | Nonsteroidal Anti-Androgens - toxicity | Risk Assessment - methods | Consumer Product Safety | Humans | Receptors, Androgen - metabolism | Dihydrotestosterone - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Recombinant Fusion Proteins - metabolism | Endocrine Disruptors - toxicity | Antioxidants - toxicity | Response Elements - drug effects | Drug Interactions | Osmolar Concentration | Receptors, Androgen - genetics | Androgens - pharmacology | Models, Biological | Pesticides - toxicity | Cell Line, Tumor | Androgens - chemistry | Dihydrotestosterone - pharmacology | Genes, Reporter - drug effects | Receptors, Androgen - chemistry | Industrial Waste - adverse effects | Environmental Pollutants - toxicity | Antioxidants | Toiletries | Bisphenol-A | Surface active agents | Epoxy resins | Pesticides | Environmental aspects | Hormones, Sex | Pollutants | Index Medicus | PYRENE | ANTIOXIDANTS | FILTERS | EVALUATION | IN VIVO | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | PESTICIDES | MIXTURES | XENOBIOTICS | RISK ASSESSMENT | IN VITRO | GENES | ANDROGENS | RECEPTORS
Journal Article