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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 19, pp. 8003 - 8008
Dengue virus (DENV) causes the major arboviral disease of the tropics, characterized in its severe forms by signs of hemorrhage and plasma leakage. DENV... 
Molecules | Lipoproteins | Secretion | Dengue | HDL lipoproteins | Lipids | Triglycerides | Dengue virus | Detergents | Fatty acids | Amphiphilic proteins | Dengue hemorrhagic fever | Arbovirus | amphiphilic proteins | CELLS | RNA | FORM | GLYCOPROTEIN NS1 | MULTIDISCIPLINARY SCIENCES | arbovirus | PATHOGENESIS | dengue hemorrhagic fever | secretion | LIPID PROFILE | ENCEPHALITIS | WEST-NILE | FEVER | REVEALS | Cell Line | Protein Subunits | Recombinant Proteins - ultrastructure | Drosophila | Humans | Protein Multimerization | Dengue Virus - ultrastructure | Cercopithecus aethiops | Models, Molecular | Recombinant Proteins - chemistry | Dengue Virus - chemistry | Cryoelectron Microscopy | Lipoproteins, HDL - ultrastructure | Viral Nonstructural Proteins - chemistry | Animals | Computer Simulation | HEK293 Cells | Protein Structure, Quaternary | Lipoproteins, HDL - chemistry | Nuclear Magnetic Resonance, Biomolecular | Imaging, Three-Dimensional | Viral Nonstructural Proteins - ultrastructure | Vero Cells | Dengue viruses | Genetic aspects | Lipid metabolism | Viral Nonstructural Proteins/ultrastructure | Lipoproteins, HDL/ultrastructure | Life Sciences | Recombinant Proteins/chemistry | Lipoproteins, HDL/chemistry | Viral Nonstructural Proteins/chemistry | Dengue Virus/ultrastructure | Dengue Virus/chemistry | Recombinant Proteins/ultrastructure | Microbiology and Parasitology | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 11/2012, Volume 338, Issue 6108, pp. 810 - 814
Fluorescent proteins (FPs) are widely used as optical sensors, whereas other light-absorbing domains have been used for optical control of protein localization... 
Proteins | Enzymes | Delta cells | NIH 3T3 cells | REPORTS | Fluorescence | Pseudopodia | Dimers | Cell membranes | Optical control | P branes | SPATIOTEMPORAL CONTROL | ACTIVATION | GTPASES | MULTIDISCIPLINARY SCIENCES | LIGHT | INDUCTION | EXCHANGE FACTORS | LOV DOMAIN | LIVING CELLS | MOTILITY | Darkness | NIH 3T3 Cells | Pseudopodia - ultrastructure | Native Polyacrylamide Gel Electrophoresis | Humans | Protein Multimerization | Adaptor Proteins, Vesicular Transport - genetics | Optogenetics | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Viral Nonstructural Proteins - chemistry | Light | Protein Engineering | Serine Endopeptidases - genetics | Luminescent Proteins - chemistry | Adaptor Proteins, Vesicular Transport - chemistry | Cell Membrane - metabolism | Protein Structure, Tertiary | Models, Molecular | Viral Nonstructural Proteins - genetics | Serine Endopeptidases - chemistry | Recombinant Fusion Proteins - chemistry | Animals | Pseudopodia - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Protein Conformation | Viral Nonstructural Proteins - metabolism | Mice | Serine Endopeptidases - metabolism | HeLa Cells | Luminescent Proteins - metabolism | Physiological aspects | Photoreception | Research | Fluorescent proteins | Sensors | Cellular biology | Activated | Exposure | Optical sensors | Detection
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2011, Volume 7, Issue 2, p. e1001278
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2013, Volume 9, Issue 4, p. e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1 beta response is mediated by innate receptors in... 
INTERLEUKIN-1 | RNA | RESPIRATORY VIRAL-INFECTION | INNATE IMMUNE-RESPONSE | RIG-I | MICROBIOLOGY | INDUCTION | NS1 PROTEIN | ANTIVIRAL RESPONSES | INTERFERON | VIROLOGY | EPITHELIAL-CELLS | PARASITOLOGY | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Virology | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2017, Volume 292, Issue 44, pp. 18024 - 18043
Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV) RNA genome and therefore is... 
NONNUCLEOSIDE INHIBITORS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | RNA-protein interaction | MOLECULAR-WEIGHT PROTEINS | VIRAL REPLICATION | RELAXATION DISPERSION EXPERIMENTS | REPLICATION COMPARTMENT | METHYL-TROSY | STRUCTURAL BASIS | nuclear magnetic resonance (NMR) | NONSTRUCTURAL PROTEIN | FUZZY COMPLEXES | protein-protein interaction | protein dynamic | Triazoles - chemistry | RNA Replicase - metabolism | RNA Replicase - antagonists & inhibitors | Antiviral Agents - metabolism | Pyrones - pharmacology | Pyrones - chemistry | Viral Nonstructural Proteins - chemistry | Isoleucine - chemistry | Oligoribonucleotides - metabolism | Antiviral Agents - chemistry | Enzyme Inhibitors - chemistry | Gene Deletion | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Oligoribonucleotides - chemistry | Peptide Fragments - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Antiviral Agents - pharmacology | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | RNA Replicase - genetics | Allosteric Site - drug effects | Enzyme Inhibitors - pharmacology | Solubility | Models, Molecular | Protein Refolding - drug effects | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Intrinsically Disordered Proteins - genetics | Triazoles - pharmacology | Point Mutation | Triazoles - metabolism | Hepacivirus - enzymology | Peptide Fragments - chemistry | Intrinsically Disordered Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | RNA Replicase - chemistry | Protein Conformation | Viral Nonstructural Proteins - metabolism | Pyrones - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Intrinsically Disordered Proteins - metabolism | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Molecular Bases of Disease
Journal Article
Journal of Viral Hepatitis, ISSN 1352-0504, 05/2011, Volume 18, Issue 5, pp. 305 - 315
Hepatitis C virus (HCV) nonstructural protein 3‐4A (NS3‐4A) is a complex composed of NS3 and its cofactor NS4A. It harbours serine protease as well as... 
replication | innate immunity | NS3‐4A | directly acting antiviral | hepatitis C virus | helicase | interferon | serine protease | mitochondrial antiviral signalling protein | NS3-4A | INFECTIOUS DISEASES | RIG-I | CELL-LINES | VIRAL REPLICATION | TYROSINE-PHOSPHATASE | NS3 HELICASE | VIROLOGY | ANTIVIRAL SIGNALING PROTEIN | SERINE-PROTEASE | CHRONIC HCV INFECTION | GASTROENTEROLOGY & HEPATOLOGY | ADAPTER PROTEIN | Serine Proteases - genetics | RNA Helicases - metabolism | Humans | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Nucleoside-Triphosphatase - genetics | Mitochondrial Proteins - genetics | RNA Helicases - chemistry | Adaptor Proteins, Vesicular Transport - metabolism | Hepacivirus - metabolism | Serine Proteinase Inhibitors - therapeutic use | Viral Nonstructural Proteins - chemistry | Mitochondrial Proteins - metabolism | Nucleoside-Triphosphatase - metabolism | Carrier Proteins - chemistry | RNA Helicases - genetics | Serine Proteases - chemistry | Serine Proteinase Inhibitors - pharmacology | Nucleoside-Triphosphatase - chemistry | Serine Proteases - metabolism | Antiviral Agents - pharmacology | Signal Transduction | Antiviral Agents - therapeutic use | Mitochondrial Proteins - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Viral Nonstructural Proteins - genetics | Hepatitis C, Chronic - drug therapy | RNA Helicases - antagonists & inhibitors | Nucleoside-Triphosphatase - antagonists & inhibitors | Carrier Proteins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Drug Resistance, Viral - genetics | Hepacivirus - enzymology | Carrier Proteins - metabolism | Virus Replication | Mitochondrial Proteins - chemistry | Viral Nonstructural Proteins - metabolism | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Cellular proteins | Protease inhibitors | RNA | Interferon alpha | Thrombin | Biological response modifiers | Hepatitis C | Hepatitis C virus
Journal Article
Structure, ISSN 0969-2126, 02/2017, Volume 25, Issue 2, pp. 219 - 230
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2013, Volume 9, Issue 8, p. e1003533
The innate immune system is essential for controlling viral infections, but several viruses have evolved strategies to escape innate immunity. RIG-I is a... 
VIRAL-RNA | RECOGNITION | HEPATITIS-C-VIRUS | MICROBIOLOGY | KAPPA-B | SIGNALING PROTEIN | VIROLOGY | STRUCTURAL BASIS | PATHWAY | ADAPTER PROTEIN | HELICASE | PARASITOLOGY | E3 UBIQUITIN LIGASE | Hepatitis C - metabolism | Hepacivirus - immunology | Humans | Cercopithecus aethiops | Hepacivirus - genetics | Mutation, Missense | Hepacivirus - metabolism | Tripartite Motif Proteins | DNA-Binding Proteins - metabolism | Hepatitis C - immunology | Ubiquitin-Protein Ligases - immunology | HEK293 Cells | Ubiquitination - physiology | DEAD-box RNA Helicases - metabolism | Transcription Factors - immunology | Vero Cells | Carrier Proteins - immunology | Viral Nonstructural Proteins - immunology | Protein Structure, Tertiary | DEAD Box Protein 58 | DNA-Binding Proteins - immunology | Ubiquitin-Protein Ligases - metabolism | Viral Nonstructural Proteins - genetics | Hepatitis C - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | Hep G2 Cells | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | DEAD-box RNA Helicases - immunology | Viral Nonstructural Proteins - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Amino Acid Substitution | Antiviral agents | Immune response | Drug interactions | Physiological aspects | Dosage and administration | Research | Ubiquitin-proteasome system | Health aspects | Hepatitis | Infections | Kinases | Viral infections | Immune system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 24, pp. E3403 - E3412
Type I IFNs are key cytokines mediating innate antiviral immunity. cGMP-AMP synthase, ritinoic acid-inducible protein 1 (RIG-I)–like receptors, and Toll-like... 
Signaling | Innate immunity | Type I interferon | Transcription factor | Crystal structure | transcription factor | CYCLIC GMP-AMP | signaling | RECOGNITION | MECHANISM | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DIMERIZATION | type I interferon | 2ND-MESSENGER | innate immunity | crystal structure | DEGRADATION | RECEPTORS | INSIGHTS | Adaptor Proteins, Signal Transducing - chemistry | Humans | Adaptor Proteins, Vesicular Transport - genetics | Rotavirus - immunology | Rotavirus - genetics | CREB-Binding Protein - chemistry | Rotavirus - chemistry | Rotavirus Infections - genetics | Interferon Regulatory Factor-3 - genetics | CREB-Binding Protein - genetics | Viral Nonstructural Proteins - chemistry | Adaptor Proteins, Signal Transducing - immunology | Interferon Regulatory Factor-3 - chemistry | Protein Domains | Adaptor Proteins, Vesicular Transport - chemistry | Interferon Regulatory Factor-3 - immunology | Viral Nonstructural Proteins - immunology | Membrane Proteins - genetics | Viral Nonstructural Proteins - genetics | Membrane Proteins - immunology | Adaptor Proteins, Vesicular Transport - immunology | Immunity, Innate | Amino Acid Motifs | Rotavirus Infections - immunology | Immune Evasion | Membrane Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | CREB-Binding Protein - immunology | Phosphates | Cytokines | Observations | Health aspects | Protein-protein interactions | Immunoproteins | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences | PNAS Plus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 31, pp. 12054 - 12067
Nidovirus endoribonucleases (NendoUs) include nonstructural protein 15 (nsp15) from coronaviruses and nsp11 from arteriviruses, both of which have been... 
PROTEIN | protein evolution | MOUSE HEPATITIS-VIRUS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein purification | viral protein | evolution | REPLICATIVE ENDORIBONUCLEASE | INDUCTION | DISCOVERY | MURINE | endoribonuclease | XENDOU | oligomerization | PDCoV nsp15 | nidovirus | CORONAVIRUS ENDORIBONUCLEASE | Endoribonucleases - chemistry | Coronavirus - classification | Endoribonucleases - genetics | Virus Replication - genetics | Protein Multimerization | Nidovirales - genetics | Crystallography, X-Ray | SARS Virus - metabolism | Protein Subunits - metabolism | SARS Virus - classification | Nidovirales - chemistry | Viral Nonstructural Proteins - chemistry | SARS Virus - genetics | Coronavirus - metabolism | Arterivirus - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Arterivirus - chemistry | Protein Interaction Domains and Motifs | Arterivirus - classification | Binding Sites | Protein Subunits - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Endoribonucleases - metabolism | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Recombinant Proteins - genetics | SARS Virus - chemistry | Arterivirus - genetics | Sequence Homology, Amino Acid | Nidovirales - classification | Sequence Alignment | Coronavirus - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Coronavirus - genetics | Protein Binding | Viral Nonstructural Proteins - metabolism | Nidovirales - metabolism | Protein Subunits - chemistry | Evolution, Molecular | Microbiology
Journal Article