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2007, ISBN 0521834910, xv, 642
This book was first published in 2007. Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS)... 
Noradrenaline | Norepinephrine
Book
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 38, pp. 15810 - 15815
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways... 
Side effects | Receptors | Neurotransmitters | Databases | Drug interactions | Ligands | Norepinephrine | Drug design | Binding sites | Neuroendocrine tumors | GENETIC-VARIATION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | BACTERIAL HOMOLOG | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RELEASE | LEUT | BINDING-SITES | MOLECULAR DOCKING | CONFORMATIONS | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Drug Discovery - methods | Prescription Drugs - metabolism | Norepinephrine - pharmacokinetics | Prescription Drugs - chemistry | Prescription Drugs - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - genetics | HEK293 Cells | Biological Transport - drug effects | Molecular Structure | Protein Structure, Tertiary | Amino Acid Sequence | Computational Biology - methods | Bacterial Proteins - genetics | Models, Molecular | Binding Sites - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Sequence Homology, Amino Acid | Algorithms | Norepinephrine - metabolism | Norepinephrine - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Drugs | Prescribing | Research | Noradrenaline | Health aspects | Biological Sciences | membrane protein | structure-based ligand discovery | comparative modeling | protein function prediction | polypharmacology
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2011, Volume 108, Issue 29, pp. 12137 - 12142
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although... 
Tricyclic antidepressive agents | Antidepressants | Norepinephrine plasma membrane transport proteins | Reuptake | Serotonin plasma membrane transport proteins | Norepinephrine | Enantiomers | Experimental procedures | Binding sites | Chemicals | Monoamine | Neurotransmitter | SLC6 transporter | HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CITALOPRAM | MONOAMINE TRANSPORTERS | monoamine | BACTERIAL HOMOLOG | SUBSTRATE | DOPAMINE | BINDING-SITE | LEUT | neurotransmitter | STRUCTURAL DOMAINS | Humans | Cercopithecus aethiops | Molecular Sequence Data | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | DNA Mutational Analysis | Norepinephrine Plasma Membrane Transport Proteins - genetics | Base Sequence | Radioligand Assay | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Crystallization | Models, Molecular | Binding Sites - genetics | Genetic Vectors - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Propylamines - metabolism | COS Cells | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Benzofurans - metabolism | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 13, pp. 6058 - 6063
Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE... 
Brain | Neurons | Antibodies | Norepinephrine | Mice | Amyloids | Alzheimers disease | Phagocytosis | Locus coeruleus | Microglia | Neuroinflammation | Amyloid beta | Neurodegeneration | SENILE DEMENTIA | phagocytosis | COERULEUS | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | neurodegeneration | DOPAMINE-BETA-HYDROXYLASE | amyloid beta | DEGENERATION | neuroinflammation | NEURONS | NORADRENALINE | BRAIN | TRANSGENIC MICE | Inflammation - pathology | Microglia - metabolism | Norepinephrine - pharmacology | Humans | Cell Movement - physiology | Alzheimer Disease - pathology | Brain - metabolism | Inflammation - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Microglia - pathology | Female | Transcription, Genetic | Disease Models, Animal | Recombinant Proteins - metabolism | Cell Line | Chemokines - biosynthesis | Phagocytosis - drug effects | Microglia - drug effects | Locus Coeruleus - pathology | Phagocytosis - physiology | Mice, Transgenic | Recombinant Proteins - genetics | Cell Movement - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Norepinephrine - metabolism | Alzheimer Disease - metabolism | Brain - pathology | Inflammation - genetics | Norepinephrine - deficiency | Alzheimer Disease - genetics | In Vitro Techniques | Cytokines - biosynthesis | Locus Coeruleus - metabolism | Physiological aspects | Development and progression | Research | Alzheimer's disease | Noradrenaline | Biological Sciences
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43694 - 43707
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30105 - 30113
Background: The contribution of endogenous norepinephrine (NE) to skeletal homeostasis is unclear. Results: Bone forming cells, not only neurons, express the... 
ADHD | SYMPATHETIC-NERVOUS-SYSTEM | HYPERACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Gene Knockout | Osteoblasts | BLOOD-PRESSURE | IMMOBILIZATION | OSTEOPOROSIS | Nerve | Norepinephrine Transporter | Mouse | REGULATES BONE-FORMATION | MASS | Sympathetic Nervous System | Neurotransmitter Transport | MICE | DIFFERENTIATION | BETA-BLOCKERS | Bone Remodeling | Humans | Neurons - cytology | Bone Remodeling - physiology | Osteoclasts - cytology | Sympathetic Nervous System - metabolism | Psychomotor Disorders - metabolism | Psychomotor Disorders - genetics | Biological Transport, Active - physiology | Bone Resorption - genetics | Mice, Mutant Strains | Norepinephrine Plasma Membrane Transport Proteins - genetics | Bone Resorption - metabolism | Antidepressive Agents - pharmacology | Bone Resorption - chemically induced | Neurons - metabolism | Morpholines - adverse effects | Norepinephrine - genetics | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Sympathetic Nervous System - cytology | Psychomotor Disorders - pathology | Morpholines - pharmacology | Osteoclasts - metabolism | Psychomotor Disorders - drug therapy | Animals | Norepinephrine - metabolism | Bone Resorption - pathology | Mice | Antidepressive Agents - adverse effects | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Cell Biology
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 26883
Journal Article
Journal of Affective Disorders, ISSN 0165-0327, 2011, Volume 133, Issue 1, pp. 165 - 173
Abstract Background Catecholamine neurotransmission plays an important role in major depression. Variation in genes implicated in the synthesis and signal... 
Psychiatry | Antidepressant | Depression | Norepinephrine | Dopamine | Stress | Genetic polymorphism | SEROTONIN-DOPAMINE INTERACTION | PROMOTER-POLYMORPHISM | NOREPINEPHRINE TRANSPORTER GENE | ENZYME-ACTIVITY | PSYCHIATRY | TERM TREATMENT RESPONSE | CLINICAL NEUROLOGY | O-METHYLTRANSFERASE COMT | MONOAMINE-OXIDASE-A | PSYCHIATRIC-DISORDERS | MAJOR DEPRESSIVE DISORDER | CLINICAL-RESPONSE | Multifactor Dimensionality Reduction | Synaptic Transmission - physiology | Catecholamines - metabolism | Synaptic Transmission - genetics | Norepinephrine - physiology | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Dopamine - genetics | Depressive Disorder - drug therapy | Male | Monoamine Oxidase - genetics | Catechol O-Methyltransferase - genetics | Depression - genetics | Neurotransmitter Agents - genetics | Norepinephrine Plasma Membrane Transport Proteins - genetics | Adult | Antidepressive Agents - pharmacology | Depressive Disorder, Major - drug therapy | Depressive Disorder - genetics | Dopamine - therapeutic use | Norepinephrine - therapeutic use | Monoamine Oxidase - therapeutic use | Norepinephrine - genetics | Life Change Events | Polymorphism, Genetic | Antidepressive Agents - therapeutic use | Stress, Psychological - genetics | Neurotransmitter Agents - therapeutic use | Depressive Disorder, Major - genetics | Aged | Catecholamines - genetics | Stress (Psychology) | Antidepressants | Noradrenaline | Drug interactions | Depression, Mental
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2016, Volume 139, Issue 2, pp. 197 - 207
Journal Article