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Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
NEUROTRANSMITTER | HIGH-AFFINITY RECOGNITION | MECHANISM | DETERMINANTS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | HUMAN SEROTONIN TRANSPORTER | CHLORIDE | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2014, Volume 454, Issue 1, pp. 25 - 29
A ubiquitous feature of neurotransmitter transporters is the presence of short C-terminal PDZ binding motifs acting as important trafficking elements.... 
PDZ domain | MUPP1 | Neurotransmitter transporters | PDZ motif | LOCALIZATION | COMPLEX | PROTEIN | RECOGNITION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINE TRANSPORTER | BIOPHYSICS | GLYCINE TRANSPORTERS | ASSOCIATION | DEVELOPMENTAL EXPRESSION | BRAIN | Dopamine Plasma Membrane Transport Proteins - metabolism | Glycine Plasma Membrane Transport Proteins - metabolism | Glycine Plasma Membrane Transport Proteins - chemistry | Molecular Sequence Data | Dopamine Plasma Membrane Transport Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Brain - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | GABA Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - genetics | Carrier Proteins - chemistry | Neurotransmitter Transport Proteins - genetics | GABA Plasma Membrane Transport Proteins - chemistry | Amino Acid Sequence | Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Dopamine Plasma Membrane Transport Proteins - genetics | Sequence Homology, Amino Acid | Serotonin Plasma Membrane Transport Proteins - metabolism | Carrier Proteins - genetics | GABA Plasma Membrane Transport Proteins - genetics | Glycine Plasma Membrane Transport Proteins - genetics | Animals | Carrier Proteins - metabolism | PDZ Domains | Recombinant Fusion Proteins - genetics | Mice | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Neurotransmitter Transport Proteins - chemistry | GABA | Glycine | Investigations | Protein binding
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15810 - 15815
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways... 
Side effects | Receptors | Neurotransmitters | Databases | Drug interactions | Ligands | Norepinephrine | Drug design | Binding sites | Neuroendocrine tumors | GENETIC-VARIATION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | BACTERIAL HOMOLOG | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RELEASE | LEUT | BINDING-SITES | MOLECULAR DOCKING | CONFORMATIONS | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Drug Discovery - methods | Prescription Drugs - metabolism | Norepinephrine - pharmacokinetics | Prescription Drugs - chemistry | Prescription Drugs - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - genetics | HEK293 Cells | Biological Transport - drug effects | Molecular Structure | Protein Structure, Tertiary | Amino Acid Sequence | Computational Biology - methods | Bacterial Proteins - genetics | Models, Molecular | Binding Sites - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Sequence Homology, Amino Acid | Algorithms | Norepinephrine - metabolism | Norepinephrine - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Drugs | Prescribing | Research | Noradrenaline | Health aspects | Biological Sciences | membrane protein | structure-based ligand discovery | comparative modeling | protein function prediction | polypharmacology
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43694 - 43707
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 12/2009, Volume 14, Issue 12, pp. 1105 - 1118
We studied seven genes that reflect events relevant to antidepressant action at four sequential levels: (1) entry into the brain, (2) binding to monoaminergic... 
Antidepressant response | Desipramine | Fluoxetine | Major depression | Nucleotide polymorphism | NOREPINEPHRINE TRANSPORTER GENE | MULTILOCUS GENOTYPE DATA | PSYCHIATRY | DEFICIT HYPERACTIVITY DISORDER | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | POLYMORPHISM | DOPAMINE TRANSPORTER | NEUROSCIENCES | desipramine | nucleotide polymorphism | fluoxetine | antidepressant response | POPULATION-STRUCTURE | SEROTONIN | LINKAGE | major depression | ESTIMATING F-STATISTICS | Haplotypes | Humans | Middle Aged | Receptors, Corticotropin-Releasing Hormone - genetics | Male | Receptor, trkB - genetics | Genetic Variation | Psychiatric Status Rating Scales | Serotonin Plasma Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | Norepinephrine Plasma Membrane Transport Proteins - genetics | Adult | Female | ATP Binding Cassette Transporter 1 | Depressive Disorder, Major - drug therapy | Genetic Predisposition to Disease | Pharmacogenetics | Sequence Analysis - methods | Gene Frequency | Dopamine Plasma Membrane Transport Proteins - genetics | Linkage Disequilibrium | Antidepressive Agents - therapeutic use | Cyclic AMP Response Element-Binding Protein - genetics | Mexican Americans - genetics | Membrane Transport Proteins - classification | Depressive Disorder, Major - genetics | Polymorphism, Single Nucleotide - genetics | Antidepressants | Genetic variation | Dosage and administration | Genetic aspects | Research | Drug therapy | Major depressive disorder | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 29, pp. 12137 - 12142
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although... 
Tricyclic antidepressive agents | Antidepressants | Norepinephrine plasma membrane transport proteins | Reuptake | Serotonin plasma membrane transport proteins | Norepinephrine | Enantiomers | Experimental procedures | Binding sites | Chemicals | Monoamine | Neurotransmitter | SLC6 transporter | HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CITALOPRAM | MONOAMINE TRANSPORTERS | monoamine | BACTERIAL HOMOLOG | SUBSTRATE | DOPAMINE | BINDING-SITE | LEUT | neurotransmitter | STRUCTURAL DOMAINS | Humans | Cercopithecus aethiops | Molecular Sequence Data | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | DNA Mutational Analysis | Norepinephrine Plasma Membrane Transport Proteins - genetics | Base Sequence | Radioligand Assay | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Crystallization | Models, Molecular | Binding Sites - genetics | Genetic Vectors - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Propylamines - metabolism | COS Cells | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Benzofurans - metabolism | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1537 - 1541
The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI)... 
Receptors | MicroRNA | Serotonin agents | Neurons | Antidepressants | Serotonin receptors | REPORTS | Cell lines | Serotonin plasma membrane transport proteins | Adrenergic neurons | Locus coeruleus | LOCUS-COERULEUS | CELLS | RECEPTOR | RECOGNITION | RAT | MULTIDISCIPLINARY SCIENCES | Up-Regulation | Protein Biosynthesis | Humans | MicroRNAs - metabolism | Nerve Growth Factors - metabolism | Antidepressive Agents, Second-Generation - administration & dosage | Raphe Nuclei - metabolism | Serotonin Plasma Membrane Transport Proteins - genetics | Neurons - metabolism | 3' Untranslated Regions | Neurons - drug effects | Serotonin Uptake Inhibitors - metabolism | Cell Line | Fluoxetine - pharmacology | S100 Calcium Binding Protein beta Subunit | MicroRNAs - administration & dosage | Depression | S100 Proteins - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine - metabolism | Raphe Nuclei - drug effects | Serotonin Uptake Inhibitors - administration & dosage | Serotonin - metabolism | Fluoxetine - administration & dosage | Fluoxetine - metabolism | Mice | MicroRNAs - genetics | HeLa Cells | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Locus Coeruleus - metabolism | Pharmacogenetics | Serotonin | Physiological aspects | Serotonin uptake inhibitors | Dosage and administration | Research | Health aspects | Pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 1000 - 1013
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2009, Volume 121, Issue 1, pp. 89 - 99
Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these... 
Dopamine transporter | Organic cation transporter | Norepinephrine transporter | Serotonin transporter | Antidepressants | Plasma membrane monoamine transporters | IN-VIVO MICRODIALYSIS | EXTRACELLULAR DOPAMINE | ORGANIC CATION TRANSPORTER-3 | STRIATAL DOPAMINE TERMINALS | PRELIMBIC PREFRONTAL CORTEX | MEMBRANE MONOAMINE TRANSPORTER | DEPRESSION-LIKE BEHAVIOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | Depression - physiopathology | Serotonin Plasma Membrane Transport Proteins - physiology | Equilibrative Nucleoside Transport Proteins - metabolism | Neurotransmitter Transport Proteins - metabolism | Organic Cation Transport Proteins - metabolism | Humans | Organic Cation Transport Proteins - physiology | Drug Discovery | Equilibrative Nucleoside Transport Proteins - physiology | Mice, Knockout - metabolism | Neurotransmitter Transport Proteins - physiology | Antidepressive Agents - therapeutic use | Serotonin Plasma Membrane Transport Proteins - metabolism | Depression - drug therapy | Serotonin Plasma Membrane Transport Proteins - genetics | Animals | Serotonin - metabolism | Neurotransmitter Transport Proteins - drug effects | Antidepressive Agents - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitter Transport Proteins - genetics | plasma membrane monoamine transporters | antidepressants | dopamine transporter | norepinephrine transporter | serotonin transporter | organic cation transporter
Journal Article
NATURE, ISSN 0028-0836, 05/2019, Volume 569, Issue 7754, pp. 141 - 141
The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic... 
SYSTEM | FACING STATE | MOLECULAR-DYNAMICS | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | VALIDATION | GENERAL FORCE-FIELD | X-RAY STRUCTURES | LEUT | BINDING | SOFTWARE NEWS | Binding, Competitive | Hallucinogens - pharmacology | Humans | Protein Conformation - drug effects | Hallucinogens - chemistry | Models, Molecular | Serotonin Plasma Membrane Transport Proteins - ultrastructure | Serotonin Uptake Inhibitors - chemistry | Ibogaine - pharmacology | Structure-Activity Relationship | Cryoelectron Microscopy | Serotonin Plasma Membrane Transport Proteins - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Ibogaine - chemistry | Serotonin - metabolism | Biological Transport - drug effects | Serotonin Uptake Inhibitors - pharmacology | Binding Sites - drug effects | Serotonin | Physiological aspects | Membrane proteins | Competition | Drug abuse | Mental disorders | Disorders | Homeostasis | Homology | Serotonin uptake inhibitors | Helices | Mental depression | Experiments | Ion diffusion | Proteins | Dopamine transporter | Anxiety | Noradrenaline | Dopamine | Narcotics | Attention deficit hyperactivity disorder | Unwinding | Substrate inhibition | Ibogaine | Electron microscopy | Substrates | Genetic variance | Autism | Serotonin transporter | Microscopy | Sodium | Natural products | Cocaine | Norepinephrine | Transport | Transporter | Binding sites | Cytoplasm
Journal Article