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Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 797 - 810
Antibiotic mode-of-action classification is based upon drug-target interaction and whether the resultant inhibition of cellular function is lethal to bacteria.... 
SYSBIO | MICROBIO | OXYGEN | SUPEROXIDE | OXIDATIVE DAMAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | DNA-DAMAGE | HYDROGEN-PEROXIDE | SOS RESPONSE | TRANSCRIPTIONAL REGULATION | GENE ONTOLOGY | IRON-SULFUR CLUSTERS | CELL BIOLOGY | Free Radical Scavengers - pharmacology | Hydroxyurea - pharmacology | Escherichia coli - drug effects | Gene Expression Profiling | Colony Count, Microbial | DNA, Bacterial - drug effects | Norfloxacin - pharmacology | Time Factors | Carbon-Sulfur Lyases - genetics | Escherichia coli - metabolism | Ampicillin - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Escherichia coli - growth & development | Rec A Recombinases - genetics | NAD - metabolism | Staphylococcus aureus - metabolism | 2,2'-Dipyridyl - pharmacology | Staphylococcus aureus - genetics | Rec A Recombinases - metabolism | Microbial Viability - drug effects | Membrane Proteins - genetics | Citric Acid Cycle - drug effects | Escherichia coli Proteins - metabolism | Hydroxyl Radical - metabolism | Carbon-Sulfur Lyases - metabolism | Kanamycin - pharmacology | Hydrogen Peroxide - metabolism | Gene Expression Regulation, Bacterial - drug effects | Citric Acid Cycle - genetics | Anti-Bacterial Agents - classification | Iron Chelating Agents - pharmacology | Escherichia coli - genetics | Ferrous Compounds - metabolism | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | DNA Damage | Mutation | Oxidative Stress - drug effects | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Metabolites | Antibiotics | Index Medicus
Journal Article
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 01/2006, Volume 36, Issue 1, pp. 59 - 69
Summary Background Quinolones are widely used, broad spectrum antibiotics that can induce immediate- and delayed-type hypersensitivity reactions, presumably... 
quinolone | p–i concept | cross-reactivity | delayed hypersensitivity drug reaction | drug-reactive T cells | drug‐reactive T cells | cross‐reactivity | Delayed hypersensitivity drug reaction | p-i concept | Quinolone | Drug-reactive T cells | Cross-reactivity | RECOGNITION | SPECIFICITY | DRUG-SPECIFIC CD4(+) | OFLOXACIN | PROLIFERATION | SULFAMETHOXAZOLE | IMMUNOLOGY | LYMPHOCYTE-TRANSFORMATION TEST | CYTOKINE PROFILE | ALLERGY | CIPROFLOXACIN | CLONES | Fluoroquinolones - chemistry | Humans | Middle Aged | Aza Compounds - pharmacology | Norfloxacin - chemistry | Quinolones - pharmacology | Hypersensitivity, Delayed - immunology | Quinolines - pharmacology | Enoxacin - pharmacology | Ofloxacin - pharmacology | Quinolones - chemistry | Norfloxacin - pharmacology | Anti-Bacterial Agents - chemistry | Nalidixic Acid - chemistry | Nalidixic Acid - pharmacology | Aged, 80 and over | Adult | Female | Clone Cells | Patch Tests | Quinolines - chemistry | Cells, Cultured | Aza Compounds - chemistry | Ciprofloxacin - pharmacology | Pipemidic Acid - pharmacology | Antigen-Presenting Cells - immunology | Cross Reactions | Pipemidic Acid - chemistry | Drug Hypersensitivity - immunology | Fluoroquinolones - pharmacology | Ciprofloxacin - chemistry | Ofloxacin - chemistry | T-Lymphocytes - immunology | Aged | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Enoxacin - chemistry | Allergy | Allergic reaction | Analysis | Index Medicus
Journal Article
JOURNAL OF INORGANIC BIOCHEMISTRY, ISSN 0162-0134, 04/2018, Volume 181, pp. 1 - 10
In this paper, we present a comparative study on the cytotoxic mode of action of copper(I) and copper(II) complexes with phosphine derivatives of... 
Fluoroquinolones | ROS production | SPECTROSCOPIC PROPERTIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CHEMISTRY, INORGANIC & NUCLEAR | OXYGEN | COPPER(I) COMPLEXES | DNA | CHEMISTRY | ANTICANCER COMPLEXES | VITRO ANTITUMOR-ACTIVITY | REDOX MODULATION | ANTIMICROBIAL ACTIVITY | Copper complexes | Apoptosis | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Phosphines - pharmacology | Reactive Oxygen Species - metabolism | Adenocarcinoma of Lung | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Norfloxacin - chemistry | Structure-Activity Relationship | Colonic Neoplasms - metabolism | Reactive Oxygen Species - agonists | Ciprofloxacin - analogs & derivatives | Adenocarcinoma - metabolism | Copper - chemistry | Phosphines - chemistry | Norfloxacin - pharmacology | Anti-Bacterial Agents - chemistry | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Carcinoma - pathology | Carcinoma - drug therapy | Cell Survival - drug effects | Electrochemical Techniques | Chelating Agents - chemistry | Copper - pharmacology | Ciprofloxacin - pharmacology | Chelating Agents - pharmacology | Antineoplastic Agents - chemistry | Adenocarcinoma - drug therapy | Coordination Complexes - chemistry | Animals | Colonic Neoplasms - pathology | Cell Line, Tumor | Ciprofloxacin - chemistry | Anti-Bacterial Agents - pharmacology | Mice | Carcinoma - metabolism | Norfloxacin - analogs & derivatives
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2017, Volume 92, pp. 1111 - 1118
Journal Article
Journal Article
Science of the Total Environment, ISSN 0048-9697, 2005, Volume 349, Issue 1, pp. 95 - 105
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 36, pp. 22287 - 22297
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological... 
HYPOXIA-INDUCIBLE FACTOR | CIPROFLOXACIN THERAPY | BACTERICIDAL ACTIVITY | ACHILLES-TENDON RUPTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUINOLONE ANTIBIOTICS | DISULFIDE-ISOMERASE SUBUNIT | PROLYL HYDROXYLASE REACTION | ACUTE-RENAL-FAILURE | INDUCED TENDINOPATHY | ACUTE INTERSTITIAL NEPHRITIS | Fluoroquinolones - chemistry | Dioxygenases - metabolism | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Immunoblotting | Norfloxacin - chemistry | Iron Chelating Agents - chemistry | Norfloxacin - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Anti-Bacterial Agents - chemistry | HEK293 Cells | Epigenesis, Genetic - drug effects | HSP90 Heat-Shock Proteins - genetics | Molecular Structure | Deferoxamine - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mitogen-Activated Protein Kinase 8 - metabolism | Ciprofloxacin - pharmacology | Deferoxamine - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Iron - metabolism | Dioxygenases - antagonists & inhibitors | Dioxygenases - genetics | Iron Chelating Agents - pharmacology | Methylation - drug effects | Epigenesis, Genetic - genetics | Fluoroquinolones - pharmacology | Ciprofloxacin - chemistry | HSP90 Heat-Shock Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Histones - metabolism | DNA Methylation - drug effects | Index Medicus | fluoroquinolone | collagen | dioxygenase | iron | Enzymology | epigenetics | antibiotic action
Journal Article