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The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2012, Volume 22, Issue 3, pp. 501 - 514
Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells... 
DEFECTS | TIP CELLS | ANGIOGENESIS | VEGF | ENDOTHELIAL-CELLS | ID PROTEINS | HES1 | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | EXPRESSION | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | Transcription Factor HES-1 | Humans | Intercellular Signaling Peptides and Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - metabolism | Inhibitor of Differentiation Proteins - biosynthesis | Inhibitor of Differentiation Protein 1 - biosynthesis | Serrate-Jagged Proteins | Smad5 Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Smad1 Protein - genetics | Membrane Proteins - metabolism | Smad5 Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - biosynthesis | Homeodomain Proteins - biosynthesis | Signal Transduction | Inhibitor of Differentiation Protein 2 - biosynthesis | Membrane Proteins - genetics | Down-Regulation | Cells, Cultured | Mice, Transgenic | Cell Cycle Proteins - biosynthesis | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Mice, Knockout | Membrane Proteins - biosynthesis | Phenotype | Animals | Smad1 Protein - metabolism | Mice | Neovascularization, Physiologic | Proteins | Endothelial growth factors | Genes | Genetic aspects | Transforming growth factors | Vascular endothelial growth factor | Endothelium | Index Medicus | Dll4 | tip cell | lateral inhibition | sprouting angiogenesis | BMP | directed migration | Notch | stalk cell | mouse embryo | Smad | polarity
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2251 - 2268
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants... 
Socs36E, suppressor of cytokine signaling at 36E | Vps25, vacuolar protein sorting 25 | dome | ESCRT, endosomal sorting complex required for transport | Syb, Synaptobrevin | hop-Stat92E, hopscotch-signal transducer and activator of transcription protein at 92E | SNARE | EM, electron microscopy | FE, follicular epithelium | usnp | CEDNIK, cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma | V-ATPase, vacuolar H | dome, domeless | NECD, N extracellular domain | Vamp, vesicle-associated membrane protein | trafficking | N, Notch | CFP, cyan fluorescent protein | Atg, autophagy-related | GFP, green fluorescent protein | autophagy | MENE, mutant eye no eclosion | ATPase | Notch | WT, wild type | refP, refractory to sigma P | MVB, multivesicular body | + | Snap29 | NPF, asparagine-proline-phenylalanine | SNARE, soluble NSF attachment protein receptor | os, outstretched | E(spl)mβ-HLH, enhancer of split mβ, helix-loop-helix | Syx, syntaxin | histone H3, His3 | Snap29, synaptosomal-associated protein 29 kDa | Dome | Trafficking | Usnp | Autophagy | ACTIVATION | FUSION | ATPASE | COMPLEX GENES | CELL BIOLOGY | GENETIC SCREEN | SNAP-29 | PATHWAY | NOTCH RECEPTOR | UNCONVENTIONAL SECRETION | MELANOGASTER | Exosomes - metabolism | Vesicular Transport Proteins - metabolism | Humans | Phagosomes - metabolism | Qb-SNARE Proteins - metabolism | Protein Transport - physiology | Autophagy - physiology | Drosophila Proteins - metabolism | Cell Movement - physiology | Endosomes - metabolism | Drosophila melanogaster - metabolism | Animals | Qc-SNARE Proteins - metabolism | SNARE Proteins - metabolism | Protein Binding - physiology | Index Medicus
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 11/2017, Volume 31, Issue 11, pp. 4720 - 4733
Before the onset of sprouting angiogenesis, the endothelium is prepatterned for the positioning of tip and stalk cells. Both cell identities are not static, as... 
cell migration | ALK2 | ALK3 | p38 MAPK | SMAD1/5 | MIGRATION | ACTIVATION | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | NOTCH | CANCER | ALK1 | CELL BIOLOGY | ENDOTHELIAL-CELLS | BIOLOGY | GROWTH-FACTOR | EXPRESSION | MAP Kinase Signaling System - physiology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | HSP27 Heat-Shock Proteins - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Protein 6 - genetics | Smad5 Protein - metabolism | Bone Morphogenetic Protein 2 - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Smad1 Protein - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Smad5 Protein - genetics | Bone Morphogenetic Protein 2 - genetics | Intercellular Signaling Peptides and Proteins - genetics | Bone Morphogenetic Protein Receptors, Type I - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Activin Receptors, Type I - metabolism | Bone Morphogenetic Protein Receptors, Type I - metabolism | Activin Receptors, Type I - genetics | Neovascularization, Physiologic - physiology | Bone Morphogenetic Protein 6 - metabolism | HSP27 Heat-Shock Proteins - metabolism | Smad1 Protein - metabolism | Complex formation | Genes | Clinical trials | Cell adhesion & migration | Proteins | Angiogenesis | Signal transduction | Receptors | Pathways | Bone morphogenetic proteins | Vascular endothelial growth factor | Protein-tyrosine kinase | Enhancer-of-split protein | Bone morphogenetic protein 6 | Tyrosine | Medical research | Bone morphogenetic protein 2 | Heat shock proteins | Gene expression | Spheroids | Endothelial cells | Bone morphogenetic protein receptor type I | Endothelium | Signaling | Antiangiogenics | Hsp27 protein | Bone | Activin | Cell migration | Heat shock | Index Medicus | SMAD1 | 5 | Research
Journal Article
Structure, ISSN 0969-2126, 01/2014, Volume 22, Issue 1, pp. 70 - 81
Notch refers to a highly conserved cell-to-cell signaling pathway with essential roles in embryonic development and tissue maintenance. Dysfunctional signaling... 
LIM PROTEIN | DOMAIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | BINDING-PROTEIN | EBNA2 | CELL-GROWTH | CELL BIOLOGY | BIOPHYSICS | DNA | CSL | RBP-J | Receptors, Notch - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | LIM Domain Proteins - metabolism | Thermodynamics | Escherichia coli - metabolism | Muscle Proteins - metabolism | Transcription, Genetic | Binding Sites | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | LIM Domain Proteins - chemistry | Immunoglobulin J Recombination Signal Sequence-Binding Protein - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Signal Transduction | Gene Expression Regulation | Cell Communication | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Muscle Proteins - genetics | Animals | Receptors, Notch - chemistry | Escherichia coli - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | LIM Domain Proteins - genetics | Mice | Muscle Proteins - chemistry | Mutation | Proteins | Embryonic development | Genetic transcription | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177516 - e0177516
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Index Medicus | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 278 - 285
The Notch signalling pathway has a crucial function in determining cell fates in multiple tissues within metazoan organisms. On binding to ligands, the Notch... 
COACTIVATOR | PROTEIN | DROSOPHILA MASTERMIND | PHOSPHORYLATION | PATHWAY | HOMOLOG | DIFFERENTIATION | NLK | RECEPTORS | EXPRESSION | CELL BIOLOGY | Phosphorylation - physiology | Xenopus | RNA, Small Interfering - genetics | ELAV-Like Protein 3 | Transcription Factor HES-1 | Protein Interaction Domains and Motifs - physiology | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nuclear Proteins - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Zebrafish Proteins - metabolism | ELAV Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation - physiology | Nuclear Proteins - metabolism | Zebrafish | DNA - metabolism | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Oligonucleotides, Antisense - genetics | Amino Acid Substitution - physiology | Models, Biological | Neurogenesis - physiology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Zebrafish Proteins - genetics | Receptor, Notch1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Protein Binding - physiology | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Genetic transcription | Protein kinases | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 5, pp. 912 - 924
Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. This ubiquitination step... 
SYSTEM | MORPHOGENESIS | PROTEIN | UBIQUITIN LIGASE | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIFFERENTIATION | ENDOCYTOSIS | SERRATE | INTRACELLULAR MOTIFS | DROSOPHILA | CELL BIOLOGY | Wnt1 Protein | Epitopes - metabolism | Receptors, Notch - metabolism | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Serrate-Jagged Proteins | HEK293 Cells | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Drosophila Proteins - chemistry | Epitopes - genetics | Ubiquitin-Protein Ligases - chemistry | Blotting, Western | Sequence Homology, Amino Acid | Animals | Membrane Proteins - chemistry | Receptors, Notch - chemistry | Cell Line, Tumor | Protein Binding | Ligands | Epitopes - chemistry | Drosophila Proteins - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Calcium-Binding Proteins - genetics | Ubiquitin | Cellular signal transduction | Ligases | Antigenic determinants | Structure | Crystals | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e60244 - e60244
Endocardial to mesenchymal transformation (EMT) is a fundamental cellular process required for heart valve formation. Notch, Wnt and Bmp pathways are known to... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSFORMATION | DEVELOPING CHICKEN HEART | MORPHOGENESIS | CUSHION | CELLS | NF-ATC | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTOR | TRANSCRIPTION FACTOR | CARDIAC DEVELOPMENT | Wnt4 Protein - metabolism | Embryo, Mammalian | Heart Valves - metabolism | Epithelial-Mesenchymal Transition - genetics | Endocardium - metabolism | Wnt4 Protein - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Gene Expression Regulation, Developmental | Serrate-Jagged Proteins | Bone Morphogenetic Protein 2 - metabolism | Myocardium - metabolism | Membrane Proteins - metabolism | Heart Valves - embryology | Extracellular Matrix Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Bone Morphogenetic Protein 2 - genetics | Signal Transduction | Endocardium - embryology | Membrane Proteins - genetics | Extracellular Matrix Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Receptor, Notch1 - metabolism | Animals | Organogenesis - genetics | Mice | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Cellular signal transduction | Research | Wnt proteins | Heart valves | Heart | Transformation | Wnt protein | Mesenchyme | Laboratories | Paracrine signalling | Defects | Morphogenesis | Signal transduction | Cell growth | Pathways | Rodents | Bone morphogenetic proteins | Jagged1 protein | Cardiology | Immunoglobulins | Bone morphogenetic protein 2 | Cultures | Histology | Ribonucleic acid--RNA | Embryos | Medicine | Hospitals | Myocardium | Notch protein | Index Medicus | RNA | Ribonucleic acid
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2010, Volume 18, Issue 2, pp. 288 - 299
Journal Article