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cell differentiation (99) 99
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cancer (91) 91
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cell line, tumor (89) 89
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research (86) 86
receptor, notch1 (83) 83
gene (82) 82
jagged-1 protein (82) 82
apoptosis (79) 79
biochemistry & molecular biology (78) 78
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pathway (76) 76
developmental biology (75) 75
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middle aged (73) 73
genetic aspects (72) 72
receptors, notch - metabolism (72) 72
genes (69) 69
mutations (68) 68
proteins (68) 68
growth (66) 66
analysis (65) 65
immunohistochemistry (63) 63
proliferation (62) 62
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immunology (59) 59
mice, knockout (59) 59
receptor, notch4 (59) 59
genetics & heredity (57) 57
receptor, notch3 (57) 57
receptors, notch - genetics (57) 57
adult (56) 56
cells (56) 56
hematology (55) 55
mice, transgenic (55) 55
endocrine system (54) 54
transcription factor hes-1 (54) 54
gene expression regulation, neoplastic (53) 53
signal transduction - physiology (53) 53
stem cells (53) 53
receptors, cell surface - metabolism (52) 52
gene expression regulation, developmental (50) 50
intercellular signaling peptides and proteins - genetics (50) 50
reverse transcriptase polymerase chain reaction (50) 50
in-vivo (49) 49
intercellular signaling peptides and proteins - metabolism (49) 49
homeodomain proteins - metabolism (48) 48
medicine, research & experimental (47) 47
multidisciplinary sciences (47) 47
cell line (46) 46
homeodomain proteins - genetics (46) 46
pathology (46) 46
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signaling pathway (46) 46
receptors, notch (45) 45
mouse (44) 44
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aged (43) 43
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alagille-syndrome (42) 42
signal transduction - genetics (42) 42
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tumors (42) 42
abridged index medicus (41) 41
proto-oncogene proteins - genetics (41) 41
rna, messenger - metabolism (41) 41
base sequence (40) 40
basic helix-loop-helix transcription factors - metabolism (40) 40
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Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 59, Issue 1, pp. 124 - 130
Background & Aims Repair from biliary damages requires the biliary specification of hepatic progenitor cells and the remodeling of ductular reactive structures... 
Gastroenterology and Hepatology | Liver repair | Ductular reaction | GSI | Alagille syndrome | Notch signaling | Cholangiocytes | SECRETASE | CELLS | INTRAHEPATIC BILE-DUCTS | PROLIFERATION | INHIBITION | ALAGILLE-SYNDROME | GENE | LIVER | MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | REVEALS | RNA, Small Interfering - genetics | Calcium-Binding Proteins - antagonists & inhibitors | Receptor, Notch2 - genetics | Bile Ducts, Intrahepatic - physiopathology | Intercellular Signaling Peptides and Proteins - physiology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - physiology | Membrane Proteins - physiology | Serrate-Jagged Proteins | 1-Naphthylisothiocyanate - toxicity | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | Bile Ducts, Intrahepatic - pathology | Membrane Proteins - genetics | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - deficiency | Liver Regeneration - physiology | Receptor, Notch2 - deficiency | Mice, Knockout | Receptor, Notch2 - physiology | Animals | Bile Ducts, Intrahepatic - injuries | Membrane Proteins - antagonists & inhibitors | Pyridines - toxicity | Signal Transduction - drug effects | Calcium-Binding Proteins - physiology | Morphogenesis - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Stem Cells - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Morphogenesis - physiology | Calcium-Binding Proteins - genetics | Liver Regeneration - drug effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1875 - 1880
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development.... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | skeletal development | BONE-DEVELOPMENT | LIGANDS | ARTICULAR-CARTILAGE | PATHWAY | GROWTH | cartilage degradation | DIFFERENTIATION | RECEPTORS | EXPRESSION | REVEALS | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Biological Sciences
Journal Article
Development, ISSN 0950-1991, 11/2006, Volume 133, Issue 21, pp. 4381 - 4390
Mutations in Notch2, Jagged1 or homologs of the Hairy-related transcriptional repressor Hey2 cause congenital malformations involving the non-chamber... 
Atrioventricular canal | HES | Notch | T-box | Gridlock | HRT | Tbx | Hairy-related transcription factor | HEY | HEY GENES | MOUSE EMBRYOGENESIS | MAMMALIAN NOTCH | DEVELOPMENTAL BIOLOGY | atrioventricular canal | gridlock | CARDIOVASCULAR DEVELOPMENT | ALAGILLE-SYNDROME | SIGNALING PATHWAY | SEGMENTATION CLOCK | Hey | PRESOMITIC MESODERM | CHAMBER FORMATION | EMBRYONIC CHICK HEART | Heart - anatomy & histology | Heart - embryology | Heart - physiology | Receptor, Notch2 - genetics | Morphogenesis | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Serrate-Jagged Proteins | Myocardium - metabolism | Membrane Proteins - metabolism | Chick Embryo - anatomy & histology | Bone Morphogenetic Proteins - genetics | Repressor Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Chick Embryo - physiology | Bone Morphogenetic Protein 2 | Membrane Proteins - genetics | Heart - growth & development | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Zebrafish Proteins | Repressor Proteins - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Myocardium - cytology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Transforming Growth Factor beta - genetics | Signal Transduction - physiology | Mice | Transforming Growth Factor beta - metabolism | Calcium-Binding Proteins - genetics
Journal Article
Leukemia, ISSN 0887-6924, 05/2015, Volume 29, Issue 5, pp. 1177 - 1185
To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent... 
B-CELL DEVELOPMENT | NOTCH2 | ACTIVATION | ONCOLOGY | INFLAMMATION | GENES | IMMUNOGLOBULIN | RECEPTOR | KRUPPEL-LIKE FACTOR-2 | HEMATOLOGY | EXPRESSION | DELETION | Recurrence | Frameshift Mutation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | DNA-Binding Proteins - metabolism | Exome | Genetic Variation | Lymphoma - metabolism | CARD Signaling Adaptor Proteins - metabolism | Polymerase Chain Reaction | Tumor Necrosis Factor alpha-Induced Protein 3 | Signal Transduction | Splenic Neoplasms - genetics | Receptor, Notch2 - metabolism | Genotype | Guanylate Cyclase - metabolism | Nuclear Proteins - metabolism | Splenic Neoplasms - diagnosis | Sequence Analysis, DNA | Lymphoma, B-Cell, Marginal Zone - genetics | Lymphoma, B-Cell, Marginal Zone - diagnosis | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Biopsy | Mutation | Kruppel-Like Transcription Factors - genetics | Care and treatment | Usage | Lymphomas | B cells | Research | Medical screening | Health aspects | Tumor necrosis factor receptors | Deregulation | p53 Protein | Hyperplasia | Frameshift mutation | Gene deletion | Signal transduction | Missense mutation | Clonal deletion | Genetics | Zinc finger proteins | Genotypes | Kruppel protein | Spleen | NF-κB protein | Lymphoma | Zinc | Domains | Signaling | Lymphocytes B | MyD88 protein | Lung Kruppel-like factor | B-cell lymphoma
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2015, Volume 28, Issue 6, pp. 730 - 742
In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an... 
brain tumor | glioma | Notch signaling | Hes5 | primitive neuroectodermal tumor | Brain tumor | Glioma | Primitive neuroectodermal tumor | SURVIVAL | NEURAL STEM-CELLS | GLIOBLASTOMA | ONCOLOGY | GLIOMA | GROWTH | GENOMIC ANALYSIS | SELF-RENEWAL | NUCLEAR RECEPTOR TAILLESS | EXPRESSION | BRAIN-TUMORS | CELL BIOLOGY | Cell Proliferation | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Expression Profiling | Glioma - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Time Factors | Glioma - pathology | Neoplastic Stem Cells - pathology | Brain Neoplasms - mortality | Prosencephalon - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Repressor Proteins - metabolism | Gene Transfer Techniques | Tumor Suppressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Glioma - mortality | Signal Transduction | Brain Neoplasms - genetics | Repressor Proteins - genetics | Tumor Burden | Mice, Knockout | Phenotype | Infusions, Intraventricular | Receptor, Notch1 - genetics | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Databases, Genetic | Receptor, Notch2 - genetics | Platelet-Derived Growth Factor - administration & dosage | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Glioma - metabolism | Neoplasm Grading | Tumor Suppressor Proteins - genetics | Prosencephalon - pathology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Kaplan-Meier Estimate | Receptor, Notch2 - metabolism | Tumor Suppressor Protein p53 - metabolism | Receptor, Notch1 - metabolism | Neural Stem Cells - pathology | Recombinant Proteins - administration & dosage | Animals | Neural Stem Cells - metabolism | Brain | Platelet-derived growth factor | Tumor proteins | Gliomas | Analysis | Stem cells | Brain tumors | Cancer
Journal Article
Development (Cambridge), ISSN 0950-1991, 01/2014, Volume 141, Issue 2, pp. 318 - 324
The skin pigment pattern of zebrafish is a good model system in which to study the mechanism of biological pattern formation. Although it is known that... 
Turing mechanism | Pigment pattern | Delta/Notch signal | DANIO-RERIO | MUTANT | PROTEIN | ORTHOLOGUE | DEVELOPMENTAL BIOLOGY | CELL DEVELOPMENT | LEOPARD | SUBPOPULATION | IN-VIVO | KIT | MELANOCYTES | Delta | Notch signal
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 184 - 198
The Notch pathway is a highly conserved juxtacrine signaling mechanism that is important for many cellular processes during development, including... 
LIGAND ENDOCYTOSIS | ACTIVATION | INNER-EAR | LATERAL INDUCTION | CYCLIN D2 | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FOLLICLE-STIMULATING-HORMONE | OOCYTE CYST BREAKDOWN | CORPUS-LUTEUM | Jagged-1 Protein - metabolism | Receptor, Notch2 - agonists | Receptor, Notch2 - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Chorionic Gonadotropin - pharmacology | RNA Interference | Jagged-1 Protein - antagonists & inhibitors | Female | Receptor, Notch3 - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Estradiol - metabolism | Green Fluorescent Proteins - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Receptor, Notch3 - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - antagonists & inhibitors | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Receptor, Notch2 - metabolism | Mice, Transgenic | Mice, Inbred Strains | Jagged-1 Protein - genetics | Gonadotropins, Equine - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Progesterone - metabolism | Recombinant Fusion Proteins - genetics | Genes, Reporter - drug effects | Receptor, Notch3 - agonists | Cell Proliferation - drug effects | Granulosa Cells - cytology | Cell proliferation | Menopause | Differentiation (biology) | Intracellular signalling | AKT protein | Biosynthesis | Kinases | Oocytes | Proteins | Signal transduction | Receptors | Cell activation | Developmental stages | Granulosa cells | Luteinizing hormone | Gametocytes | Localization | Phenotypes | Secretion | Extracellular signal-regulated kinase | MAP kinase | Pituitary (anterior) | Gonadotropins | siRNA | Cell differentiation | 1-Phosphatidylinositol 3-kinase | Signaling | Somatic cells | Ligands | Steroidogenesis | Steroids
Journal Article
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2010, Volume 88, Issue 2, pp. 279 - 290
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2016, Volume 6, Issue 1, p. 23972
The size of the primordial follicle pool determines the reproductive potential of mammalian females, and establishment of the pool is highly dependent on... 
POLYOVULAR FOLLICLES | STAT3 ACTIVATION | EMBRYO IMPLANTATION | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | RHO GTPASES | RAS TRANSFORMATION | MAXIMAL ACTIVATION | FOLLICULAR-GROWTH | MOUSE OVARIES | SERINE PHOSPHORYLATION | Immunohistochemistry | Jagged-1 Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes - genetics | Receptor, Notch2 - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ovarian Follicle - drug effects | Cell Nucleus - metabolism | TOR Serine-Threonine Kinases - genetics | RNA Interference | Gene Expression Regulation, Developmental | Bone Morphogenetic Protein 15 - genetics | Female | Transcription, Genetic | Active Transport, Cell Nucleus - genetics | Aminoquinolines - pharmacology | Growth Differentiation Factor 9 - genetics | Ovarian Follicle - metabolism | Organ Culture Techniques | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Receptor, Notch2 - metabolism | Bone Morphogenetic Protein 15 - metabolism | Ovarian Follicle - embryology | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Jagged-1 Protein - genetics | Animals | Growth Differentiation Factor 9 - metabolism | rac1 GTP-Binding Protein - antagonists & inhibitors | Protein Binding | Mice | Models, Genetic | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Cell culture | Molecular modelling | Transcription | Cysts | Fetuses | Organ culture | Stat3 protein | Rac1 protein | Jagged1 protein | Follicles | Nuclear transport | Guanosinetriphosphatase
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2017, Volume 36, Issue 15, pp. 2204 - 2215
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 11/2018, Volume 25, Issue 10, pp. 1837 - 1854
Zika virus (ZV) infects neural stem cells (NSCs) and causes quiescence in NSCs, reducing the pool of brain cells, leading to microcephaly. Despite... 
PROGENITOR CELLS | NOTCH2 | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROGENESIS | PROLIFERATION | INFECTION | DIFFERENTIATION | PRECURSOR CELLS | BRAIN | CELL BIOLOGY | Up-Regulation | MicroRNAs - antagonists & inhibitors | Humans | MicroRNAs - metabolism | Receptor, Notch2 - genetics | Gene Regulatory Networks | Neural Stem Cells - cytology | Viral Envelope Proteins - metabolism | G1 Phase Cell Cycle Checkpoints | Cell Differentiation | 3' Untranslated Regions | Zika Virus - metabolism | Viral Envelope Proteins - genetics | Signal Transduction | Cell Survival | Down-Regulation | Neural Stem Cells - virology | Receptor, Notch2 - metabolism | Genetic Vectors - metabolism | Genetic Vectors - genetics | Fetus - cytology | Viral Nonstructural Proteins - metabolism | Receptor, Notch2 - chemistry | Antagomirs - metabolism | MicroRNAs - chemistry | Neural Stem Cells - metabolism | Apoptosis | Platelet-derived growth factor | Wnt protein | p53 Protein | Stem cell transplantation | Zika virus | Subventricular zone | Proteins | Epidermal growth factor | Cell cycle | Neurospheres | miRNA | Pax3 protein | G1 phase | Structural proteins | Fetuses | Envelope protein | Electroporation | Microencephaly | Molecular modelling | 3' Untranslated regions | MicroRNAs | Stem cells | Neural stem cells | Ventricle | Cell migration | Cell biology | Neuroscience
Journal Article