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NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 03/2010, Volume 362, Issue 12, pp. 1102 - 1109
We describe two siblings from a consanguineous family with autosomal recessive Fanconi's syndrome and hypophosphatemic rickets. Genetic analysis revealed a... 
NEPHROLITHIASIS | SLC34A3 | HYPERCALCIURIA | NPT2A | MEDICINE, GENERAL & INTERNAL | HEREDITARY HYPOPHOSPHATEMIC RICKETS | HOMEOSTASIS | METABOLISM | MICE | ALBUMIN | SODIUM-PHOSPHATE COTRANSPORTER
Journal Article
The Journal of Medical Investigation, ISSN 1343-1420, 2013, Volume 60, Issue 3.4, pp. 191 - 196
The type IIa sodium-dependent phosphate co-transporter (Npt2a) is important to maintain renal inorganic phosphate (Pi) homeostasis and the plasma Pi levels. It... 
cholesterol | hyperlipidemia | hypophosphatemia | mice | Npt2a | Hypophosphatemia | Mice | Hyperlipidemia | Cholesterol
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 11/2018, Volume 315, Issue 5, pp. F1261 - F1270
Phosphate homeostasis is primarily maintained in the renal proximal tubules, where the expression of sodium/phosphate cotransporters (Npt2a and Npt2c) is... 
1,25(OH) | Parathyroid hormone | Renal Npt2a | Mineral metabolism | parathyroid hormone | renal Npt2a | KLOTHO | PHYSIOLOGY | PTH | VASCULAR CALCIFICATION | 1,25(OH)D-3 | HYPOPHOSPHATEMIA | mineral metabolism | PARATHYROID-HORMONE RECEPTOR | MESSENGER-RNA | CA2+ TRANSPORT | CALCIUM | UROLOGY & NEPHROLOGY | FIBROBLAST GROWTH FACTOR-23 | KIDNEY | 1,25(OH)2D3
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 05/2018, Volume 93, Issue 5, pp. 1073 - 1085
Circulating inorganic phosphate exhibits a remarkable daily oscillation based on food intake. In humans and rodents, the daily oscillation in response to food... 
NAD | phosphate | daily oscillation | Npt2c | Nampt | Npt2a | CIRCADIAN-RHYTHM | SERUM PHOSPHATE | CARDIOVASCULAR-DISEASE | HEMODIALYSIS-PATIENTS | ADENINE-DINUCLEOTIDE | UROLOGY & NEPHROLOGY | PARATHYROID-HORMONE | DIETARY PHOSPHATE | DIURNAL-VARIATION | CHRONIC KIDNEY-DISEASE | STAGE RENAL-DISEASE | Biomarkers - urine | Liver - enzymology | Sodium-Phosphate Cotransporter Proteins, Type IIb - genetics | Kidney - enzymology | Male | Mice, 129 Strain | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Sodium-Phosphate Cotransporter Proteins, Type IIb - metabolism | Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism | Nicotinamide Phosphoribosyltransferase - metabolism | Time Factors | Sodium-Phosphate Cotransporter Proteins, Type IIc - genetics | Sodium-Phosphate Cotransporter Proteins, Type IIc - metabolism | Phosphates - urine | Phosphates - blood | Female | Cytokines - genetics | NAD - metabolism | Cytokines - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Biomarkers - blood | Nicotinamide Phosphoribosyltransferase - deficiency | Circadian Rhythm | Sodium-Phosphate Cotransporter Proteins, Type IIc - deficiency | Renal Elimination | Sodium-Phosphate Cotransporter Proteins, Type IIa - genetics | Nicotinamide Phosphoribosyltransferase - genetics | Animals | Sodium-Phosphate Cotransporter Proteins, Type IIb - deficiency | Sodium-Phosphate Cotransporter Proteins, Type IIa - deficiency | Cytokines - deficiency | Cytokines - antagonists & inhibitors | Intestines - enzymology | NADPH | Plasma | Renal function | Homeostasis | Proteins | Sodium phosphate | Clonal deletion | Intestine | Phosphate | Rodents | Light | Phosphoribosyltransferase | Intestinal absorption | Food | Excretion | Kidneys | Mortality | Reabsorption | Metabolism | Sodium | Hepatocytes | Food intake | Nicotinamide phosphoribosyltransferase | Nicotinamide | Kidney diseases
Journal Article
by Wu, HZ and Mao, CH and Duenstl, G and Su, W and Qian, S
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 12/2013, Volume 721, Issue 1-3, pp. 332 - 340
Hyperphosphatemia is associated with severe decline of renal function in chronic kidney disease and elevates cardiovascular mortality. Type II sodium dependent... 
PHOSPHONOFORMIC ACID | SLC34A1 | INORGANIC-PHOSPHATE | Assay development | MECHANISMS | FAMILY | HYPERCALCIURIA | CLONING | Specific inhibitor | Hyperphosphatemia | COTRANSPORTER | PHARMACOLOGY & PHARMACY | PROTEINS | REABSORPTION | EXPRESSION | Npt2A | Phosphate uptake
Journal Article
JOURNAL OF THE ROYAL SOCIETY INTERFACE, ISSN 1742-5689, 01/2013, Volume 10, Issue 78
The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by... 
NPT2A | PROXIMAL TUBULE CELLS | PTH | MULTIDISCIPLINARY SCIENCES | DOPAMINE | PARATHYROID-HORMONE | FACTOR-I | EXCHANGER
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 36, pp. 18632 - 18642
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to... 
RENAL PROXIMAL TUBULE | PROTEIN-KINASE-A | MDCK CELLS | ACTIVATION | PTH | FGF-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | I COTRANSPORTERS | FACTOR RECEPTOR GENES | CALCIUM-TRANSPORT | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 4 - biosynthesis | Parathyroid Hormone - genetics | Sodium-Hydrogen Exchangers - metabolism | Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism | Sodium-Phosphate Cotransporter Proteins, Type IIa - genetics | Fibroblast Growth Factors - metabolism | Phosphates - metabolism | Glucuronidase - biosynthesis | Glucuronidase - genetics | Parathyroid Hormone - metabolism | Receptor, Parathyroid Hormone, Type 1 - genetics | Signal Transduction - physiology | Sodium-Hydrogen Exchangers - genetics | Receptor, Fibroblast Growth Factor, Type 3 - biosynthesis | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Cell Line, Transformed | parathyroid hormone | NPT2A | klotho | PDZ Protein | fibroblast growth factor receptor (FGFR) | NHERF1 | alternative splicing | G protein-coupled receptor (GPCR) | transport | Cell Biology
Journal Article
The Journal of urology, ISSN 0022-5347, 9/2010, Volume 184, Issue 3, pp. 1189 - 1196
Journal Article