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heme oxygenase-1 (29) 29
nadh (29) 29
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genetic predisposition to disease (26) 26
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free radicals (25) 25
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Journal Article
Tuberculosis and Respiratory Diseases, ISSN 1738-3536, 2016, Volume 79, Issue 4, p. 257
Background: Idiopathic pulmonary fibrosis is a common interstitial lung disease; it is a chronic, progressive, and fatal lung disease of unknown etiology. Over... 
Human | Inflammation; Fibrosis; Transforming Growth Factor Beta1; Cell; NAD; Pulmonary Fibrosis; Mice; NQO1 Protein
Journal Article
Journal Article
Environmental Toxicology, ISSN 1520-4081, 05/2019, Volume 34, Issue 5, pp. 645 - 651
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2008, Volume 231, Issue 3, pp. 364 - 373
The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage.... 
2,6-dichlorophenolindophenol | Oxidative stress | glutathione-S-transferase | DCPIP | HO-1 | Mrp | glutamate cysteine ligase catalytic subunit | relative light units | Kidney | 4-HNE | Multidrug resistance-associated protein | Nrf2 | 1-[2-cyano-3-,12-dioxooleana-1,9-dien-28-oyl]imidazole | NF-E2-related factor 2 | RLU | branched DNA signal amplification | ferric nitrilotriacetate | NQO1 | Kelch-like ECH-associated protein 1 | CDDO-Im | GST | heme oxygenase-1 | NAD(P)H:quinone oxidoreductase 1 | 4-hydroxynonenal | GCLC | FeNTA | bDNA | Keap1 | FERRIC NITRILOTRIACETATE | PROXIMAL TUBULES | HEME OXYGENASE-1 GENE | RESISTANCE-ASSOCIATED PROTEINS | kidney | TRANSCRIPTION FACTOR NRF2 | INDUCED RENAL CARCINOGENESIS | NF-E2-RELATED FACTOR-2 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CDDO-IMIDAZOLIDE | BINDING-SITES | oxidative stress | Ferric Compounds - toxicity | Kidney Diseases - prevention & control | Mice, Inbred C57BL | Oxidative Stress - physiology | Gene Expression Regulation - physiology | Male | Nitrilotriacetic Acid - toxicity | Nitrilotriacetic Acid - analogs & derivatives | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Kidney Diseases - chemically induced | NF-E2-Related Factor 2 - genetics | Mice | Oxidative Stress - drug effects | NF-E2-Related Factor 2 - biosynthesis | Kidney Diseases - metabolism | Gene expression | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | TUBULES | CYSTEINE | IRON | TOXICITY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | ECR HEATING | HEME | GLUTATHIONE | CARCINOMAS | CREATININE | LIGASES | MICE | OXYGENASES | UREA
Journal Article
Toxicology Letters, ISSN 0378-4274, 01/2016, Volume 243, pp. 22 - 30
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2004, Volume 377, Issue 1, pp. 205 - 213
TCDD (2,3,7,8-tetrachlorodibenzo-p-dixoin) induces phase II drug-metabolizing enzyme NQO1 [NAD(P)H:quinone oxidoreductase; EC 1.6.99.2; DT-diaphorase] in a... 
AhR (aryl hydrocarbon receptor) | DRE (dioxin response element) | TCDD (2,3,7,8-tetrachlorodibenzo-p- dioxin) | ARE (antioxidant response element) | NQO1 [NAD(P)H:quinone oxidoreductase 1] | Nrf2 (nuclear factor erythroid 2-related factor 2) | NQO1 [NAD(P)H : quinone oxidoreductase 1] | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | POLYMORPHISM | IDENTIFICATION | ANTIOXIDANT RESPONSE ELEMENT | CARCINOGENESIS | DT-DIAPHORASE | NQO1 GENE | GENE-EXPRESSION | TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) | UBIQUITIN-PROTEASOME PATHWAY | INDUCIBLE EXPRESSION | Leucine Zippers | Multienzyme Complexes - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Proteasome Endopeptidase Complex | Trans-Activators - chemistry | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Transcription, Genetic | Protein Synthesis Inhibitors - pharmacology | Ubiquitins - metabolism | DNA-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | Enzyme Induction | Antioxidants - pharmacology | DNA-Binding Proteins - chemistry | Cycloheximide - pharmacology | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Ligands | NF-E2-Related Factor 2 | Trans-Activators - metabolism | Mice | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2003, Volume 374, Issue 2, pp. 337 - 348
Journal Article
Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 40, pp. 4362 - 4371
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 202 - 212
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules... 
Brusatol | Free radicals | Hepatocyte | Nrf2 | Toxicity | Keap1 | Chemical stress | Cell defense | OXIDATIVE STRESS | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS INHIBITION | CANCER | TRANSCRIPTION FACTOR NRF2 | DEFENSE PATHWAY | ACETAMINOPHEN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Oxidative Stress | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | Autophagy | Quassins - pharmacology | Hepatocytes - cytology | Carcinoma, Hepatocellular - drug therapy | Liver Neoplasms - pathology | NF-E2-Related Factor 2 - genetics | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Brucea - chemistry | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Chemical inhibitors | Metabolites | Proteolysis | Health aspects | Quinone | Cells | Index Medicus | Gclm, glutamate–cysteine ligase regulatory subunit | NEM, N-ethylmaleimide | NAPQI, N-acetyl-p-benzoquinone imine | IAA, iodoacetamide | Nrf2, nuclear factor erythroid 2-related factor 2 | Original Contribution | Keap1, Kelch-like ECH-associated protein 1 | DNCB, 2,4-dinitrochlorobenzene | Nqo1, NAD(P)H dehydrogenase quinone 1 | CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9dien-28-oate | HIF-1α, hypoxia-inducible factor 1α | RT-qPCR, real-time quantitative PCR | AMC, 7-amino-4-methylcoumarin
Journal Article
Mediators of Inflammation, ISSN 0962-9351, 2017, Volume 2017, pp. 4139439 - 9
Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used antihyperglycemic agents for the treatment of type 2 diabetes mellitus. Recently, the pleiotropic... 
ACUTE KIDNEY INJURY | NQO1 | NRF2 | THERAPEUTIC TARGET | SITAGLIPTIN | MECHANISMS | THERAPIES | HEME OXYGENASE-1 | IMMUNOLOGY | RENAL INJURY | EXPRESSION | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Dipeptidyl Peptidase 4 - metabolism | Heme Oxygenase-1 - metabolism | Kidney - drug effects | Glucagon-Like Peptide 1 - metabolism | Kidney - pathology | Apoptosis - drug effects | Mice, Inbred C57BL | Male | Pyrimidines - pharmacology | Piperidones - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Animals | Cisplatin - toxicity | Transcription Factor RelA - metabolism | Protective Agents - pharmacology | Inflammation Mediators - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Chemokine CCL2 - metabolism | Membrane Proteins - metabolism | Mice | Cisplatin - antagonists & inhibitors | Kidney - physiopathology | Measurement | Physiological aspects | Kidney diseases | Drug therapy | Health aspects | Cisplatin | Blood plasma | Plasma | Quinone oxidoreductase | Nephrology | Renal function | Glucagon | Oxidoreductase | Rodents | Heme | Tumor necrosis factor-TNF | Physiology | Drug dosages | Diabetes mellitus (non-insulin dependent) | Glucagon-like peptide 1 | Creatinine | Kidneys | Peptidase | Quinone | Diabetes mellitus | Heme oxygenase (decyclizing) | Inflammation | Tumor necrosis factor-α | NAD(P)H:quinone oxidoreductase | DNA nucleotidylexotransferase | NAD | Oxygenase | Monocytes | Cell death | Monocyte chemoattractant protein | Plasma levels | Diabetes | Laboratory animals | Monocyte chemoattractant protein 1 | Apoptosis | Index Medicus
Journal Article
Journal Article
In Vitro Cellular & Developmental Biology. Animal, ISSN 1071-2690, 7/2009, Volume 45, Issue 7, pp. 388 - 397
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 41, pp. 15091 - 15096
DJ-1/PARK7, a cancer- and Parkinson's disease (PD)-associated protein, protects cells from toxic stresses. However, the functional basis of this protection has... 
Antioxidants | Oxidative stress | Enzymes | Messenger RNA | RNA | Protein synthesis | Genes | Cell lines | Small interfering RNA | Liver cells | Keap1 | NQO1 | PARK7 | Neurodegeneration | ELEMENT-MEDIATED EXPRESSION | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | neurodegeneration | DETOXIFYING ENZYME GENES | INDUCTION | CELL-DEATH | RESPONSE ELEMENT | CUL3-BASED E3 LIGASE | DT-DIAPHORASE | PATHWAY | oxidative stress | Oncogene Proteins - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Embryo, Mammalian | Fibroblasts - physiology | Antioxidants - metabolism | Humans | Neoplasm Proteins - physiology | Ubiquitin - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Oncogene Proteins - physiology | Parkinson Disease - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Fibroblasts - chemistry | Mice, Inbred C57BL | Mice, Knockout | Peroxiredoxins | Protein Deglycase DJ-1 | Animals | Antioxidants - physiology | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Mice | Intracellular Signaling Peptides and Proteins - physiology | Parkinson Disease - etiology | Parkinson's disease | Genetic aspects | Research | Genetic regulation | Structure | Cancer | Proteins | Studies | Parkinsons disease | Index Medicus | Biological Sciences
Journal Article