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1. Full Text Autophagy mediates degradation of nuclear lamina
by Dou, Zhixun and Xu, Caiyue and Donahue, Greg and Shimi, Takeshi and Pan, Ji-An and Zhu, Jiajun and Ivanov, Andrejs and Capell, Brian C and Drake, Adam M and Shah, Parisha P and Catanzaro, Joseph M and Ricketts, M. Daniel and Lamark, Trond and Adam, Stephen A and Marmorstein, Ronen and Zong, Wei-Xing and Johansen, Terje and Goldman, Robert D and Adams, Peter D and Berger, Shelley L
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7576, pp. 105 - 109
Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is... 
ORGANIZATION | CHROMATIN | MULTIDISCIPLINARY SCIENCES | DISEASE | SENESCENCE | PROTEINS | SELECTIVE AUTOPHAGY | EXPRESSION | DOMAINS | P53 | Chromatin - metabolism | Lamin Type B - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cells, Cultured | Cytoplasm - metabolism | Autophagy | Lamin Type B - metabolism | Oncogene Protein p21(ras) - metabolism | Autophagy-Related Protein 8 Family | Animals | Lysosomes - metabolism | Nuclear Lamina - metabolism | Cell Transformation, Neoplastic | Cellular Senescence | Proteolysis | HEK293 Cells | Fibroblasts | Protein Binding | Mice | Microfilament Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Chromatin - chemistry | Autophagy (Cytology) | Cellular proteins | Genetic aspects | Disease susceptibility | Properties | Health aspects | Carcinogenesis | Proteins | Studies | Cell growth | Senescence | Peptides | Gene expression
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2. Full Text Single-Cell Dynamics of Genome-Nuclear Lamina Interactions
by Kind, Jop and Pagie, Ludo and Ortabozkoyun, Havva and Boyle, Shelagh and de Vries, Sandra S and Janssen, Hans and Amendola, Mario and Nolen, Leisha D and Bickmore, Wendy A and van Steensel, Bas
Cell, ISSN 0092-8674, 03/2013, Volume 153, Issue 1, pp. 178 - 192
The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina associated domains (LADs). The dynamics of these interactions and the... 
MITOSIS | METHYLATION | POSITIONS | HISTONE H3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETEROCHROMATIN | GENES | CHROMATIN DYNAMICS | EARLY G1 | DOMAINS | G9A | CELL BIOLOGY | Mitosis | Humans | Gene Expression Regulation | DNA Methylation | Heterochromatin - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Nuclear Lamina - metabolism | Single-Cell Analysis - methods | Nuclear Lamina - chemistry | Cell Line, Tumor | Chromosomes - metabolism | Adenine - metabolism | Genome | Histocompatibility Antigens - metabolism | Chromosomes | Transferases | Genomics
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3. Full Text Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
by Brasset, Emilie and Wessels, Lodewyk and Faza, Marius B and Meuleman, Wouter and de Klein, Annelies and Eussen, Bert H and de Laat, Wouter and van Steensel, Bas and Talhout, Wendy and Guelen, Lars and Pagie, Ludo
Nature, ISSN 0028-0836, 06/2008, Volume 453, Issue 7197, pp. 948 - 951
The architecture of human chromosomes in interphase nuclei is still largely unknown. Microscopy studies have indicated that specific regions of chromosomes are... 
CELLS | LOCALIZATION | HUMAN GENOME | PERIPHERY | EMERIN | MULTIDISCIPLINARY SCIENCES | MEMBRANE PROTEIN | TRANSCRIPTION | GENE-EXPRESSION | ARCHITECTURE | MECHANISMS | Chromosome Positioning | Cell Line | Chromatin - metabolism | Chromosomes, Human - genetics | Humans | Chromosomes, Human - metabolism | Promoter Regions, Genetic - genetics | Lamin Type B - metabolism | DNA-Binding Proteins - metabolism | Nuclear Lamina - metabolism | CCCTC-Binding Factor | Nuclear Lamina - chemistry | CpG Islands - genetics | Fibroblasts | Protein Binding | Genome, Human | Chromatin - genetics | Repressor Proteins - metabolism | Research | Chemical properties | Human chromosomes | Cell nuclei | Genetics | Chromosomes | Genomics | Fluorescence in situ hybridization
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4. Full Text Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence
by Meuleman, Wouter and Peric-Hupkes, Daan and Kind, Jop and Beaudry, Jean-Bernard and Pagie, Ludo and Kellis, Manolis and Reinders, Marcel and Wessels, Lodewyk and Van Steensel, Bas
Genome Research, ISSN 1088-9051, 02/2013, Volume 23, Issue 2, pp. 270 - 280
In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for... 
OXIDATIVE STRESS | A-TYPE LAMINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CENTROMERES | ORGANIZATION | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | DYNAMICS | CHROMATIN INTERACTIONS | TELOMERES | Embryonic Stem Cells - metabolism | Conserved Sequence - genetics | Humans | Lamin Type A - metabolism | AT Rich Sequence | Lamin Type B - metabolism | Caenorhabditis elegans | Animals | Nuclear Lamina - metabolism | Mice | Genome | Drosophila melanogaster | Octamer Transcription Factor-1 - metabolism | Physiological aspects | Evolutionary genetics | Genetic aspects | Research | Cell differentiation | Embryonic stem cells | Gene expression | Metazoa
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5. Full Text Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells
by Kind, Jop and Pagie, Ludo and de Vries, Sandra S and Nahidiazar, Leila and Dey, Siddharth S and Bienko, Magda and Zhan, Ye and Lajoie, Bryan and de Graaf, Carolyn A and Amendola, Mario and Fudenberg, Geoffrey and Imakaev, Maxim and Mirny, Leonid A and Jalink, Kees and Dekker, Job and van Oudenaarden, Alexander and van Steensel, Bas
Cell, ISSN 0092-8674, 09/2015, Volume 163, Issue 1, pp. 134 - 147
Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL... 
CHROMATIN | HI-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | COMPARTMENTALIZATION | ARCHITECTURE | DYNAMICS | CHROMOSOMES | CONFORMATION | DOMAIN ORGANIZATION | PRINCIPLES | CELL BIOLOGY | Chromatin - metabolism | Genome-Wide Association Study | Nuclear Lamina - metabolism | Interphase | Single-Cell Analysis - methods | Humans | Cell Line, Tumor | Chromosomes - metabolism | In Situ Hybridization, Fluorescence | Chromosomes - chemistry | Chromatin - chemistry | Genetic research | Chromosomes | Analysis | Genomics | Cells | Chromatin | Genes | Genomes
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6. Full Text DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina
by Zullo, Joseph M and Demarco, Ignacio A and Piqué-Regi, Roger and Gaffney, Daniel J and Epstein, Charles B and Spooner, Chauncey J and Luperchio, Teresa R and Bernstein, Bradley E and Pritchard, Jonathan K and Reddy, Karen L and Singh, Harinder
Cell, ISSN 0092-8674, 06/2012, Volume 149, Issue 7, pp. 1474 - 1487
A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina... 
ORGANIZATION | MAINTENANCE | GAGA FACTOR | PROTEIN | DEACETYLATION | PERIPHERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TRANSCRIPTION FACTOR | MAMMALIAN-CELLS | LOCUS | CELL BIOLOGY | NIH 3T3 Cells | Mitosis | Gene Silencing | Histone Deacetylases - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Nuclear Envelope - metabolism | DNA - chemistry | Animals | Nuclear Lamina - metabolism | Base Sequence | Cytochrome P-450 Enzyme System - genetics | Transcription, Genetic | Mice | Drosophila - metabolism | Chromatin - genetics | Immunoglobulin Heavy Chains - genetics | Animal genetics | Chromatin | Molecular genetics | DNA | Genes | Genetic research | Nucleotide sequencing | DNA sequencing
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7. Full Text Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
by Osorio, Fernando G and BĂ¡rcena, Clea and Soria-Valles, Clara and Ramsay, Andrew J and de Carlos, FĂ©lix and Cobo, Juan and Fueyo, Antonio and Freije, JosĂ© M.P and LĂ³pez-OtĂ­n, Carlos
Genes and Development, ISSN 0890-9369, 10/2012, Volume 26, Issue 20, pp. 2311 - 2324
Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic... 
Nuclear envelope | Progeroid laminopathies | Longevity | MICE DEFICIENT | DNA-DAMAGE RESPONSE | nuclear envelope | EXTENDS LONGEVITY | DEVELOPMENTAL BIOLOGY | CANCER | CELL BIOLOGY | HUTCHINSON-GILFORD-PROGERIA | MOUSE MODEL | ENVELOPE | GENETICS & HEREDITY | longevity | SENESCENCE | EXPRESSION | NEMO | progeroid laminopathies | Metalloendopeptidases - genetics | Longevity - drug effects | Humans | Metalloendopeptidases - deficiency | Transcriptional Activation - drug effects | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Sodium Salicylate - pharmacology | Transcription Factor RelA - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | DNA-Binding Proteins - metabolism | Membrane Proteins - deficiency | Aging - immunology | Nuclear Lamina - metabolism | Cellular Senescence | Nuclear Lamina - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Signal Transduction | Membrane Proteins - genetics | Lamin Type A | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Longevity - genetics | Aging - pathology | Protein Precursors - metabolism | Animals | Aging - physiology | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Mice | Nuclear Lamina - enzymology | Inflammation - enzymology | Inflammation - physiopathology | Transcription factors | Aging | Physiological aspects | Genetic aspects | Inflammation | Research | Risk factors | Research Paper
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8. Full Text Transcriptional repression mediated by repositioning of genes to the nuclear lamina
by Reddy, K.L and Zullo, J.M and Bertolino, E and Singh, H
Nature, ISSN 0028-0836, 03/2008, Volume 452, Issue 7184, pp. 243 - 247
Nuclear compartmentalization seems to have an important role in regulating metazoan genes(1,2). Although studies on immunoglobulin and other loci have shown a... 
ORGANIZATION | EMERIN | MULTIDISCIPLINARY SCIENCES | MEMBRANE PROTEIN | COMPARTMENTALIZATION | ARCHITECTURE | CELL DIFFERENTIATION | LOCUS | ASSOCIATION | EXPRESSION | GENOME | Chromosome Positioning | Mitosis | Gene Silencing | Genes, Reporter - genetics | Nuclear Proteins - metabolism | Lamin Type B - metabolism | DNA-Binding Proteins - metabolism | Animals | Biological Transport | Nuclear Lamina - metabolism | Fibroblasts | Nuclear Lamina - genetics | Transcription, Genetic | Adenine - metabolism | Membrane Proteins - metabolism | Mice | Models, Genetic | Acetylation | Histones - metabolism | Methylation | Immunoglobulin Heavy Chains - genetics | Genetic research | Molecules | Immunoglobulins | Genes
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9. Full Text Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation
by Peric-Hupkes, Daan and Meuleman, Wouter and Pagie, Ludo and Bruggeman, Sophia W.M and Solovei, Irina and Brugman, Wim and Gräf, Stefan and Flicek, Paul and Kerkhoven, Ron M and van Lohuizen, Maarten and Reinders, Marcel and Wessels, Lodewyk and van Steensel, Bas
Molecular Cell, ISSN 1097-2765, 05/2010, Volume 38, Issue 4, pp. 603 - 613
The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. To visualize this process in... 
CELLBIO | DNA | DEVBIO | ORGANIZATION | LANGUAGE | METHYLATION | REPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | TRANSCRIPTION | GENE-REGULATION | INDUCTION | RNA-POLYMERASE | PLURIPOTENT | CELL BIOLOGY | Astrocytes - cytology | Chromosome Positioning | Cell Lineage | Animals | Embryonic Stem Cells - cytology | Nuclear Lamina - metabolism | Drosophila | Humans | Neurons - cytology | Cell Differentiation | Mice | Genome | Electrical engineering | Computer science | Anopheles | Molecular genetics | Genomes | Universities and colleges | Gene expression | Embryonic stem cells | Genetic transcription | Genes | Genomics
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10. Full Text Genome–nuclear lamina interactions and gene regulation
by Kind, Jop and van Steensel, Bas
Current Opinion in Cell Biology, ISSN 0955-0674, 2010, Volume 22, Issue 3, pp. 320 - 325
The nuclear lamina, a filamentous protein network that coats the inner nuclear membrane, has long been thought to interact with specific genomic loci and... 
Internal Medicine | ORGANIZATION | POSITION | CHROMATIN | REPRESSION | PERIPHERY | PROTEOME | ENVELOPE | ARCHITECTURE | EXPRESSION | CELL BIOLOGY | Animals | Nuclear Lamina - metabolism | Humans | Gene Expression Regulation | Genome - genetics | Mitosis - genetics | Nuclear Pore - metabolism
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11. Full Text Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
by Chen, Chun-Kan and Blanco, Mario and Jackson, Constanza and Aznauryan, Erik and Ollikainen, Noah and Surka, Christine and Chow, Amy and Cerase, Andrea and McDonel, Patrick and Guttman, Mitchell
Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6311, pp. 468 - 472
The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional... 
FACULTATIVE HETEROCHROMATIN | INACTIVATION | CELLS | LOCALIZATION | MOTION | RNA | MULTIDISCIPLINARY SCIENCES | GENES | GENOME | Cell Line | X Chromosome Inactivation - genetics | Transcriptional Activation | Gene Silencing | RNA, Long Noncoding - genetics | X Chromosome - metabolism | Animals | Nuclear Lamina - metabolism | Female | Transcription, Genetic | Mice | RNA, Long Noncoding - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | RNA sequencing | Physiological aspects | Gene expression | Observations | Chromosomes | Methods | Cellular biology | Ribonucleic acid--RNA | Proteins | Receptors | Silence | Genes | Deoxyribonucleic acid | Laminates | Recruitment
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12. Full Text Mechanisms and dynamics of nuclear lamina–genome interactions
by Amendola, Mario and van Steensel, Bas
Current Opinion in Cell Biology, ISSN 0955-0674, 2014, Volume 28, Issue 1, pp. 61 - 68
The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone... 
Internal Medicine | SUBNUCLEAR LOCALIZATION | TRANSCRIPTION FACTOR MOK2 | A-TYPE LAMINS | EMERIN IN-VITRO | EMBRYONIC STEM-CELLS