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Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 12/2012, Volume 2012, Issue 1, pp. e00047 - e00047
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory... 
NEUTROPHIL EXTRACELLULAR TRAPS | INTRACELLULAR DNA | DAI DLM-1/ZBP1 | MAMMALIAN DNA | IN-VIVO | BIOLOGY | V(D)J RECOMBINATION | DEPENDENT PROTEIN-KINASE | CYTOSOLIC DNA | AUTOIMMUNE-DISEASE | CYTOPLASMIC DNA | Embryo, Mammalian | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | DNA-Binding Proteins - deficiency | Vaccinia virus - immunology | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Herpesvirus 1, Human - immunology | Influenza A virus - immunology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Fibroblasts - virology | DNA-Binding Proteins - immunology | Signal Transduction | Gene Expression Regulation - immunology | Membrane Proteins - genetics | DNA, Viral - metabolism | Protein-Serine-Threonine Kinases - genetics | V(D)J Recombination | Membrane Proteins - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | DNA, Viral - immunology | Animals | DNA Repair - immunology | Interferon Type I - genetics | Fibroblasts - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Primary Cell Culture | DNA-Activated Protein Kinase - immunology | Cytokines - biosynthesis | Protein kinase C | Severe combined immunodeficiency | Transcription | Genes | Viruses | Innate immunity | Infections | Kinases | DNA repair | Proteins | Fibroblasts | Sensors | Localization | Deoxyribonucleic acid--DNA | RNA viruses | Fractionation | Statistical analysis | Cytokines | V(D)J recombination | Inflammation | RNA polymerase | Pattern recognition | DNA viruses | DNA-dependent protein kinase | Interferon regulatory factor 3 | Cytoplasm | Chemokines | Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 04/2013, Volume 13, Issue 4, pp. 395 - 405
Histone posttranslational modifications control eukaryotic gene expression and regulate many biological processes including immunity. Pathogens alter host... 
COMPLEX | METHYLATION | PROTEIN | METHYLTRANSFERASE | VIROLOGY | ACETYLATION | STRATEGY | TARGETS | MICROBIOLOGY | HISTONE MODIFICATIONS | VIRULENCE | PARASITOLOGY | Gene Expression - genetics | Humans | Immunity, Innate - genetics | Molecular Sequence Data | Legionella pneumophila - genetics | Promoter Regions, Genetic - genetics | Chromatin - immunology | Gene Expression - immunology | Bacterial Proteins - immunology | Nuclear Proteins - genetics | Amino Acid Sequence | Cell Line | Legionella pneumophila - immunology | Histones - immunology | Bacterial Proteins - genetics | Nuclear Proteins - immunology | Immunity, Innate - immunology | Sequence Alignment | Histones - genetics | DNA Replication - immunology | DNA Replication - genetics | Transcription, Genetic - immunology | Promoter Regions, Genetic - immunology | Transcription, Genetic - genetics | Methylation | Chromatin - genetics | Chromatin | Analysis | Genes | Transferases | Histones | Legionella pneumophila | Bacterial genetics | Gene expression | Index Medicus | Bacterial Proteins/immunology | Nuclear Proteins/immunology | Promoter Regions, Genetic/genetics | DNA Replication/genetics | Cellular Biology | Chromatin/immunology | Legionella pneumophila/genetics | Life Sciences | DNA Replication/immunology | Transcription, Genetic/genetics | Transcription, Genetic/immunology | Nuclear Proteins/genetics | Immunity, Innate/immunology | Promoter Regions, Genetic/immunology | Immunity, Innate/genetics | Histones/immunology | Bacterial Proteins/genetics | Legionella pneumophila/immunology | Chromatin/genetics | Gene Expression/immunology | Histones/genetics | Gene Expression/genetics
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3981 - 3991
Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated... 
CD4+T CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TCR | THERAPY | RECOGNITION | ANTI-CTLA-4 | MUTATIONAL LANDSCAPE | CD4(+) | ANTIGENS | BLOCKADE | Humans | Middle Aged | Neoplasm Proteins - immunology | Molecular Sequence Data | Male | Antigen-Antibody Reactions | Epitopes - immunology | Exome | Melanoma - genetics | Peptide Fragments - immunology | Adult | Female | Receptor, ErbB-2 - immunology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Transcription Factors - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | DNA-Binding Proteins - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Interferon-gamma Release Tests | Cells, Cultured | HLA-A1 Antigen - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Epitopes - genetics | Nuclear Proteins - immunology | Melanoma - secondary | HLA-A2 Antigen - chemistry | Algorithms | Genes, erbB-2 | Melanoma - immunology | Adolescent | RNA, Neoplasm - genetics | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | HLA-A1 Antigen - immunology | DNA, Neoplasm - genetics | Mutation | Antigens, Neoplasm - classification | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | T cells | Lymphocytes | Identification and classification | Health aspects | Tumors | Antigens | Peptides | Cloning | Melanoma | T cell receptors | Metastasis | Cancer therapies | Patients | Studies | Immunotherapy | Cancer | Index Medicus | Abridged Index Medicus
Journal Article