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Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 4, pp. 608 - 621.e6
Transcription is a source of genetic instability that can notably result from the formation of genotoxic DNA:RNA hybrids, or R-loops, between the nascent mRNA... 
genetic instability | intron | recombination | mRNA splicing | transcription | mRNP | R-loops | messenger ribonucleoparticle | ELONGATION IMPAIRMENT | YEAST | MESSENGER-RNA | CANDIDA-GLABRATA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOBAL ANALYSIS | R-LOOP FORMATION | SACCHAROMYCES-CEREVISIAE | EXPRESSION | SCHIZOSACCHAROMYCES-POMBE | REVEALS | CELL BIOLOGY | Genomic Instability | Nucleic Acid Heteroduplexes - genetics | DNA, Fungal - genetics | Spliceosomes - genetics | Saccharomyces cerevisiae - genetics | Humans | Cryptococcus neoformans - genetics | Databases, Genetic | DNA, Fungal - chemistry | Structure-Activity Relationship | Nucleic Acid Heteroduplexes - metabolism | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins - genetics | Transcription, Genetic | RNA, Fungal - genetics | Nucleic Acid Conformation | Gene Expression Regulation, Fungal | Cell Line | Introns | RNA, Fungal - chemistry | Computational Biology | Genotype | Ribonucleoproteins - metabolism | Fungal Proteins - genetics | Candida glabrata - metabolism | Cryptococcus neoformans - metabolism | Nucleic Acid Heteroduplexes - chemistry | RNA, Fungal - metabolism | Schizosaccharomyces - metabolism | Phenotype | DNA, Fungal - metabolism | DNA Damage | Candida glabrata - genetics | Fungal Proteins - metabolism | RNA | Analysis | Genes | Genomics | Genetic research | Genetic aspects | Genetic transcription | Anopheles | Messenger RNA | Cryptococcus neoformans | Life Sciences | RNA, Fungal | Spliceosomes | Schizosaccharomyces | Biochemistry, Molecular Biology | Ribonucleoproteins | Fungal Proteins | Candida glabrata | DNA, Fungal | Nucleic Acid Heteroduplexes | Molecular biology | Saccharomyces cerevisiae
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 4, pp. 633 - 645.e3
The RNA-guided Cpf1 (also known as Cas12a) nuclease associates with a CRISPR RNA (crRNA) and cleaves the double-stranded DNA target complementary to the crRNA... 
CRISPR-Cas | Cpf1 | crystal structure | protospacer adjacent motif | Cas12a | SYSTEM | COMPLEX | ENDONUCLEASE | DUAL-RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | GUIDE RNA | CAS9 | TARGET DNA RECOGNITION | REVEALS | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | Nucleic Acid Heteroduplexes - genetics | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Bacterial Proteins - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Endonucleases - metabolism | Nucleic Acid Heteroduplexes - metabolism | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Clostridiales - genetics | Acidaminococcus - genetics | Nucleic Acid Conformation | Binding Sites | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Acidaminococcus - enzymology | DNA - metabolism | Endonucleases - chemistry | Nucleic Acid Heteroduplexes - chemistry | DNA - genetics | DNA - chemistry | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Protein Binding | Bacterial Proteins - metabolism | Protein Conformation | Clostridiales - enzymology | Nucleases | DNA binding proteins | RNA | Structure | Genomics | Crystals | Enzymes
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 2, pp. 310 - 322
C2c1 is a type V-B CRISPR-Cas system dual-RNA-guided DNA endonuclease. Here, we report the crystal structure of C2c1 in complex with a chimeric single-molecule... 
crystal structure | CRISPR-Cas system | C2c1 | genome-editing | DNA endonuclease | CRISPR-CAS SYSTEMS | ADAPTIVE IMMUNITY | ENDONUCLEASE | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | TARGET DNA | CLASSIFICATION | RESOLVASE | PROKARYOTES | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Nucleic Acid Heteroduplexes - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | DNA Breaks, Double-Stranded | Nucleic Acid Heteroduplexes - metabolism | Alicyclobacillus - enzymology | Alicyclobacillus - genetics | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | Endodeoxyribonucleases - metabolism | RNA, Bacterial - genetics | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | RNA, Bacterial - metabolism | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Endodeoxyribonucleases - chemistry | Nucleic Acid Heteroduplexes - chemistry | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Protein Binding | Bacterial Proteins - metabolism | Nucleases | RNA | Analysis | Genomics | DNA | Crystals | Structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30161 - 30171
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 121, Issue 7, pp. 1005 - 1016
Journal Article