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Immunity, ISSN 1074-7613, 07/2014, Volume 41, Issue 1, pp. 127 - 140
Memory CD8 T cells are programmed during the primary response for robust secondary responsiveness. Here we show that CD8 T cells responding to different... 
IMMUNODOMINANCE | EFFECTOR | RESPONSES | VIRUS-INFECTION | DENDRITIC CELLS | CD8-T-CELL MEMORY | CD4-T-CELL HELP | CD40 LIGAND | IMMUNOLOGY | VIRAL-INFECTION | CROSS-PRESENTATION | Antigens, CD - immunology | CD40 Antigens - antagonists & inhibitors | Minor Histocompatibility Antigens | Dendritic Cells - immunology | Interleukin-2 Receptor alpha Subunit - biosynthesis | Adoptive Transfer | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Integrin alpha Chains - immunology | Influenza A virus - immunology | CD40 Antigens - genetics | Histocompatibility Antigens Class I - pharmacology | Epitopes, T-Lymphocyte - immunology | Immunologic Memory - immunology | Nucleoproteins - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | CD11b Antigen - immunology | CD27 Ligand - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | DNA-Directed RNA Polymerases - immunology | Mice, Transgenic | Antigen Presentation - immunology | Animals | Viral Core Proteins - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Interferon-gamma - biosynthesis | Orthomyxoviridae Infections - immunology | Flow cytometry | Antigens | Lymphocytes | Ligands | T cell receptors | Infections | Experiments | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62778
Current influenza vaccines stimulate neutralising antibody to the haemagglutinin antigen but as there is antigenic drift in HA it is difficult to prepare a... 
EFFECTOR | CROSS-REACT | INFECTIONS | PROTECTION | RECOGNITION | MULTIDISCIPLINARY SCIENCES | HUMANS | PHENOTYPE | A-VIRUS | RECIPIENTS | LYMPHOCYTES | HLA-A2 Antigen - genetics | Influenza Vaccines - administration & dosage | Viral Matrix Proteins - genetics | Perforin - genetics | Humans | Middle Aged | Nucleoproteins - genetics | Vaccination | Viral Vaccines - genetics | Antigens, Viral - genetics | Epitopes, T-Lymphocyte - genetics | Granzymes - genetics | Hemagglutinins - immunology | Orthomyxoviridae - immunology | Adult | Granzymes - immunology | Orthomyxoviridae - drug effects | Perforin - immunology | Epitopes, T-Lymphocyte - immunology | Nucleoproteins - immunology | CD57 Antigens - immunology | HLA-A2 Antigen - immunology | Recombinant Proteins - genetics | Viral Vaccines - administration & dosage | Hemagglutinins - genetics | Antigens, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - virology | Influenza, Human - genetics | Viral Core Proteins - genetics | Adolescent | CD57 Antigens - genetics | Vaccines, Synthetic | Viral Core Proteins - immunology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Influenza, Human - prevention & control | Viral Vaccines - immunology | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Proteins | Medical research | Influenza | Medicine, Experimental | T cells | Antigenic determinants | CD57 antigen | Flow cytometry | CD8 antigen | Cytotoxicity | Viruses | Infections | Lymphocytes T | Vaccines | Avian flu | Genotype & phenotype | Hepatitis | Immunology | Lymphocytes | Perforin | Antigens | Immunization | Antigenic drift | T cell receptors | Epitopes | CD4 antigen | Medicine | Studies | Swine flu | Histocompatibility antigen HLA | Drift
Journal Article
Journal of clinical investigation, ISSN 0021-9738, 2008, Volume 118, Issue 10, pp. 3478 - 3490
The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the... 
MEDICINE, RESEARCH & EXPERIMENTAL | MEDIATED PROTECTION | EPITOPE | VIRUS MATRIX PROTEIN | CTL RESPONSE | VACCINE | PERIPHERAL-BLOOD | RANDOMIZED CONTROLLED-TRIAL | LYMPHOCYTES-T | HUMAN CD8(+) | ANTIGEN
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30898
Background: The inability of seasonal influenza vaccines to effectively protect against infection with antigenically drifted viruses or newly emerging pandemic... 
A VIRUS | IMMUNITY | H5N1 | T-CELL RESPONSES | RECOGNITION | NUCLEOPROTEIN | MULTIDISCIPLINARY SCIENCES | GLYCOPROTEINS | EXOGENOUS ANTIGENS | MECHANISMS | IMMUNOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Species Specificity | Humans | Vaccination | Body Weight - drug effects | Virus Inactivation - drug effects | Cross Protection - drug effects | Propiolactone - pharmacology | Virus Internalization - drug effects | Hemagglutination Inhibition Tests | T-Lymphocytes, Cytotoxic - drug effects | Antibodies, Neutralizing - immunology | Cross Protection - immunology | Lung - virology | Influenza, Human - virology | Nucleoproteins - immunology | T-Lymphocytes, Cytotoxic - immunology | Immune Sera - immunology | Lung - pathology | Immune Sera - drug effects | Formaldehyde - pharmacology | Influenza A Virus, H5N1 Subtype - drug effects | Influenza A Virus, H1N1 Subtype - drug effects | Viral Load - immunology | Vaccines, Inactivated - immunology | Animals | Influenza Vaccines - immunology | Influenza A Virus, H5N1 Subtype - immunology | Lung - drug effects | Survival Analysis | Antibodies, Viral - immunology | Mice | Viral Load - drug effects | Influenza, Human - prevention & control | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Influenza vaccines | Antigens | Medical research | Body weight | Development and progression | Research | T cells | Formaldehyde | Infection | Avian influenza | Medicine, Experimental | Health aspects | Pandemics | CD8 antigen | Clinical trials | Cytotoxicity | Viruses | Infections | Biochemistry | Lymphocytes T | Body weight loss | Vaccines | Inactivation | Immunity | Avian flu | Proteins | Granzyme B | Lymphocytes | Cross-protection | Matrix protein | Spleen | Membrane fusion | Deactivation | Virology | Studies | Lungs | Immunogenicity | Swine flu | Influenza
Journal Article
Journal of Virology, ISSN 0022-538X, 08/2012, Volume 86, Issue 15, pp. 8245 - 8258
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
VIROLOGY | RNA | RECOGNITION | MATRIX PROTEIN | CYTOPLASMIC INCLUSIONS | RIG-I | INFECTED-CELLS | IDENTIFICATION | NF-KAPPA-B | NONSTRUCTURAL PROTEINS | PROXIMITY LIGATION | Respiratory Syncytial Virus, Human - metabolism | Genome, Viral - genetics | Humans | Newcastle Disease - immunology | Respiratory Syncytial Virus Infections - metabolism | RNA, Messenger - metabolism | Viral Proteins - metabolism | Interferon-Induced Helicase, IFIH1 | Respiratory Syncytial Virus, Human - genetics | Adaptor Proteins, Signal Transducing - immunology | Interferon-beta - genetics | Newcastle disease virus - immunology | Vero Cells | DEAD Box Protein 58 | Intranuclear Inclusion Bodies - genetics | Viral Proteins - genetics | Nucleoproteins - metabolism | Respiratory Syncytial Virus, Human - immunology | Cell Line, Tumor | DEAD-box RNA Helicases - immunology | Respiratory Syncytial Virus Infections - pathology | Intranuclear Inclusion Bodies - metabolism | Newcastle Disease - genetics | RNA, Messenger - immunology | Interferon-beta - immunology | Nucleoproteins - genetics | Viral Proteins - immunology | Cercopithecus aethiops | Respiratory Syncytial Virus Infections - immunology | Newcastle Disease - metabolism | Intranuclear Inclusion Bodies - immunology | RNA, Viral - genetics | Genome, Viral - immunology | RNA, Viral - metabolism | DEAD-box RNA Helicases - metabolism | Newcastle Disease - pathology | Nucleoproteins - immunology | Intranuclear Inclusion Bodies - virology | RNA, Messenger - genetics | Newcastle disease virus - metabolism | Interferon-beta - biosynthesis | Respiratory Syncytial Virus Infections - genetics | Birds | Immunity, Innate | Intranuclear Inclusion Bodies - pathology | DEAD-box RNA Helicases - genetics | Animals | Newcastle disease virus - genetics | Adaptor Proteins, Signal Transducing - genetics | RNA, Viral - immunology | Adaptor Proteins, Signal Transducing - metabolism | Virus-Cell Interactions
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 35, Issue 5, pp. 757 - 766
Highlights • A single dose of 3 × 105 CFUs of rBCG-N-hRSV cGMP elicits T-cell memory against hRSV. • rBCG-N-hRSV cGMP elicits a strong antiviral TH1/TH17... 
Allergy and Immunology | Human respiratory syncytial virus | Pulmonary inflammation | Bacillus Calmette et Guerin | T cells | Th1 | Viral infection | Th17 | Recombinant vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | RECRUITMENT | DENDRITIC CELLS | ENHANCED DISEASE | INFLUENZA | IMMUNOLOGY | PULMONARY EOSINOPHILIA | RESPONSES | INFANTS | ALVEOLAR MACROPHAGES | EXPRESSION | YOUNG-CHILDREN | Immunogenicity, Vaccine | Respiratory Syncytial Virus Vaccines - immunology | Humans | Nucleoproteins - genetics | Interleukin-17 - immunology | Viral Proteins - immunology | Th1 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Th17 Cells - virology | Th1 Cells - virology | BCG Vaccine - genetics | Lung - virology | Th17 Cells - drug effects | Immunity, Cellular - drug effects | Respiratory Syncytial Virus Infections - prevention & control | Immunization Schedule | Respiratory Syncytial Virus Infections - virology | Respiratory Syncytial Virus, Human - pathogenicity | Nucleoproteins - immunology | Th1 Cells - drug effects | Respiratory Syncytial Virus, Human - drug effects | Viral Proteins - genetics | Interleukin-17 - biosynthesis | Animals | CD8-Positive T-Lymphocytes - virology | Lymphocyte Activation - drug effects | Respiratory Syncytial Virus, Human - immunology | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Lung - drug effects | Respiratory Syncytial Virus Vaccines - administration & dosage | BCG Vaccine - immunology | Th17 Cells - immunology | Vaccines, Synthetic | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Respiratory Syncytial Virus Vaccines - genetics | BCG Vaccine - administration & dosage | Interferon-gamma - biosynthesis | Lung - immunology | Virus diseases | Prevention | Vaccines | Health aspects | Antigens | Pneumonia | Vaccination | Bacterial pneumonia | Disease susceptibility | Epidemics | Pathogenesis | Neutrophils | Viruses | T cell receptors | Infections | Pathology | Immunology | Respiratory syncytial virus | Lungs | Lymphocytes | Laboratory animals | Public health | Life Sciences | Human health and pathology
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1839 - 1844
Ecology is typically thought of as the study of interactions organisms have with each other and their environment and is focused on the distribution and... 
T lymphocytes | Antigens | Immune response | Nucleotide sequences | Amino acids | Mice | Infections | Epitopes | Immunity | T cell antigen receptors | Killer T cells | Antiviral immunity | antiviral immunity | AFFINITY THRESHOLD | MULTIDISCIPLINARY SCIENCES | RECEPTOR RECOGNITION | CONVERGENT RECOMBINATION | PRECURSOR FREQUENCY | killer T cells | STRUCTURAL BASIS | TCR REPERTOIRES | IN-VIVO | RESPONSE MAGNITUDE | HETEROLOGOUS IMMUNITY | VIRUS NUCLEOPROTEIN EPITOPE | T-Lymphocytes - metabolism | Base Sequence | CD8-Positive T-Lymphocytes - metabolism | Influenza A virus - immunology | Receptors, Antigen, T-Cell - immunology | Epitopes, T-Lymphocyte - immunology | Complementarity Determining Regions - metabolism | Nucleoproteins - immunology | T-Lymphocytes, Cytotoxic - immunology | Amino Acid Sequence | Receptors, Antigen, T-Cell - metabolism | Orthomyxoviridae Infections - metabolism | Peptides - immunology | Clonal Selection, Antigen-Mediated - immunology | Proteins - immunology | Antigens, Viral - immunology | Models, Immunological | Animals | Proteins - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Nucleoproteins - metabolism | Complementarity Determining Regions - immunology | Antigens - immunology | T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - immunology | Antiviral agents | Antigen receptors, T cell | Receptors | Research | Properties | T cells | Antigenic determinants | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e55435
Among approximately 1000 adenoviruses from chimpanzees and bonobos studied recently, the Pan Adenovirus type 3 (PanAd3, isolated from a bonobo, Pan paniscus)... 
IMMUNITY | IMMUNOGENICITY | NEUTRALIZING ANTIBODIES | EFFICACY | A VIRUSES | NUCLEOPROTEIN | DNA | MULTIDISCIPLINARY SCIENCES | GENE-TRANSFER | CD8(+) T-CELLS | LYMPHOCYTES | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Recombinant Fusion Proteins - immunology | RNA-Binding Proteins - genetics | Adenoviruses, Simian - immunology | Influenza Vaccines - administration & dosage | Viral Matrix Proteins - genetics | Genetic Vectors - administration & dosage | Humans | Immunity, Mucosal | Molecular Sequence Data | Antigens, Viral - genetics | Antibodies, Viral - blood | Adenoviruses, Simian - genetics | Antibodies, Neutralizing - immunology | Female | Influenza A Virus, H1N1 Subtype - genetics | Amino Acid Sequence | Viral Core Proteins - chemistry | Gene Expression | Genetic Vectors - immunology | Adenoviruses, Human - immunology | RNA-Binding Proteins - chemistry | RNA-Binding Proteins - immunology | Pan paniscus | Recombinant Fusion Proteins - chemistry | Cross Reactions - immunology | Genetic Vectors - genetics | Antigens, Viral - immunology | Animals | Influenza Vaccines - immunology | Viral Matrix Proteins - chemistry | Viral Core Proteins - genetics | Recombinant Fusion Proteins - genetics | Antibodies, Viral - immunology | T-Lymphocytes - immunology | Viral Core Proteins - immunology | Mice | Viral Matrix Proteins - immunology | Influenza viruses | Influenza vaccines | Antigens | Medical research | Viral proteins | Adenoviruses | Influenza | Vaccination | Medicine, Experimental | Drug therapy, Combination | T cells | Immunoglobulins | Chimpanzees | Viruses | Population studies | Lymphocytes T | Intranasal administration | T cell receptors | Vaccines | Immunity | Avian flu | Vectors (Biology) | Defects | Human populations | Proteins | Immunogenicity | Lymphocytes | Gene therapy | Fusion protein | Food
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 3, p. e1003207
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33428
The prevalence of preexisting immunity to adenoviruses in the majority of the human population might adversely impact the development of adaptive immune... 
RESPONSES | NEUTRALIZING ANTIBODIES | VIRAL-ANTIGENS | VIRUS | REPLICATION | BOVINE | MOUSE MODEL | BIOLOGY | MICE | CELL-LINES | RECOMBINANT ADENOVIRUS | Orthomyxoviridae Infections - prevention & control | Immunity, Humoral - immunology | Humans | Interferon-gamma - metabolism | Epitopes - immunology | Hemagglutination Inhibition Tests | Antibodies, Neutralizing - immunology | Reassortant Viruses - immunology | Viral Core Proteins - metabolism | Adenoviridae - genetics | Influenza, Human - virology | Immunization | Immunity - immunology | Adenoviridae - physiology | Virus Replication - immunology | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Genetic Vectors - genetics | Immunity, Cellular - immunology | Animals | Influenza Vaccines - immunology | Influenza A Virus, H5N1 Subtype - immunology | Antibodies, Viral - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Influenza, Human - prevention & control | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | RNA-Binding Proteins - metabolism | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Avian influenza | Viral proteins | Adenoviruses | Vaccination | Lectins | Genes | Viruses | Infections | Vaccines | Veterinary medicine | Immunity | Avian flu | Human populations | Proteins | Inoculation | Hemagglutinins | Deoxyribonucleic acid--DNA | Encephalitis | Antigens | Cytomegalovirus | Immunoglobulins | Immune response | Cytokines | Priming | Disease control | Disease prevention | Studies | Immunogenicity | Influenza | Neutralization | Nucleoproteins | Plaques | Expression vectors | Deoxyribonucleic acid | DNA
Journal Article