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Journal of Clinical Investigation, ISSN 0021-9738, 2012, Volume 122, Issue 2, pp. 693 - 710
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2012, Volume 446, Issue 2, pp. 179 - 190
Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for... 
Immucillin | Adenine | Purine transporter | Plasmodium | Adenosine | Equilibrative nucloside transporter 4 (ENT4) | BIOCHEMISTRY & MOLECULAR BIOLOGY | equilibrative nucloside transporter 4 (ENT4) | FUNCTIONAL-CHARACTERIZATION | SALVAGE PATHWAYS | CYTOKININ | PLASMA-MEMBRANE | adenosine | immucillin | purine transporter | XENOPUS-LAEVIS OOCYTES | PLASMODIUM-FALCIPARUM | adenine | PROTEINS | EXPRESSION | PFNT1 | Equilibrative Nucleoside Transport Proteins - metabolism | Protozoan Proteins - antagonists & inhibitors | Substrate Specificity | Cytokinins - pharmacology | Protozoan Proteins - genetics | Protein Isoforms - metabolism | Protozoan Proteins - metabolism | Equilibrative Nucleoside Transport Proteins - chemistry | Dipyridamole - pharmacology | Membrane Transport Modulators - pharmacology | Oocytes - drug effects | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Biological Transport - drug effects | Recombinant Proteins - metabolism | Plasmodium vivax - metabolism | Recombinant Proteins - antagonists & inhibitors | Protein Structure, Secondary | Oocytes - metabolism | Xenopus laevis | Phosphodiesterase Inhibitors - pharmacology | Recombinant Proteins - chemistry | Equilibrative Nucleoside Transport Proteins - antagonists & inhibitors | Deoxyadenosines - metabolism | Animals | Adenine - metabolism | Kinetics | Plant Growth Regulators - pharmacology | Equilibrative Nucleoside Transport Proteins - genetics | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | metabolism
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 2102 - 2111
Journal Article
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 03/2015, Volume 10, Issue 3, pp. 775 - 783
Equilibrative transporters are potential drug targets; however, most functional assays involve radioactive substrate uptake that is unsuitable for... 
ANTIMALARIAL-DRUG | TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURINE SALVAGE | PERMEASE | APICOPLAST | PROTEINS | SACCHAROMYCES-CEREVISIAE | PLASMA-MEMBRANE | PFNT1 | CHEMOTHERAPY | Small Molecule Libraries - pharmacology | Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins - genetics | Protozoan Proteins - antagonists & inhibitors | Saccharomyces cerevisiae - genetics | Trophozoites - metabolism | Uridine - analogs & derivatives | Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins - antagonists & inhibitors | Saccharomyces cerevisiae - drug effects | Nucleoside Transport Proteins - metabolism | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Protozoan Proteins - genetics | Genetic Complementation Test | Trophozoites - growth & development | Saccharomyces cerevisiae - metabolism | Trophozoites - drug effects | Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins - metabolism | Protozoan Proteins - metabolism | Gene Deletion | Plasmodium falciparum - metabolism | Biological Transport - drug effects | Gene Expression | Nucleoside Transport Proteins - genetics | Axenic Culture | Saccharomyces cerevisiae Proteins - genetics | Uridine - pharmacology | Antimalarials - pharmacology | Small Molecule Libraries - chemistry | High-Throughput Screening Assays | Antimalarials - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Plasmodium falciparum - growth & development | drug development | malaria | purine transport
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2006, Volume 103, Issue 20, pp. 7895 - 7900
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2015, Volume 1342, Issue 1, pp. 19 - 28
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 11/2015, Volume 76, Issue 5, pp. 1093 - 1098
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2004, Volume 318, Issue 2, pp. 372 - 380
5-Aminoimidazole-4-carboxamide riboside (AICAR) is an adenosine analog and a widely used activator of AMP-activated protein kinase (AMPK). We examined the... 
SKELETAL-MUSCLE | CELLS | OXIDATIVE STRESS | BIOPHYSICS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | ADENOSINE | KAPPA-B | PROTEIN-KINASE ACTIVITY | CYTOKINE EXPRESSION | ACADESINE | Purinergic P1 Receptor Antagonists | Phosphorylation | Multienzyme Complexes - metabolism | Male | Nucleoside Transport Proteins - antagonists & inhibitors | Adenosine Kinase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Lipopolysaccharides - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | AMP-Activated Protein Kinases | Aminoimidazole Carboxamide - pharmacology | Ribonucleotides - pharmacology | RNA, Messenger - biosynthesis | RNA, Messenger - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Macrophages - enzymology | Proto-Oncogene Proteins c-akt | Macrophages - metabolism | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Adenosine - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
Journal Article