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1. Full Text Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine
by Bertoletti, Nicole and Chan, Albert H and Schinazi, Raymond F and Yin, Y. Whitney and Anderson, Karen S
Protein science, ISSN 0961-8368, 09/2019, Volume 28, Issue 9, pp. 1664 - 1675
emtricitabine | nucleoside reverse transcriptase inhibitors | macromolecular X‐ray crystallography | inhibitor–protein complexes | lamivudine | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | DNA Polymerase gamma - metabolism | Emtricitabine - adverse effects | Humans | Models, Molecular | Reverse Transcriptase Inhibitors - pharmacology | Crystallography, X-Ray | DNA Polymerase gamma - chemistry | Emtricitabine - chemistry | Structure-Activity Relationship | Emtricitabine - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Amino Acid Motifs | Lamivudine - adverse effects | Reverse Transcriptase Inhibitors - adverse effects | HIV Reverse Transcriptase - metabolism | Lamivudine - chemistry | Protein Conformation | Lamivudine - pharmacology | Binding Sites | HIV Reverse Transcriptase - chemistry | Drugs | Emtricitabine | Antiretroviral drugs | RNA-directed DNA polymerase | DNA polymerase | Toxicity | Amino acids | Lamivudine | Mitochondrial DNA | DNA biosynthesis | Highly active antiretroviral therapy | Side effects | Inhibitors | Antiretroviral agents | Nucleoside reverse transcriptase inhibitors | Human immunodeficiency virus--HIV | Nucleosides | Replication | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase | Crystal structure | Index Medicus | Full‐Length Papers
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2. Full Text Mechanism of inhibition of HIV-1 reverse transcriptase by 4′-ethynyl-2-fluoro-2′-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor
by Michailidis, Eleftherios and Marchand, Bruno and Kodama, Eiichi N and Singh, Kamlendra and Matsuoka, Masao and Kirby, Karen A and Ryan, Emily M and Sawani, Ali M and Nagy, Eva and Ashida, Noriyuki and Mitsuya, Hiroaki and Parniak, Michael A and Sarafianos, Stefan G
The Journal of biological chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 51, pp. 35681 - 35691
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Virus Replication - drug effects | Deoxyadenine Nucleotides - pharmacology | DNA, Viral - biosynthesis | Deoxyadenine Nucleotides - chemistry | Protein Structure, Secondary | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Reverse Transcription - drug effects | Models, Molecular | Reverse Transcriptase Inhibitors - pharmacology | HIV Infections - enzymology | Leukocytes, Mononuclear - virology | Reverse Transcriptase Inhibitors - chemistry | HIV Reverse Transcriptase - metabolism | Hydrophobic and Hydrophilic Interactions | HIV Infections - drug therapy | HIV-1 - enzymology | HIV Reverse Transcriptase - chemistry | Translocation | RNA-directed DNA polymerase | nucleoside reverse transcriptase inhibitors | Hydrophobicity | nucleic acids | DNA biosynthesis | Infection | Molecular modelling | nucleoside analogs | Primers | Antiviral activity | Peripheral blood mononuclear cells | Replication | Elongation | Index Medicus | DNA | Repair, Recombination, and Chromosome Dynamics | Medicin och hälsovetenskap
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3. Full Text Treatment outcomes of integrase inhibitors, boosted protease inhibitors and nonnucleoside reverse transcriptase inhibitors in antiretroviral‐naïve persons starting treatment
by Mocroft, A and Neesgard, B and Zangerle, R and Rieger, A and Castagna, A and Spagnuolo, V and Antinori, A and Lampe, FC and Youle, M and Vehreschild, JJ and Mussini, C and Borghi, V and Begovac, J and Duvivier, C and Gunthard, HF and Rauch, A and Tiraboschi, J and Chkhartishvili, N and Bolokadze, N and Wit, F and Wasmuth, JC and De Wit, S and Necsoi, C and Pradier, C and Svedhem, V and Stephan, C and Petoumenos, K and Garges, H and Rogatto, F and Peters, L and Ryom, L and RESPOND Study Grp and the RESPOND study group
HIV medicine, ISSN 1464-2662, 10/2020, Volume 21, Issue 9, pp. 599 - 606
protease inhibitors | integrase inhibitors | antiretroviral naïve | nonnucleoside reverse transcriptase inhibitors | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Integrase | Subpopulations | RNA-directed DNA polymerase | Health services | Clinical trials | Proteinase inhibitors | Ribonucleic acid--RNA | Success | Antiretroviral therapy | CD4 antigen | Consortia | Infectious diseases | Immunology | Non-nucleoside reverse transcriptase inhibitors | Protease inhibitors | Acquired immune deficiency syndrome--AIDS | Protease | Antiretroviral agents | Human immunodeficiency virus--HIV | Age | Index Medicus
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4. Full Text Impact of reverse transcriptase resistance on the efficacy of TMC125 (etravirine) with two nucleoside reverse transcriptase inhibitors in protease inhibitor‐naïve, nonnucleoside reverse transcriptase inhibitor‐experienced patients: study TMC125‐C227
by Ruxrungtham, K and Pedro, RJ and Latiff, GH and Conradie, F and Domingo, P and Lupo, S and Pumpradit, W and Vingerhoets, JH and Peeters, M and Peeters, I and Kakuda, TN and De Smedt, G and Woodfall, B and TMC125-C227 Study Grp and TMC125-C227 study group and on behalf of the TMC125-C227 study group (see Appendix)
HIV medicine, ISSN 1464-2662, 11/2008, Volume 9, Issue 10, pp. 883 - 896
etravirine | nonnucleoside reverse transcriptase inhibitor | HIV | resistance | Nonnucleoside reverse transcriptase inhibitor | Resistance | Etravirine | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | HIV Protease Inhibitors - adverse effects | HIV-1 | Drug Administration Schedule | Humans | Middle Aged | Male | CD4 Lymphocyte Count | HIV Protease Inhibitors - administration & dosage | Reverse Transcriptase Inhibitors - administration & dosage | Viral Load | Reverse Transcriptase Inhibitors - adverse effects | Young Adult | Reverse Transcriptase Inhibitors - pharmacokinetics | Epidemiologic Methods | HIV Protease Inhibitors - pharmacokinetics | RNA, Viral | Pyridazines - administration & dosage | Adult | Drug Resistance, Viral - drug effects | Female | HIV Infections - drug therapy | Pyridazines - pharmacokinetics | Antiretroviral Therapy, Highly Active - methods | Pyridazines - adverse effects | Antiviral agents | Medical research | Reverse transcriptase | Protease inhibitors | Proteases | Analysis | Nucleosides | Medicine, Experimental | Reverse transcriptase inhibitors | Universities and colleges | HIV (Viruses) | Anti-HIV agents | Index Medicus
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5. Full Text Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
by Benjamin J. Fowler and Bradley D. Gelfand and Younghee Kim and Nagaraj Kerur and Valeria Tarallo and Yoshio Hirano and Shoba Amarnath and Daniel H. Fowler and Marta Radwan and Mark T. Young and Keir Pittman and Paul Kubes and Hitesh K. Agarwal and Keykavous Parang and David R. Hinton and Ana Bastos-Carvalho and Shengjian Li and Tetsuhiro Yasuma and Takeshi Mizutani and Reo Yasuma and Charles Wright and Jayakrishna Ambati
Science (American Association for the Advancement of Science), ISSN 0036-8075, 11/2014, Volume 346, Issue 6212, pp. 1000 - 1003
T lymphocytes | Medical research | Phosphorylation | Transfection | RNA | HEK293 cells | Cell death | REPORTS | Nucleosides | Research grants | Dosage | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Retinal Pigment Epithelium - metabolism | Apoptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Reverse Transcriptase Inhibitors - pharmacology | Caspase 1 - metabolism | Geographic Atrophy - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hepatitis - drug therapy | Animals | Carrier Proteins - metabolism | Choroidal Neovascularization - drug therapy | Graft vs Host Disease - drug therapy | Inflammasomes - drug effects | Liver - drug effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Retinal Pigment Epithelium - physiology | Receptors, Purinergic P2X7 - metabolism | Mice | Reverse Transcriptase Inhibitors - therapeutic use | Alu Elements | Disease Models, Animal | Retinal Pigment Epithelium - drug effects | Prevention | Genetic research | Genetic aspects | Genetic transcription | Research | HIV (Viruses) | Virus research | Macular degeneration | Inhibitor drugs | Drug therapy | Ribonucleic acid--RNA | Human immunodeficiency virus--HIV | Index Medicus | Atrophy | Drugs | Inhibitors | Ribonucleic acids | Blocking | Activation | Grafting
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6. Full Text Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 - 2010)
by Zhan, Peng and Liu, Xinyong
Expert opinion on therapeutic patents, ISSN 1354-3776, 05/2011, Volume 21, Issue 5, pp. 717 - 796
inhibitors | AIDS | HIV | drug design | NNRTIs | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Animals | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Design | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Structure-Activity Relationship | Reverse Transcriptase Inhibitors - therapeutic use | Drug Discovery | Prodrugs - pharmacology | Patents as Topic | Reverse Transcriptase Inhibitors - chemistry | Antiviral agents | Patents | Pharmacodynamics | RNA-directed DNA polymerase | Toxicity | Drug development | Drug resistance | prodrugs | Side effects | Reviews | scaffolds | non-nucleoside reverse transcriptase inhibitors | Antiviral activity | Evolution | Pharmacokinetics | Index Medicus
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7. Full Text Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial
by Cohen, Calvin J, Dr and Andrade-Villanueva, Jaime, Prof and Clotet, Bonaventura, MD and Fourie, Jan, MD and Johnson, Margaret A, Prof and Ruxrungtham, Kiat, Prof and Wu, Hao, MD and Zorrilla, Carmen, MD and Crauwels, Herta, PhD and Rimsky, Laurence T, PhD and Vanveggel, Simon, MSc and Boven, Katia, MD and on behalf of the THRIVE study group and THRIVE Study Grp and THRIVE study group
The Lancet (British edition), ISSN 0140-6736, 2011, Volume 378, Issue 9787, pp. 229 - 237
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antiviral agents | General aspects | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Antibiotics. Antiinfectious agents. Antiparasitic agents | Rilpivirine | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Middle Aged | Male | Anti-HIV Agents - administration & dosage | Nitriles - administration & dosage | Tenofovir | Deoxycytidine - therapeutic use | Nucleotides - therapeutic use | Adenine - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Female | Reverse Transcriptase Inhibitors - therapeutic use | Acquired Immunodeficiency Syndrome - virology | Acquired Immunodeficiency Syndrome - ethnology | Emtricitabine | Nucleosides - therapeutic use | Adenine - analogs & derivatives | Benzoxazines - administration & dosage | Double-Blind Method | Drug Administration Schedule | Organophosphonates - therapeutic use | HIV-1 - drug effects | Pyrimidines - administration & dosage | Anti-HIV Agents - adverse effects | Benzoxazines - adverse effects | Treatment Outcome | HIV-1 - genetics | Acquired Immunodeficiency Syndrome - drug therapy | Benzoxazines - therapeutic use | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Mutation | Nitriles - adverse effects | Viral Load - drug effects | Deoxycytidine - analogs & derivatives | Nitriles - therapeutic use | Evaluation | Patient outcomes | Clinical trials | Dosage and administration | Drug therapy | HIV infection | Design | Antiretroviral drugs | Corporate sponsorship | Human immunodeficiency virus--HIV | Technological change | Research | Clinical medicine | Drugs | RNA-directed DNA polymerase | Exanthema | antiretroviral therapy | Lamivudine | Lipids | Nucleotides | Regression analysis | Efavirenz | CD4 antigen | nucleosides | Algorithms | Hospitals | non-nucleoside reverse transcriptase inhibitors | Abacavir | Zidovudine | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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8. Full Text Ultra-Deep Pyrosequencing of Hepatitis B Virus Quasispecies from Nucleoside and Nucleotide Reverse-Transcriptase Inhibitor (NRTI)–Treated Patients and NRTI-Naive Patients
by Severine Margeridon-Thermet and Nancy S. Shulman and Aijaz Ahmed and Rajin Shahriar and Tommy Liu and Chunlin Wang and Susan P. Holmes and Farbod Babrzadeh and Baback Gharizadeh and Bozena Hanczaruk and Birgitte B. Simen and Michael Egholm and Robert W. Shafer
The Journal of infectious diseases, ISSN 0022-1899, 5/2009, Volume 199, Issue 9, pp. 1275 - 1285
Polymerase chain reaction | Error rates | DNA | Viruses | Stop codon | Genomes | Hepatitis B virus | Genetic mutation | Sequencing | Genotypes | Fundamental and applied biological sciences. Psychology | Miscellaneous | Infectious diseases | Microbiology | Biological and medical sciences | Medical sciences | Virology | Humans | DNA, Viral - isolation & purification | Drug Resistance, Viral | Hepatitis B - virology | Genetic Variation | Hepatitis B - complications | Adenine - therapeutic use | Base Sequence | Lamivudine - therapeutic use | Polymerase Chain Reaction | Reverse Transcriptase Inhibitors - therapeutic use | RNA-Directed DNA Polymerase | Adenine - analogs & derivatives | Organophosphonates - therapeutic use | Antiviral Agents - therapeutic use | Genotype | DNA Primers | Hepatitis B virus - drug effects | HIV Infections - complications | Hepatitis B - drug therapy | Hepatitis B virus - genetics | HIV Infections - drug therapy | Hepatitis B virus - isolation & purification | Mutation | DNA, Viral - genetics | Care and treatment | Gene mutations | Nucleosides | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | Drug resistance | Hepatitis B | Index Medicus | Abridged Index Medicus
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