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nucleoside-phosphate kinase - antagonists & inhibitors (99) 99
humans (77) 77
index medicus (68) 68
nucleoside-phosphate kinase - metabolism (68) 68
animals (50) 50
biochemistry & molecular biology (46) 46
chemistry, medicinal (39) 39
models, molecular (38) 38
structure-activity relationship (35) 35
enzyme inhibitors - pharmacology (33) 33
thymidylate kinase (31) 31
mycobacterium tuberculosis - enzymology (30) 30
nucleoside-phosphate kinase - chemistry (28) 28
drug design (26) 26
kinetics (26) 26
substrate specificity (23) 23
antitubercular agents - pharmacology (22) 22
binding sites (22) 22
enzyme inhibitors - chemistry (21) 21
nucleoside-phosphate kinase - genetics (21) 21
tricyclic nucleoside phosphate (21) 21
mycobacterium tuberculosis - drug effects (20) 20
mycobacterium tuberculosis (19) 19
phosphorylation (19) 19
nucleosides (18) 18
thymidine monophosphate kinase (18) 18
crystallography, x-ray (17) 17
life sciences (17) 17
mice (17) 17
microbial sensitivity tests (17) 17
nucleoside analogs (17) 17
analysis (16) 16
enzyme inhibitors - chemical synthesis (16) 16
enzymes (16) 16
mycobacterium-tuberculosis (16) 16
thymidine - analogs & derivatives (16) 16
tuberculosis (16) 16
antitubercular agents - chemistry (15) 15
inhibitors (15) 15
molecular structure (15) 15
oncology (15) 15
pharmacology & pharmacy (15) 15
anti-bacterial agents - pharmacology (14) 14
guanylate kinases (14) 14
thymidine - pharmacology (14) 14
antitubercular agents - chemical synthesis (13) 13
nucleoside-phosphate kinase (13) 13
proto-oncogene proteins c-akt - antagonists & inhibitors (13) 13
amino acid sequence (12) 12
cancer (12) 12
cell line (12) 12
chemistry (12) 12
thymidine (12) 12
thymidine-5'-o-monophosphate analogs (12) 12
biophysics (11) 11
mechanism (11) 11
molecular sequence data (11) 11
protein binding (11) 11
protein kinase inhibitors - pharmacology (11) 11
proteins (11) 11
proto-oncogene proteins c-akt - metabolism (11) 11
signal transduction - drug effects (11) 11
akt (10) 10
antineoplastic agents - pharmacology (10) 10
enzyme inhibitors (10) 10
escherichia-coli (10) 10
anti-bacterial agents - chemistry (9) 9
cell line, tumor (9) 9
chemistry, organic (9) 9
kinase (9) 9
kinases (9) 9
ligands (9) 9
mesh : nucleoside-phosphate kinase (9) 9
microbiology (9) 9
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plasmodium falciparum - enzymology (9) 9
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thymidine - chemical synthesis (9) 9
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mesh : mycobacterium tuberculosis (8) 8
mesh : structure-activity relationship (8) 8
mutation (8) 8
nucleosides - pharmacology (8) 8
pyrimidines (8) 8
thymidine kinase - antagonists & inhibitors (8) 8
tuberculosis - drug therapy (8) 8
adenosine triphosphate - metabolism (7) 7
anti-bacterial agents - chemical synthesis (7) 7
article (7) 7
biochemistry, molecular biology (7) 7
catalytic domain (7) 7
cell biology (7) 7
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computer science, interdisciplinary applications (7) 7
crystal-structure (7) 7
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Cancer Research, ISSN 0008-5472, 07/2004, Volume 64, Issue 13, pp. 4394 - 4399
Journal Article
Oncogene, ISSN 0950-9232, 10/2007, Volume 26, Issue 49, pp. 6979 - 6988
Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary tumours towards metastasis andis likely caused by a pathological... 
Epithelial to mesenchymal transition | Transcription | Epithelial polarity | Invasion | Cell adhesion | epithelial polarity | DIFFERENTIATION PROGRAM | transcription | FACTOR SNAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-CADHERIN EXPRESSION | VITAMIN-D-RECEPTOR | BETA-CATENIN | CELL BIOLOGY | BREAST-CANCER | COLON-CANCER | LUNG-CANCER | invasion | ONCOLOGY | cell adhesion | MESENCHYMAL TRANSITIONS | GENETICS & HEREDITY | epithelial to mesenchymal transition | PROGRESSION | Cell Polarity | Colonic Neoplasms - genetics | Nucleoside-Phosphate Kinase - genetics | Cadherins - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Middle Aged | Immunoblotting | Gene Expression Profiling | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Chromatin Immunoprecipitation | Neoplasm Invasiveness - pathology | Adult | Cytoskeletal Proteins - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Tumor Cells, Cultured | Snail Family Transcription Factors | Promoter Regions, Genetic | Epithelium - pathology | Epithelium - metabolism | Membrane Proteins - genetics | Down-Regulation | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Membrane Proteins - antagonists & inhibitors | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Aged | Microscopy, Fluorescence | Nucleoside-Phosphate Kinase - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Cancer cells | Physiological aspects | Genetic aspects | Research | DNA binding proteins | Health aspects | Proteins | Oncology | Gene expression | Colorectal cancer | Cell adhesion & migration | Tumors
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2281 - 2291
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially... 
TARGET | NATURAL-PRODUCT | THYMIDYLATE KINASE | BIOSYNTHESIS | ESCHERICHIA-COLI | ALANINE LIGASE | D-CYCLOSERINE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | MASS-SPECTROMETRY | PATHOGENS | Acyltransferases - antagonists & inhibitors | Metabolomics | Nucleoside-Phosphate Kinase - genetics | Ceftazidime - pharmacology | Escherichia coli - drug effects | Humans | Triclosan - metabolism | Triclosan - pharmacology | Acyltransferases - metabolism | Threonine - metabolism | Acyltransferases - genetics | Fosfomycin - metabolism | Pyrimidines - metabolism | DNA, Bacterial - antagonists & inhibitors | Ceftazidime - metabolism | Cell Wall - drug effects | Terpenes - antagonists & inhibitors | Terpenes - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Mass Spectrometry | Escherichia coli - metabolism | HEK293 Cells | Chromatography, Liquid | Hydroxamic Acids - pharmacology | Fosfomycin - analogs & derivatives | Carbonyl Cyanide m-Chlorophenyl Hydrazone - metabolism | Gene Expression | DNA, Bacterial - biosynthesis | Fosfomycin - pharmacology | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Adenosine - pharmacology | Cell Wall - chemistry | Pyrimidines - pharmacology | Threonine - analogs & derivatives | Hydroxamic Acids - metabolism | Threonine - pharmacology | Metabolome - drug effects | Escherichia coli - genetics | Cell Wall - metabolism | Adenosine - metabolism | Anti-Bacterial Agents - pharmacology | Nucleoside-Phosphate Kinase - metabolism
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Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 11, pp. 4584 - 4597
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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2011, Volume 54, Issue 1, pp. 222 - 232
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 24, pp. 10948 - 10957
Journal Article
Journal of Bioenergetics and Biomembranes, ISSN 0145-479X, 10/2015, Volume 47, Issue 5, pp. 431 - 440
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5172 - 5182
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2007, Volume 50, Issue 22, pp. 5281 - 5292
Journal Article