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nucleoside-phosphate kinase - metabolism (548) 548
animals (381) 381
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biochemistry & molecular biology (261) 261
guanylate kinases (255) 255
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molecular sequence data (197) 197
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thymidylate kinase (56) 56
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recombinant proteins - metabolism (44) 44
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adenosine triphosphate - metabolism (42) 42
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thymidine kinase - metabolism (42) 42
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disks large homolog 4 protein (33) 33
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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2281 - 2291
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially... 
TARGET | NATURAL-PRODUCT | THYMIDYLATE KINASE | BIOSYNTHESIS | ESCHERICHIA-COLI | ALANINE LIGASE | D-CYCLOSERINE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | MASS-SPECTROMETRY | PATHOGENS | Acyltransferases - antagonists & inhibitors | Metabolomics | Nucleoside-Phosphate Kinase - genetics | Ceftazidime - pharmacology | Escherichia coli - drug effects | Humans | Triclosan - metabolism | Triclosan - pharmacology | Acyltransferases - metabolism | Threonine - metabolism | Acyltransferases - genetics | Fosfomycin - metabolism | Pyrimidines - metabolism | DNA, Bacterial - antagonists & inhibitors | Ceftazidime - metabolism | Cell Wall - drug effects | Terpenes - antagonists & inhibitors | Terpenes - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Mass Spectrometry | Escherichia coli - metabolism | HEK293 Cells | Chromatography, Liquid | Hydroxamic Acids - pharmacology | Fosfomycin - analogs & derivatives | Carbonyl Cyanide m-Chlorophenyl Hydrazone - metabolism | Gene Expression | DNA, Bacterial - biosynthesis | Fosfomycin - pharmacology | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Adenosine - pharmacology | Cell Wall - chemistry | Pyrimidines - pharmacology | Threonine - analogs & derivatives | Hydroxamic Acids - metabolism | Threonine - pharmacology | Metabolome - drug effects | Escherichia coli - genetics | Cell Wall - metabolism | Adenosine - metabolism | Anti-Bacterial Agents - pharmacology | Nucleoside-Phosphate Kinase - metabolism
Journal Article
Oncogene, ISSN 0950-9232, 10/2007, Volume 26, Issue 49, pp. 6979 - 6988
Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary tumours towards metastasis andis likely caused by a pathological... 
Epithelial to mesenchymal transition | Transcription | Epithelial polarity | Invasion | Cell adhesion | epithelial polarity | DIFFERENTIATION PROGRAM | transcription | FACTOR SNAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-CADHERIN EXPRESSION | VITAMIN-D-RECEPTOR | BETA-CATENIN | CELL BIOLOGY | BREAST-CANCER | COLON-CANCER | LUNG-CANCER | invasion | ONCOLOGY | cell adhesion | MESENCHYMAL TRANSITIONS | GENETICS & HEREDITY | epithelial to mesenchymal transition | PROGRESSION | Cell Polarity | Colonic Neoplasms - genetics | Nucleoside-Phosphate Kinase - genetics | Cadherins - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Middle Aged | Immunoblotting | Gene Expression Profiling | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Chromatin Immunoprecipitation | Neoplasm Invasiveness - pathology | Adult | Cytoskeletal Proteins - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Tumor Cells, Cultured | Snail Family Transcription Factors | Promoter Regions, Genetic | Epithelium - pathology | Epithelium - metabolism | Membrane Proteins - genetics | Down-Regulation | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Membrane Proteins - antagonists & inhibitors | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Aged | Microscopy, Fluorescence | Nucleoside-Phosphate Kinase - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Cancer cells | Physiological aspects | Genetic aspects | Research | DNA binding proteins | Health aspects | Proteins | Oncology | Gene expression | Colorectal cancer | Cell adhesion & migration | Tumors
Journal Article
Cancer Discovery, ISSN 2159-8274, 08/2013, Volume 3, Issue 8, pp. 870 - 879
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2527 - 2544
Thymidylate kinase (TMK) is a key enzyme which plays an important role in DNA synthesis. It belongs to the family of nucleoside monophosphate kinases, several... 
active site dynamics | transition state | associative phosphoryl transfer | thymidylate kinase | random bi‐bi mechanism | random bi-bi mechanism | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | CRYSTALLOGRAPHY | MONOPHOSPHATE KINASE | GENERAL-PROPERTIES | ADENYLATE KINASE | EFFICIENT PHOSPHORYLATION | GUANYLATE KINASE | KINETIC-ANALYSIS | PROTEINS | BINDING | Nucleoside-Phosphate Kinase - genetics | Ribonucleotides - chemistry | Bacterial Proteins - chemistry | Substrate Specificity | Crystallography, X-Ray | Holoenzymes - chemistry | Holoenzymes - metabolism | Nucleoside-Phosphate Kinase - chemistry | Apoenzymes - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Ribonucleotides - metabolism | Biocatalysis | Mutagenesis, Site-Directed | Bacterial Proteins - genetics | Enzyme Stability | Models, Molecular | Recombinant Proteins - chemistry | Bacteria, Thermoduric - enzymology | Sequence Alignment | Apoenzymes - genetics | Apoenzymes - chemistry | Bacterial Proteins - metabolism | Ligands | Protein Conformation | Holoenzymes - genetics | Mutation | Amino Acid Substitution | Nucleoside-Phosphate Kinase - metabolism | Enzymes | DNA synthesis | Nucleotides | Catalysis | Analysis | Phosphates | X-ray diffraction | Homology | Kinases | Mutants | Intermediates | DNA biosynthesis | Diffraction | Mutagenesis | Arginine | Coding | Site-directed mutagenesis | Dimensional changes | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 8383 - 8394
The Akt pathway is frequently hyperactivated in human cancer and functions as a cardinal nodal point for transducing extracellular and intracellular oncogenic... 
CANCER-CELLS | PHASE-II TRIAL | TRICYCLIC NUCLEOSIDE PHOSPHATE | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | PLECKSTRIN HOMOLOGY DOMAIN | RAC PROTEIN-KINASE | SELECTIVE INHIBITORS | ANTITUMOR-ACTIVITY | AKT/PROTEIN KINASE-B | NIH 3T3 Cells | Neoplasm Transplantation | Pancreatic Neoplasms - metabolism | Humans | Ovarian Neoplasms - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Pancreatic Neoplasms - drug therapy | Immediate-Early Proteins - metabolism | Protein Kinase C - metabolism | Nucleosides - pharmacology | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Ovarian Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | STAT3 Transcription Factor - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Nucleosides - chemistry | Pancreatic Neoplasms - pathology | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Signal Transduction - physiology | Mice | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Signal Transduction | PI 3-Kinase | Phosphatidylinositol-dependent Kinase-1 (PDK1) | mTOR | Tumor | Inhibitor | Akt PKB
Journal Article
Photosynthesis Research, ISSN 0166-8595, 7/2018, Volume 137, Issue 1, pp. 53 - 67
Journal Article