X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (23885) 23885
Publication (3091) 3091
Patent (1298) 1298
Newsletter (225) 225
Book Chapter (214) 214
Book Review (193) 193
Book / eBook (59) 59
Conference Proceeding (47) 47
Dissertation (24) 24
Newspaper Article (7) 7
Data Set (6) 6
Magazine Article (4) 4
Reference (3) 3
Web Resource (2) 2
Government Document (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (10298) 10298
humans (9764) 9764
nucleosides (6593) 6593
index medicus (5781) 5781
biochemistry & molecular biology (5230) 5230
nucleotides (3414) 3414
kinetics (3250) 3250
male (3239) 3239
nucleosides - metabolism (3073) 3073
mice (2970) 2970
rats (2936) 2936
female (2773) 2773
pharmacology & pharmacy (2160) 2160
nucleic acids (1983) 1983
chemistry (1961) 1961
research (1902) 1902
metabolism (1788) 1788
enzymes (1775) 1775
molecular sequence data (1767) 1767
dna (1703) 1703
microbiology (1702) 1702
cell line (1639) 1639
biochemistry (1527) 1527
organic chemistry (1503) 1503
proteins (1471) 1471
nucleosides - pharmacology (1469) 1469
sugars (1437) 1437
tritium (1375) 1375
oncology (1346) 1346
cell biology (1338) 1338
analysis (1335) 1335
amino acid sequence (1334) 1334
nucleotides - metabolism (1331) 1331
derivatives thereof (1298) 1298
metallurgy (1298) 1298
substrate specificity (1289) 1289
mutation (1272) 1272
heterocyclic compounds (1234) 1234
phosphorylation (1224) 1224
in vitro techniques (1207) 1207
adenosine (1203) 1203
article (1194) 1194
base sequence (1180) 1180
expression (1180) 1180
models, molecular (1175) 1175
cells, cultured (1167) 1167
cells (1160) 1160
rna (1153) 1153
binding sites (1126) 1126
pyrimidines (1120) 1120
nucleoside analogs (1106) 1106
escherichia-coli (1089) 1089
chemistry, medicinal (1084) 1084
physiological aspects (1083) 1083
thymidine (1077) 1077
structure-activity relationship (1072) 1072
cancer (1042) 1042
adult (1037) 1037
adenosine triphosphate - metabolism (1022) 1022
time factors (1021) 1021
research article (988) 988
nucleoside (956) 956
thymidine - metabolism (954) 954
adenosine - metabolism (948) 948
human necessities (947) 947
middle aged (947) 947
cell line, tumor (934) 934
nucleosides - chemistry (921) 921
organic compounds (899) 899
dna - metabolism (871) 871
protein binding (871) 871
purine-nucleoside phosphorylase - metabolism (867) 867
culture media (865) 865
biophysics (847) 847
molecular structure (836) 836
carbon isotopes (828) 828
organic nitrogen compounds (817) 817
ribosides (814) 814
gene expression (808) 808
hygiene (805) 805
medical or veterinary science (805) 805
multidisciplinary sciences (801) 801
preparations for medical, dental, or toilet purposes (794) 794
dose-response relationship, drug (778) 778
enzymology (773) 773
hydrogen-ion concentration (751) 751
antiviral agents - pharmacology (722) 722
nucleoside diphosphate sugars - metabolism (712) 712
chemistry, organic (711) 711
protein (705) 705
nucleoside diphosphate kinase (703) 703
nucleoside-diphosphate kinase - metabolism (703) 703
inhibition (702) 702
azines (689) 689
basic biological sciences (689) 689
liver - metabolism (686) 686
beer (684) 684
crystal-structure (683) 683
wine (682) 682
mutation or genetic engineering (681) 681
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (37) 37
Chemistry (A D Allen) - Stacks (8) 8
UofT at Mississauga - Stacks (7) 7
UTL at Downsview - May be requested (4) 4
Collection Dvlpm't (Acquisitions) - Closed Orders (3) 3
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
Online Resources - Online (3) 3
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Gerstein Science - Circulation Desk (1) 1
Gerstein Science - Theses (1) 1
University Archives - Archives (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (24532) 24532
French (428) 428
German (364) 364
Chinese (217) 217
Russian (198) 198
Japanese (111) 111
Italian (82) 82
Spanish (63) 63
Polish (31) 31
Korean (28) 28
Portuguese (27) 27
Ukrainian (14) 14
Norwegian (10) 10
Slovak (9) 9
Czech (5) 5
Hungarian (5) 5
Danish (4) 4
Dutch (3) 3
Romanian (3) 3
Croatian (2) 2
Finnish (2) 2
Greek (2) 2
Slovenian (2) 2
Swedish (2) 2
Turkish (2) 2
Hebrew (1) 1
Lithuanian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Journal Article
1973, ISBN 9780123405500, xviii, 304
Book
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 192 - 197
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CFT1A, a rate-limiting enzyme of... 
OXIDATION | DISTRIBUTIONS | GLYCOLYSIS | REDUCTIVE GLUTAMINE-METABOLISM | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | TUMOR | PROLIFERATION | GROWTH-FACTOR | CANCER | CULTURE | Carnitine O-Palmitoyltransferase - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Neovascularization, Pathologic - pathology | Nucleotides - chemistry | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Carnitine O-Palmitoyltransferase - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Nucleotides - biosynthesis | Nucleotides - pharmacology | Oxidation-Reduction - drug effects | DNA - biosynthesis | Carnitine O-Palmitoyltransferase - deficiency | Fatty Acids - metabolism | Disease Models, Animal | Carbon - metabolism | Fatty Acids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | Gene Silencing | Acetic Acid - pharmacology | Blood Vessels - cytology | Citric Acid Cycle | Animals | Retinopathy of Prematurity - drug therapy | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Cell Line, Tumor | Glucose - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Retinopathy of Prematurity - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Retinopathy of Prematurity - pathology | Physiological aspects | Deoxyribonucleotides | Fatty acids | Carbon | Endothelium | Proteins | Angiogenesis | Protein synthesis | Glucose | Kinases | Deoxyribonucleic acid--DNA | Cells
Journal Article
Journal of Cell Science, ISSN 0021-9533, 03/2005, Volume 118, Issue 6, pp. 1267 - 1277
Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals of... 
Axon | Necl-1 | Glia | Myelin | Nectin | Schwann cell | myelin | TUMOR-SUPPRESSOR TSLC1 | ADHERENS JUNCTION | LOCALIZATION | PROTEIN | DEVELOPING MOUSE | AFADIN | glia | CELL BIOLOGY | LUNG-CANCER | EPITHELIAL-CELLS | GENE | axon | nectin | HUMAN HOMOLOG | Immunohistochemistry | Immunoglobulins - physiology | Cadherins - metabolism | Calcium - metabolism | Humans | Calcium - chemistry | Brain - metabolism | Immunoglobulins - metabolism | Tissue Distribution | Cell Adhesion Molecule-1 | Time Factors | Membrane Proteins - physiology | Antigens, Neoplasm - metabolism | Neurons - metabolism | Dimerization | Silver Staining | Schwann Cells - metabolism | Cell Adhesion | Cell Adhesion Molecules - metabolism | Plasmids - metabolism | Blotting, Western | Guanylate Kinases | Mice | Nucleoside-Phosphate Kinase - metabolism | Immunoprecipitation | Exons | Actins - metabolism | Cytoplasm - metabolism | Neoplasm Proteins - metabolism | Microscopy, Immunoelectron | Myelin Sheath - metabolism | Membrane Proteins - metabolism | Protein Structure, Tertiary | Cell Line | Gene Library | Cerebellum - metabolism | Electrophoresis, Polyacrylamide Gel | Axons - metabolism | Cell Communication | Nuclear Proteins - metabolism | Transcription Factors - metabolism | Hippocampus - metabolism | Two-Hybrid System Techniques | Animals | Presynaptic Terminals - metabolism | Protein Binding | Neuroglia - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Microscopy, Fluorescence | Tumor Suppressor Proteins
Journal Article
Head & Neck, ISSN 1043-3074, 10/2011, Volume 33, Issue 10, pp. 1458 - 1466
Background We evaluated the predictive significance of 14 reported markers using immunohistochemical study in nasopharyngeal carcinoma. Methods... 
prognostic biomolecular markers | radiotherapy | combined score | nasopharyngeal carcinoma | immunohistochemical staining | SURVIVAL | SURGERY | SYNDECAN-1 EXPRESSION | CHEMORADIOTHERAPY | TUMOR ANGIOGENESIS | CANCER | CHEMOTHERAPY | GROWTH-FACTOR RECEPTOR | ADVANCED-STAGE | OTORHINOLARYNGOLOGY | PROTEIN EXPRESSION | DIFFERENTIATION | Immunohistochemistry | Proto-Oncogene Proteins c-met - metabolism | Nasopharyngeal Neoplasms - metabolism | Nasopharyngeal Neoplasms - mortality | Prognosis | Follow-Up Studies | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Carcinoma - mortality | Male | NM23 Nucleoside Diphosphate Kinases - metabolism | STAT5 Transcription Factor - metabolism | Receptor, Epidermal Growth Factor - metabolism | Biomarkers, Tumor - metabolism | Adult | Female | Chemotherapy, Adjuvant | STAT3 Transcription Factor - metabolism | Cellular Apoptosis Susceptibility Protein - metabolism | Tumor Suppressor Proteins - metabolism | Syndecan-1 - metabolism | Nasopharyngeal Neoplasms - therapy | Tumor Suppressor Protein p53 - metabolism | Cathepsin D - metabolism | Transcription Factors - metabolism | Disease-Free Survival | Cyclooxygenase 2 - metabolism | Carcinoma - therapy | Aged | Carcinoma - metabolism | Early Growth Response Protein 1 - metabolism | RNA-Binding Proteins - metabolism | Radiotherapy, Intensity-Modulated
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2281 - 2291
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially... 
TARGET | NATURAL-PRODUCT | THYMIDYLATE KINASE | BIOSYNTHESIS | ESCHERICHIA-COLI | ALANINE LIGASE | D-CYCLOSERINE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | MASS-SPECTROMETRY | PATHOGENS | Acyltransferases - antagonists & inhibitors | Metabolomics | Nucleoside-Phosphate Kinase - genetics | Ceftazidime - pharmacology | Escherichia coli - drug effects | Humans | Triclosan - metabolism | Triclosan - pharmacology | Acyltransferases - metabolism | Threonine - metabolism | Acyltransferases - genetics | Fosfomycin - metabolism | Pyrimidines - metabolism | DNA, Bacterial - antagonists & inhibitors | Ceftazidime - metabolism | Cell Wall - drug effects | Terpenes - antagonists & inhibitors | Terpenes - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Mass Spectrometry | Escherichia coli - metabolism | HEK293 Cells | Chromatography, Liquid | Hydroxamic Acids - pharmacology | Fosfomycin - analogs & derivatives | Carbonyl Cyanide m-Chlorophenyl Hydrazone - metabolism | Gene Expression | DNA, Bacterial - biosynthesis | Fosfomycin - pharmacology | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Adenosine - pharmacology | Cell Wall - chemistry | Pyrimidines - pharmacology | Threonine - analogs & derivatives | Hydroxamic Acids - metabolism | Threonine - pharmacology | Metabolome - drug effects | Escherichia coli - genetics | Cell Wall - metabolism | Adenosine - metabolism | Anti-Bacterial Agents - pharmacology | Nucleoside-Phosphate Kinase - metabolism
Journal Article
Digestive and Liver Disease, ISSN 1590-8658, 2015, Volume 48, Issue 3, pp. 223 - 230
Abstract Pancreatic ductal adenocarcinoma is characterized by a poor prognosis and a low median survival, despite improvements observed for many other solid... 
Gastroenterology and Hepatology | Chemotherapy | Prognostic marker | Metastatic pancreatic cancer | Predictive marker | BRCA2 MUTATIONS | TUMOR-SUPPRESSOR GENE | CANCER | INVASIVE DUCTAL CARCINOMA | CIGARETTE-SMOKING | INCREASED RISK | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1 | GASTROENTEROLOGY & HEPATOLOGY | GEMCITABINE TRANSPORT | SPARC EXPRESSION | CLINICAL-OUTCOMES | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Prognosis | Humans | Carcinoma, Pancreatic Ductal - metabolism | Neoplasm Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Neoplasm Metastasis | Adenocarcinoma - metabolism | Matrix Metalloproteinase 7 - metabolism | Biomarkers, Tumor - metabolism | Microfilament Proteins - metabolism | Calcium-Binding Proteins - metabolism | Mucin-4 - metabolism | Pancreatic Neoplasms - pathology | Osteonectin - metabolism | Treatment Outcome | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | CA-19-9 Antigen - metabolism | Carrier Proteins - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mucin 5AC - metabolism | Growth Differentiation Factor 15 - metabolism | Adenocarcinoma | Leucovorin | Metastasis | Pancreatic cancer | Cancer | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Organic chemistry | Chemical Sciences
Journal Article