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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 07/2018, Volume 14, Issue 7, p. e1006317
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Organic chemistry | Chemical Sciences
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 758 - 765
OBJECTIVE—Diet-induced obesity (DIO) in mice causes vascular inflammation and insulin resistance that are accompanied by decreased endothelial-derived NO... 
ENOS | Nitric oxide | Vascular inflammation | nitric oxide | eNOS | ACTIVATED PROTEIN-KINASE | SILDENAFIL | IKK-BETA | ALPHA | ADHESION MOLECULES | NITRIC-OXIDE PRODUCTION | INHIBITION | ENDOTHELIAL-CELLS | vascular inflammation | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | EXPRESSION | Humans | Phosphodiesterase 5 Inhibitors | Male | NF-kappa B - metabolism | Insulin Receptor Substrate Proteins - metabolism | Aortic Diseases - metabolism | Sildenafil Citrate | Inflammation - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Endothelial Cells - metabolism | Down-Regulation | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Cell Adhesion Molecules - metabolism | Inflammation - etiology | Nitric Oxide Synthase Type III - genetics | Piperazines - pharmacology | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Insulin - metabolism | Cyclic GMP - metabolism | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Endothelial Cells - enzymology | Palmitic Acid - metabolism | Phosphorylation | Phosphatidylinositol 3-Kinases - metabolism | Sulfones - pharmacology | I-kappa B Kinase - metabolism | Dietary Fats | Inflammation Mediators - metabolism | Aorta, Thoracic - drug effects | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type III - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Purines - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Insulin Resistance | Phosphodiesterase Inhibitors - pharmacology | Aorta, Thoracic - physiopathology | Aortic Diseases - physiopathology | Animals | Nitric Oxide - metabolism | Aortic Diseases - etiology | Endothelial Cells - drug effects | Inflammation - physiopathology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9800 - 9805
When macroautophagy, a catabolic process that rids the cells of unwanted proteins, is initiated, 30-60 nm Atg9 vesicles move from the Golgi to the... 
Proteins | Spheroplasts | Yeasts | Gels | Biological transport | Antibodies | HeLa cells | Physiological regulation | Nitrogen | Goods and services tax | Membrane tethering | GEF | PRE-AUTOPHAGOSOMAL STRUCTURE | COMPLEX | VESICLES | PROTEIN-KINASE | MEMBRANE | MULTIDISCIPLINARY SCIENCES | membrane tethering | GOLGI | INDUCTION | ORGANIZATION | TRAPPII | MUTANTS | Protein Kinases - metabolism | NIH 3T3 Cells | Autophagy-Related Proteins | Protein Kinases - genetics | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | Humans | Cercopithecus aethiops | Immunoblotting | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Autophagy-Related Protein-1 Homolog | Saccharomyces cerevisiae - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | rab GTP-Binding Proteins - metabolism | Green Fluorescent Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | rab1 GTP-Binding Proteins - metabolism | Membrane Proteins - genetics | Phagosomes - metabolism | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | rab1 GTP-Binding Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Golgi Apparatus - metabolism | Mice | HeLa Cells | COS Cells | Microscopy, Fluorescence | Autophagy (Cytology) | Research | Properties | Phosphotransferases | Golgi apparatus | Biological Sciences
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7629, pp. 390 - 395
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 760 - 768
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, p. 40648
Journal Article
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Kristiansson, Kati and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Stančáková, Alena and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and van Vliet-Ostaptchouk, Jana V and Yengo, Loïc and Zhang, Weihua and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Böhringer, Stefan and Bonnet, Fabrice and Böttcher, Yvonne and Bruinenberg, Marcel and Carba, Delia B and Caspersen, Ida H and Clarke, Robert and Daw, E. Warwick and Deelen, Joris and Deelman, Ewa and Delgado, Graciela and Doney, Alex S. F and Eklund, Niina and Erdos, Michael R and Estrada, Karol and Eury, Elodie and Frieich, Nele and Garcia, Melissa E and Gieaitis, Vilmantas and Gigante, Bruna and Go, Alan S and Golay, Alain and Grallert, Harald and Grammer, Tanja B and Gräßler, Jürgen and Grewal, Jagvir and Groves, Christopher J and Haller, Toomas and Hallmans, Goran and ... and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
Journal Article