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Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 243 - 245
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 4, pp. e1003989 - e1003989
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to... 
DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | KAPPA-B KINASE | COMPLEX CLASS-II | DEPENDENT PROTEIN-KINASE | MICROBIOLOGY | ANTIGEN PRESENTATION | INTERFERON INDUCTION | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | INNATE IMMUNE SENSOR | PARASITOLOGY | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Index Medicus | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
Brain, ISSN 0006-8950, 2011, Volume 134, Issue 3, pp. 678 - 692
Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free... 
oral therapy | transcription factor | autoimmune demyelination | multiple sclerosis | neuroprotection | astrocyte | oxidative stress | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ENZYME INDUCERS | DIMETHYLFUMARATE | SPINAL-CORD | NEUROSCIENCES | HUMAN ENDOTHELIAL-CELLS | CLINICAL NEUROLOGY | RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | MULTIPLE-SCLEROSIS | IN-VIVO | Embryo, Mammalian | Antioxidants - metabolism | Humans | Green Fluorescent Proteins - genetics | Neuroprotective Agents - pharmacology | Time Factors | Statistics, Nonparametric | Aldehyde Reductase - metabolism | Nogo Proteins | Sleep - physiology | Tandem Mass Spectrometry - methods | Disease Models, Animal | Fumarates - therapeutic use | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins - adverse effects | CD3 Complex - metabolism | Motor Neurons - metabolism | Signal Transduction - drug effects | Axons - pathology | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Peptide Fragments - adverse effects | Oxidative Stress - drug effects | Myelin Proteins - metabolism | Neuroprotective Agents - therapeutic use | Chromatography, High Pressure Liquid - methods | Encephalomyelitis, Autoimmune, Experimental - etiology | Transfection | Astrocytes - immunology | Mass Spectrometry | Motor Neurons - cytology | Antigens, Differentiation - metabolism | Female | Spinal Cord - cytology | Motor Neurons - drug effects | Multiple Sclerosis - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Axons - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Gene Expression Regulation - drug effects | Animals | Multiple Sclerosis - pathology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2004, Volume 167, Issue 2, pp. 327 - 337
Front-rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which... 
T lymphocytes | Phosphorylation | Lymphocytes | Cell lines | Polar caps | Schwann cells | Actins | Cell membranes | Cytoplasm | Cells | ACTIVATION | GTPASES | EZRIN | CELL-MIGRATION | TRANSENDOTHELIAL MIGRATION | MEMBRANE | IN-VIVO | EZRIN/RADIXIN/MOESIN PROTEINS | T-LYMPHOCYTES | FAMILY | CELL BIOLOGY | Immunoprecipitation | Actins - metabolism | Cytoplasm - metabolism | rhoA GTP-Binding Protein - metabolism | Blood Proteins - metabolism | Phosphoproteins - metabolism | Lymphoma, T-Cell - metabolism | Cell Nucleus - metabolism | Transfection | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | rho-Associated Kinases | Hyaluronan Receptors - metabolism | Cytoskeletal Proteins - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | Lymphocytes - metabolism | Protein Structure, Tertiary | Green Fluorescent Proteins - metabolism | Signal Transduction | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Hyaluronan Receptors - biosynthesis | Chemotaxis | Plasmids - metabolism | Blotting, Western | Animals | Models, Biological | Cell Line, Tumor | Cytoskeleton - metabolism | Mice | Pyridines - pharmacology | Enzyme Activation | Microscopy, Fluorescence | Cell Movement | Cytology | Research | Proteins | Plasma | Enzymes | Membranes | Cellular biology | Cytoskeleton | Cell adhesion & migration | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 493 - 498
Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here... 
CADHERIN SUPERFAMILY | LUNG | EXPRESSION ANALYSIS | CONNEXIN | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | GENES | CYTOSOLIC DNA | CLASSIFICATION | TUMOR-CELLS | RAT-BRAIN | Meclofenamic Acid - pharmacology | Meclofenamic Acid - therapeutic use | Nucleotides, Cyclic - metabolism | Gap Junctions - metabolism | Benzopyrans - therapeutic use | Cadherins - metabolism | Coculture Techniques | Humans | Brain Neoplasms - pathology | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | NF-kappa B - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - secondary | STAT1 Transcription Factor - metabolism | Benzamides - therapeutic use | Female | Benzamides - pharmacology | Membrane Proteins - metabolism | Benzopyrans - pharmacology | Astrocytes - cytology | Astrocytes - drug effects | Interferon-alpha - metabolism | Connexin 43 - metabolism | Tumor Necrosis Factors - metabolism | Brain Neoplasms - drug therapy | Immunity, Innate | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Paracrine Communication - drug effects | Cell Line, Tumor | Mice | Gap Junctions - drug effects | Astrocytes - metabolism | Astrocytes | Brain cancer | Physiological aspects | Metastasis | Observations | Adenylic acid | Health aspects | Proteins | Brain | Cytokines | Cells | Tumors | Cancer | Index Medicus
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 02/2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth. We evaluated... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2014, Volume 346, Issue 6210, pp. 716 - 716
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 72 - 77
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2012, Volume 32, Issue 17, pp. 6000 - 6013
The extracellular levels of excitatory amino acids are kept low by the action of the glutamate transporters. Glutamate/aspartate transporter ( GLAST) and... 
MOLECULAR-MECHANISM | RAT CEREBRAL-CORTEX |