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The New England Journal of Medicine, ISSN 0028-4793, 04/2014, Volume 370, Issue 16, pp. 1483 - 1493
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 03/2010, Volume 30, Issue 5, pp. 1217 - 1230
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2019, Volume 20, Issue 1, pp. 18 - 28
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding... 
SYNTHASE | 2ND-MESSENGER | CYCLIC GMP-AMP | IFI16 | GROWTH | INNATE IMMUNE SENSOR | IMMUNOLOGY | Neuroprotective Agents - therapeutic use | RNA Helicases - metabolism | Autoantigens - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Cytosol - immunology | Humans | Poly-ADP-Ribose Binding Proteins - antagonists & inhibitors | Multiprotein Complexes - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Catechin - therapeutic use | RNA Helicases - genetics | RNA Recognition Motif Proteins - antagonists & inhibitors | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | RNA Recognition Motif Proteins - metabolism | DNA Helicases - genetics | Disease Models, Animal | DNA - immunology | Poly-ADP-Ribose Binding Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Autoimmune Diseases of the Nervous System - drug therapy | RNA Helicases - antagonists & inhibitors | Mice, Knockout | DNA Helicases - metabolism | Animals | Autoantigens - immunology | Interferons - metabolism | Nervous System Malformations - drug therapy | Protein Binding | Cytosol - metabolism | Catechin - analogs & derivatives | Mice | RNA Recognition Motif Proteins - genetics | DNA Helicases - antagonists & inhibitors | HeLa Cells | Promoters (Genetics) | Research | DNA-ligand interactions | Transferases | AMP | Therapeutic applications | Medical treatment | Epigallocatechin-3-gallate | Activation | Gene expression | Proteins | Epigallocatechin gallate | GTPase-activating protein | Cyclic GMP | Interferon | Inhibition | Autoimmune diseases | Deoxyribonucleic acid--DNA | Guanosinetriphosphatase
Journal Article
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7729, pp. 131 - 136
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP-AMP synthase (cGAS)... 
CELLS | CYCLIC GMP-AMP | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | CYTOSOLIC DNA | HISTONE H2AX | HOMOLOGOUS RECOMBINATION | PARP-1 | CANCER | Neoplasms - metabolism | Phosphorylation | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | Cell Cycle Proteins - antagonists & inhibitors | Nucleotidyltransferases - deficiency | Cell Nucleus - metabolism | Neoplasms - genetics | Protein Binding - drug effects | HEK293 Cells | src-Family Kinases - metabolism | Adult | Female | Membrane Proteins - metabolism | Active Transport, Cell Nucleus | Nucleotidyltransferases - metabolism | Recombinational DNA Repair - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Animals | Cell Line, Tumor | Mice | DNA Damage | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cellular signal transduction | Research | Carcinogenesis | DNA repair | Transferases | Animal models | Homologous recombination | DNA damage | Lung cancer | Poly(ADP-ribose) | Homology | Innate immunity | Genomes | Kinases | ADP | Immunity | Cancer therapies | Genomic instability | Proteins | Ribose | Cyclic GMP | Cell cycle | Fibroblasts | Tumorigenesis | Localization | Repair | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Translocation | Stability | AMP | Nuclear transport | Poly(ADP-ribose) Polymerase 1 | Interferon regulatory factor 3 | Micronuclei | Instability | Interferon | Tumors | Cancer | Apoptosis
Journal Article
Cell, ISSN 0092-8674, 09/2018, Volume 174, Issue 6, pp. 1537 - 1548.e29
Journal Article
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7451 - 7461
Journal Article
ISSN 2050-084X, 2016
In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is... 
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 830 - 836
Journal Article