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Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
SYNTHASE | CYCLIC GMP-AMP | MAVS | PROTEIN | ROLES | MULTIDISCIPLINARY SCIENCES | ADAPTER | SENSOR | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental
Journal Article
PLoS pathogens, ISSN 1553-7374, 2014, Volume 10, Issue 4, p. e1003989
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to... 
DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | KAPPA-B KINASE | COMPLEX CLASS-II | DEPENDENT PROTEIN-KINASE | MICROBIOLOGY | ANTIGEN PRESENTATION | INTERFERON INDUCTION | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | INNATE IMMUNE SENSOR | PARASITOLOGY | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
The Plant journal : for cell and molecular biology, ISSN 1365-313X, 2003, Volume 35, Issue 2, pp. 193 - 205
... of their development, biotrophic pathogens do not kill plant cells, but rather subvert the host metabolism to favor their own growth. In contrast, necrotrophic pathogens need... 
defense response | salicylic acid | plant–pathogen interaction | Botrytis cinerea | Arabidopsis | camalexin | Plant-pathogen interaction | Camalexin | Salicylic acid | Defense response | ESSENTIAL COMPONENT | FUNGAL PATHOGENS | PHYTOALEXIN-DEFICIENT MUTANTS | PLANT DEFENSIN GENE | INDUCTION | SYSTEMIC ACQUIRED-RESISTANCE | PLANT SCIENCES | RESPONSES | ENHANCED DISEASE SUSCEPTIBILITY | METHYL JASMONATE | THALIANA | plant-pathogen interaction | Thiazoles - metabolism | Salicylic Acid - metabolism | Immunity, Innate - genetics | Cytochrome P-450 Enzyme System - metabolism | Mixed Function Oxygenases - metabolism | Plant Diseases - microbiology | Phenylalanine Ammonia-Lyase - metabolism | Oxylipins | Arabidopsis Proteins - metabolism | Indoles - metabolism | Salicylic Acid - pharmacology | Membrane Transport Proteins - genetics | Ethylenes - biosynthesis | Membrane Transport Proteins - metabolism | Plant Diseases - genetics | Carboxylic Ester Hydrolases - genetics | Plant Proteins - metabolism | Nucleotidyltransferases - metabolism | Botrytis - growth & development | Phenylalanine Ammonia-Lyase - antagonists & inhibitors | Arabidopsis Proteins - genetics | Intramolecular Transferases - genetics | Receptors, Cell Surface - metabolism | Arabidopsis - genetics | Intramolecular Transferases - metabolism | Arabidopsis - microbiology | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Phenylalanine Ammonia-Lyase - genetics | Botrytis - drug effects | Defensins | Signal Transduction - drug effects | Cytochrome P-450 Enzyme System - genetics | Nucleotidyltransferases - genetics | Cyclopentanes - metabolism | Mutation | Mixed Function Oxygenases - genetics | Carboxylic Ester Hydrolases - metabolism | Receptors, Cell Surface - genetics
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 557, Issue 7703, pp. 57 - 61
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 560, Issue 7717, pp. 238 - 242
Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic features such as a compact circular genome. Consequently, in mammals,... 
IMPORT | AICARDI-GOUTIERES-SYNDROME | READ ALIGNMENT | HUMAN GENOME | INNATE IMMUNE-RESPONSES | DNA | MULTIDISCIPLINARY SCIENCES | DISEASE | MUTATIONS | EXPRESSION | RNA Helicases - metabolism | Exoribonucleases - genetics | RNA, Mitochondrial - immunology | Exoribonucleases - deficiency | Humans | Multienzyme Complexes - metabolism | Interferon Type I - immunology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | DEAD-box RNA Helicases - deficiency | Herpesvirus 1, Human - immunology | DEAD-box RNA Helicases - metabolism | Single-Cell Analysis | Polyribonucleotide Nucleotidyltransferase - metabolism | Endoribonucleases - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Double-Stranded - immunology | Herpesvirus 1, Human - genetics | Mice | HeLa Cells | Mutation | Exoribonucleases - metabolism | Interferon Type I - antagonists & inhibitors | Physiological aspects | Mitochondrial DNA | Genetic aspects | Immune response | RNA | Immunological research | Transcription | Genes | Infections | Activation | Genomes | Accumulation | DNA helicase | Signal transduction | Mitochondria | Microorganisms | Indigenous species | Polynucleotide phosphorylase | Localization | Bioinformatics | Deoxyribonucleic acid--DNA | Immune system | Enzymes | Double-stranded RNA | RNA polymerase | Metabolism | Mammals | Ribonucleic acid--RNA | Phosphorylase | Vertebrates | Signaling | Microscopy | Interferon | Diabetes | Cytoplasm | Viral infections | RNA helicase | Life Sciences | Immunology
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 563, Issue 7729, pp. 131 - 136
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP-AMP synthase (cGAS)... 
CELLS | CYCLIC GMP-AMP | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | CYTOSOLIC DNA | HISTONE H2AX | HOMOLOGOUS RECOMBINATION | PARP-1 | CANCER | Neoplasms - metabolism | Phosphorylation | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | Cell Cycle Proteins - antagonists & inhibitors | Nucleotidyltransferases - deficiency | Cell Nucleus - metabolism | Neoplasms - genetics | Protein Binding - drug effects | HEK293 Cells | src-Family Kinases - metabolism | Adult | Female | Membrane Proteins - metabolism | Active Transport, Cell Nucleus | Nucleotidyltransferases - metabolism | Recombinational DNA Repair - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Animals | Cell Line, Tumor | Mice | DNA Damage | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cellular signal transduction | Research | Carcinogenesis | DNA repair | Transferases | Animal models | Homologous recombination | DNA damage | Lung cancer | Poly(ADP-ribose) | Homology | Innate immunity | Genomes | Kinases | Immunity | Cancer therapies | Genomic instability | Proteins | Ribose | Cyclic GMP | Cell cycle | Fibroblasts | Tumorigenesis | Localization | Repair | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Translocation | Stability | AMP | Adenosine diphosphate | Nuclear transport | Poly(ADP-ribose) Polymerase 1 | Interferon regulatory factor 3 | Micronuclei | Instability | Interferon | Tumors | Cancer | Apoptosis
Journal Article
Nucleic acids research, ISSN 0305-1048, 11/2012, Volume 40, Issue 20, pp. 10417 - 10431
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 97 - 12
.... These two activities are often present in multi-subunit complexes from nucleic acid metabolism... 
YEAST | COMPLEX | DOMAIN | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | DEGRADATION | QUATERNARY STRUCTURE | SCATTERING | FEATURES | Endoribonucleases - chemistry | RNA Helicases - metabolism | Endoribonucleases - genetics | Exoribonucleases - genetics | Saccharomyces cerevisiae - genetics | Exoribonucleases - chemistry | Multienzyme Complexes - metabolism | Crystallography, X-Ray | Mitochondrial Proteins - genetics | RNA Helicases - chemistry | RNA - genetics | Saccharomyces cerevisiae - metabolism | Mitochondrial Proteins - metabolism | Base Sequence | RNA Helicases - genetics | DEAD-box RNA Helicases - metabolism | Nucleic Acid Conformation | DEAD-box RNA Helicases - chemistry | RNA - metabolism | Amino Acid Sequence | Polyribonucleotide Nucleotidyltransferase - metabolism | Endoribonucleases - metabolism | Polyribonucleotide Nucleotidyltransferase - genetics | Multienzyme Complexes - genetics | Saccharomyces cerevisiae Proteins - genetics | RNA - chemistry | Candida glabrata - metabolism | Multienzyme Complexes - chemistry | Sequence Homology, Amino Acid | DEAD-box RNA Helicases - genetics | RNA, Mitochondrial | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Conformation | Candida glabrata - genetics | Candida glabrata - enzymology | Exoribonucleases - metabolism | Polyribonucleotide Nucleotidyltransferase - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Biodegradation | Yeast | Nucleic acids | Gene expression | Metabolism | Ribonucleic acid--RNA | DNA helicase | Mitochondria | Enzymatic activity | Nuclease | RNA processing | Crystal structure | Structural analysis
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, p. e88951
The first line of defense in plants against pathogens is induced by the recognition of microbe-associated molecular patterns (MAMP). Perception of bacterial... 
ARABIDOPSIS-THALIANA | SALICYLIC-ACID | ACID-DEPENDENT DEFENSES | MULTIDISCIPLINARY SCIENCES | PLANT DEFENSE | INNATE IMMUNE-RESPONSE | PSEUDOMONAS-SYRINGAE | BACTERIAL FLAGELLIN | ISOCHORISMATE SYNTHASE | TRANSCRIPTION FACTOR | SYSTEMIC ACQUIRED-RESISTANCE | Protein Kinases - metabolism | Arabidopsis Proteins - genetics | Protein Kinases - genetics | Intramolecular Transferases - genetics | Reactive Oxygen Species - metabolism | Salicylic Acid - metabolism | RNA, Messenger - genetics | Glucans - genetics | Gene Expression Regulation, Plant - genetics | Signal Transduction - genetics | Mutation - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Intramolecular Transferases - metabolism | Oxylipins - metabolism | Flagellin - genetics | Flagellin - metabolism | Nucleotidyltransferases - genetics | Cyclopentanes - metabolism | Glucans - metabolism | Respiratory Burst - genetics | Nucleotidyltransferases - metabolism | Arabidopsis thaliana | Physiological aspects | Defense industry | Reactive oxygen species | Transcription factors | Pathogenesis | Genes | Flagellin | Biosynthesis | mRNA | Kinases | Accumulation | Proteins | Signal transduction | Pathways | Bacteria | Pretreatment | Jasmonic acid | Deposition | Isoleucine | Pathogens | Salicylic acid | Enzymes | Plants (botany) | Coronatine | Priming | Pattern recognition | Gene expression | Signal monitoring | Mutants | Signaling | Molecular modelling | Acids | Engineering research | Genetic engineering | Bursting
Journal Article