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Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 05/2017, Volume 312, Issue 5, pp. R689 - R701
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2007, Volume 117, Issue 6, pp. 1616 - 1626
Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen... 
INACTIVATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | TRANSCRIPTION | TUMOR-SUPPRESSOR PROTEIN | FACTOR-I | HIF-1-ALPHA | O-2 HOMEOSTASIS | CARTILAGE | DELETION | Bones | Neovascularization | Research | Growth
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2005, Volume 201, Issue 1, pp. 105 - 115
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These... 
PROGRAMMED CELL-DEATH | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTITUTIVE APOPTOSIS | TUMOR-NECROSIS-FACTOR | INDUCIBLE FACTOR-1-ALPHA | PROTEIN | IMMUNOLOGY | O-2 HOMEOSTASIS | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE | HIF-ALPHA | EXPRESSION | FACTOR-ALPHA
Journal Article
Cancer Research, ISSN 0008-5472, 08/1999, Volume 59, Issue 16, pp. 3915 - 3918
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and... 
CELLS | ANGIOGENESIS | ONCOLOGY | HYPOXIA-INDUCIBLE-FACTOR-1 | TRANSCRIPTION | GENE-EXPRESSION | RECEPTOR | FACTOR-I | HIF-1-ALPHA | O-2 HOMEOSTASIS | CANCER
Journal Article
Genes and Development, ISSN 0890-9369, 11/2001, Volume 15, Issue 21, pp. 2865 - 2876
Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke. The chief... 
Cartilage | Hypoxia | hypoxia | APOPTOSIS | PHOSPHOGLYCERATE KINASE-1 | ANGIOGENESIS | INDUCIBLE FACTOR 1-ALPHA | cartilage | DEVELOPMENTAL BIOLOGY | O-2 HOMEOSTASIS | TARGET GENES | GENETICS & HEREDITY | GENE-EXPRESSION | DIFFERENTIATION | BONE | TUMOR-GROWTH | Research Paper
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 10/2001, Volume 15, Issue 20, pp. 2675 - 2686
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional... 
Histone deacetylase | Hypoxia | Corepressor | Transactivation | hypoxia | ACTIVATION | ANGIOGENESIS | INDUCIBLE FACTOR 1-ALPHA | corepressor | ALPHA | DEVELOPMENTAL BIOLOGY | O-2 HOMEOSTASIS | histone deacetylase | transactivation | UBIQUITINATION | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | EXPRESSION | BINDING | FIH-1 protein | VHL protein | proteasomes | Research Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2007, Volume 104, Issue 7, pp. 2301 - 2306
Adaptive transcriptional responses to oxygen deprivation (hypoxia) are mediated by the hypoxia-inducible factors (HIFs), heterodimeric transcription factors... 
Spleen | Messenger RNA | Anemia | Exons | Hematocrit | Small interfering RNA | Bone marrow | Hypoxia | Mice | Epics | Hypoxia-inducible factor | Red blood cell | Epo | hypoxia | EMBRYONIC-DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | HYDROXYLATION | hypoxia-inducible factor | FACTOR-I | O-2 HOMEOSTASIS | red blood cell | HEMATOPOIESIS | MICE | HIF-1-ALPHA | TUMOR-GROWTH | HIF-ALPHA | HYPOXIA-INDUCIBLE FACTOR-1 | Biological Sciences
Journal Article
by Jeong, JW and Bae, MK and Ahn, MY and Kim, SH and Sohn, TK and Bae, MH and Yoo, MA and Song, EJ and Lee, KJ and Kim, KW
CELL, ISSN 0092-8674, 11/2002, Volume 111, Issue 5, pp. 709 - 720
Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability. Recently, prolyl hydroxylation was identified... 
TRANSCRIPTION FACTOR GATA-1 | DNA-BINDING | COMPLEX | INDUCIBLE FACTOR 1-ALPHA | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TUMOR-SUPPRESSOR PROTEIN | O-2 HOMEOSTASIS | HYPOXIA | HIF-ALPHA | CELL BIOLOGY
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 06/2004, Volume 96, Issue 12, pp. 946 - 956
Background: Hypoxia-inducible factor 1 (HIF-1), a heterodimer comprising the oxygen-regulated subunit, HIF-1alpha, and HIF-1beta, mediates transcription of the... 
COLON-CANCER | FACTOR 1-ALPHA | SOLID TUMORS | ONCOLOGY | FACTOR EXPRESSION | SMOOTH-MUSCLE-CELLS | FACTOR-I | O-2 HOMEOSTASIS | UP-REGULATION | HYPOXIA-INDUCIBLE FACTOR-1 | INHIBITS TUMOR-GROWTH
Journal Article
FRONTIERS IN PLANT SCIENCE, ISSN 1664-462X, 08/2013, Volume 4
In plants, intracellular Fe trafficking must satisfy chloroplasts' and mitochondrial demands for Fe without allowing its accumulation in the organelles in... 
TRANSLOCATION | ferritin | HOMEOSTASIS | iron homeostasis | ATFER4 FERRITIN | mitochondria | CHLOROPLASTS | Cucumis sativus | roots | DEFICIENCY | PLANT SCIENCES | PROGRAMMED CELL-DEATH | CYTOCHROME-C | iron-storage protein | NITRIC-OXIDE | PLANTS | micronutrients | ARABIDOPSIS | O-2 consumption
Journal Article
JOURNAL OF BONE AND MINERAL RESEARCH, ISSN 0884-0431, 03/2012, Volume 27, Issue 3, pp. 596 - 609
Fetal growth plate cartilage is nonvascularized, and chondrocytes largely develop in hypoxic conditions. We previously found that mice lacking the... 
ENDOCHONDRAL OSSIFICATION | HIF | ANGIOGENESIS | ENDOCHONDRAL BONE-FORMATION | HYPOXIA | O-2 HOMEOSTASIS | CARTILAGE | CHONDROCYTE SURVIVAL | MULTIPLE ROLES | EPIPHYSEAL CHONDROCYTES | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | HIF-1-ALPHA | HYPOXIA-INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR | DIFFERENTIAL ROLES
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 607, Issue 1, pp. 6 - 14
Cardiomyocyte death (necrosis and apoptosis) plays a critical role in the progress of heart diseases. Salidroside, a phenylpropanoid glycoside isolated from L,... 
Salidroside | Cardiomyocyte | VEGF | Hypoxia | HIF-1α | Necrosis | Apoptosis | HIF-1 alpha | INDUCIBLE FACTOR-I | INDUCED APOPTOSIS | HEART-FAILURE | O-2-REGULATED GENE-EXPRESSION | MOUSE CARDIOMYOCYTES | O-2 HOMEOSTASIS | CARDIAC MYOCYTE | MARROW STEM-CELLS | PHARMACOLOGY & PHARMACY | ISCHEMIA-REPERFUSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 07/2018, Volume 125, Issue 1, pp. 124 - 133
Journal Article