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ACS Chemical Biology, ISSN 1554-8929, 09/2018, Volume 13, Issue 9, pp. 2534 - 2541
O-6-Alkylguanine DNA adducts are repaired by the suicide enzyme alkylguanine alkyltransferase (AGT). AGT facilitates repair by binding DNA in the minor groove,... 
DAMAGED DNA | CONFORMATIONAL DIFFERENCES | ALKYLATED DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLESION SYNTHESIS | SYNTHETIC NUCLEOSIDE | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | CYTOSINE METHYLATION | O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE | ARTIFICIAL NUCLEOTIDE OPPOSITE | SEQUENCE CONTEXT
Journal Article
DNA Repair, ISSN 1568-7864, 2007, Volume 6, Issue 8, pp. 1222 - 1228
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 81, Issue 10, pp. 1201 - 1210
To most effectively treat cancer it may be necessary to preferentially destroy tumor tissue while sparing normal tissues. One strategy to accomplish this is to... 
O 6-alkylguanine-DNA alkyltransferase | Oxygen-deficient cells | 1,2-Bis(sulfonyl)hydrazines | KS900 | Onrigin | alkylguanine-DNA alkyltransferase | LYSYL OXIDASE | METHYLTRANSFERASE | CANCER | VNP40101M | TEMOZOLOMIDE | OXYGEN | LAROMUSTINE | PHARMACOLOGY & PHARMACY | O-6-alkylguanine-DNA alkyltransferase | INHIBITORS | Onrigin (TM) | PHASE-I | CYTOTOXICITY
Journal Article
by Sun, GH and Zhao, LJ and Fan, TJ and Ren, T and Zhong, RG
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, ISSN 1570-0232, 10/2016, Volume 1033, pp. 138 - 146
The repair of DNA mediated by O-6-alkylguanine-DNA alkyltransferase (AGT) provides protection against DNA damage from endogenous or exogenous alkylation of the... 
CHEMISTRY, ANALYTICAL | ASSAY | PROMOTER METHYLATION | BIOCHEMICAL RESEARCH METHODS | DNA-REPAIR PROTEIN | PHASE-II | O-6-benzylguanine | CANCER | INACTIVATION | HPLC-ESI-MS/MS | AGT activity | O-6-alkylguanine-DNA alkyltransferase | INTERSTRAND CROSS-LINKS | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | MGMT ACTIVITY | Tumour cells
Journal Article
DNA Repair, ISSN 1568-7864, 2007, Volume 6, Issue 8, pp. 1071 - 1078
Journal Article
PROTEIN ENGINEERING DESIGN & SELECTION, ISSN 1741-0126, 07/2006, Volume 19, Issue 7, pp. 309 - 316
The specific reaction of O-6-alkylguanine-DNA alkyltransferase (AGT) with O-6-benzylguanine (BG) derivatives allows for a specific labeling of AGT fusion... 
SYSTEM | VITRO | MUTAGENESIS | protein labeling | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | O-6-alkylguanine-DNA alkyltransferases | REPAIR | phage display | CHEMICAL COMPLEMENTATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOLECULES IN-VIVO | DNA ALKYLTRANSFERASES | directed evolution | FUSION PROTEINS
Journal Article
CHEMISTRY-AN ASIAN JOURNAL, ISSN 1861-4728, 02/2016, Volume 11, Issue 4, pp. 576 - 583
Oligonucleotides containing an alkylene intrastrand cross-link (IaCL) between the O-6-atoms of two consecutive 2-deoxyguanosines (dG) were prepared by... 
PROTEIN | RECOGNITION | MECHANISM | DNA damage | MITOMYCIN-C | INTERSTRAND | SPORE PHOTOPRODUCT | ADDUCTS | oligonucleotides | DNA repair | O-6-alkylguanine DNA alkyltransferase | CHEMISTRY, MULTIDISCIPLINARY | DAMAGE | CELLULAR-RESPONSES | intrastrand cross-link | IN-VIVO
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 12/2009, Volume 113, Issue 51, pp. 16285 - 16290
Journal Article
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 06/2009, Volume 389, Issue 2, pp. 248 - 263
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2012, Volume 109, Issue 46, pp. 18755 - 18760
Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA... 
ESCHERICHIA-COLI ADA | DAMAGE RECOGNITION | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | CATALYTIC EFFICIENCY | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | GENE-PRODUCT | NUCLEOTIDE EXCISION-REPAIR | BASE
Journal Article