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DNA Repair, ISSN 1568-7864, 2007, Volume 6, Issue 8, pp. 1079 - 1099
O -methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O -alkylguanine... 
Alkyltransferase | MGMT | Carmustine | Alkylating agents | Genotoxicity | Temozolomide | Carcinogenicity | Drug resistance | Tumor therapy | temozolomide | METHYL-N-NITROSOUREA | BASE-EXCISION-REPAIR | alkylating agents | DNA-POLYMERASE-BETA | carcinogenicity | tumor therapy | PROTEIN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | REVERSES TEMOZOLOMIDE RESISTANCE | genotoxicity | carmustine | CHINESE-HAMSTER CELLS | GENETICS & HEREDITY | alkyltransferase | HUMAN-MELANOMA CELLS | TOXICOLOGY | drug resistance | INTERSTRAND CROSS-LINKS | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY | SISTER-CHROMATID EXCHANGES | Neoplasms - metabolism | Neoplasms - etiology | Apoptosis - drug effects | Humans | DNA Repair Enzymes - genetics | Alkylation | Necrosis | Alkylating Agents - toxicity | Neoplasms - genetics | DNA Mismatch Repair | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Sister Chromatid Exchange | Gene Expression | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | O-Methylguanine-DNA Methyltransferase - metabolism | DNA - metabolism | O-Methylguanine-DNA Methyltransferase - genetics | DNA - chemistry | DNA Modification Methylases - genetics | Animals | Models, Biological | DNA Repair | Chromosome Aberrations | DNA Damage | Mutation | In Vitro Techniques | Physiological aspects | DNA synthesis | DNA replication | Apoptosis
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2013, Volume 23, Issue 6, pp. 1853 - 1859
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2005, Volume 433, Issue 2, pp. 369 - 378
Mechanisms of toxicity continue to be important in developing rational strategies to deal with chemicals present in the environment. Understanding and... 
Toxicity | bis-Electrophiles | Vinyl halides | O6-Alkylguanine DNA alkyltransferase | Covalent binding | Aflatoxin | Glutathione | Alkylguanine DNA alkyltransferase | toxicity | DNA-ADDUCTS | HUMAN O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | INDUCED HEPATIC NECROSIS | bis-electrophiles | glutathione | ETHYLENE DIBROMIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | O-6-alkylguanine DNA Alkyltransferase | aflatoxin | TRICHLOROETHYLENE OXIDE | BIOPHYSICS | colalent binding | vinyl halides | SALMONELLA-TYPHIMURIUM | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | GLUTATHIONE-S-TRANSFERASE | AFLATOXIN B-1 EXO-8,9-EPOXIDE | DNA Adducts - toxicity | Models, Chemical | Escherichia coli - drug effects | Humans | Half-Life | Aflatoxin B1 - metabolism | Lysine - metabolism | Salmonella typhimurium - drug effects | Aflatoxin B1 - chemistry | Tetrachloroethylene - toxicity | Butadienes - toxicity | Trichloroethylene - toxicity | Oxidation-Reduction | Salmonella typhimurium - genetics | Signal Transduction | Tetrachloroethylene - metabolism | O-Methylguanine-DNA Methyltransferase - metabolism | Trichloroethylene - metabolism | Ethylene Dibromide - metabolism | Forecasting | Aflatoxin B1 - toxicity | Escherichia coli - genetics | DNA Damage | Enzyme Activation | Kinetics | Mutation | Trichloroethylene - chemistry | Mutagens - metabolism | Mutagens - toxicity | Glutathione - metabolism | DNA Adducts - metabolism | Dose-Response Relationship, Drug | Biotransformation | Mutagenicity Tests | Molecular Structure | Tetrachloroethylene - chemistry | Genes, Bacterial | Mutagens - chemistry | Cross-Linking Reagents - chemistry | Trichloroethylene - pharmacology | DNA Adducts - chemistry | Hydrolysis | Animals | Ethylene Dibromide - chemistry | Butadienes - metabolism | DNA | DNA Repair | Butadienes - chemistry | Ethylene Dibromide - toxicity
Journal Article
Journal Article
MINI-REVIEWS IN MEDICINAL CHEMISTRY, ISSN 1389-5575, 2016, Volume 16, Issue 6, pp. 455 - 464
O-6-Methylguanine-DNA-methyltransferase (MGMT) is an antimutagenic DNA repair protein highly expressed in human brain tumors. Because MGMT repairs the... 
OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | REPAIR PROTEIN | Alkylating agents | DNA-DAMAGE | Drug repurposing | TUMOR-CELLS | DNA repair | Reactive cysteines | SENSITIVE PROTEINS | IN-VITRO | Protein glutathionylation | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | gliomas | MULTIDRUG-RESISTANCE | NF-KAPPA-B
Journal Article
Chemical science, ISSN 2041-6520, 01/2016, Volume 7, Issue 1, pp. 301 - 307
In this paper, we introduce a general design to construct fluorescence-switching probes by using conjugates of a fluorescent molecular rotor and protein... 
Journal Article
Journal Article