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Book Chapter
Neuropathology and Applied Neurobiology, ISSN 0305-1846, 02/2018, Volume 44, Issue 2, pp. 172 - 184
Journal Article
Brain Pathology, ISSN 1015-6305, 10/2008, Volume 18, Issue 4, pp. 520 - 532
Silencing of O6-methylguanine-DNA methyltransferase (MGMT) protein expression because of MGMT gene promoter hypermethylation is considered to be associated... 
glioblastoma | immunohistochemistry | biomarker | MGMT | prognosis | Immunohistochemistry | Biomarker | Prognosis | Glioblastoma | METHYLATION ANALYSIS | PROMOTER HYPERMETHYLATION | MISMATCH REPAIR | PATHOLOGY | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE GENE | NEUROSCIENCES | CLINICAL NEUROLOGY | BRAIN-TUMORS | DNA-DAMAGING AGENTS | INTERLABORATORY VALIDATION | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | MALIGNANT GLIOMAS | INTEROBSERVER REPRODUCIBILITY | Antibody Specificity | Predictive Value of Tests | Glioblastoma - enzymology | Prospective Studies | Humans | Middle Aged | Brain Neoplasms - physiopathology | DNA Repair Enzymes - genetics | Antibodies | Promoter Regions, Genetic - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Biomarkers, Tumor - metabolism | Adult | DNA Modification Methylases - analysis | Brain Neoplasms - enzymology | Diagnosis, Differential | Reproducibility of Results | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Glioblastoma - diagnosis | Biomarkers, Tumor - analysis | Brain Neoplasms - diagnosis | Survival Rate | DNA Repair Enzymes - analysis | Immunohistochemistry - methods | DNA Modification Methylases - genetics | Aged | Glioblastoma - physiopathology | Observer Variation | Cohort Studies | Tumor Suppressor Proteins - analysis | Algorithms | Methylation | Glioblastoma multiforme | Patient outcomes
Journal Article
Science, ISSN 0036-8075, 9/1997, Volume 277, Issue 5334, pp. 1996 - 2000
DNA-(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are unknown. Here, MCMT is shown... 
DNA | Cell nucleus | DNA damage | Genomics | Cell cycle | Antibodies | Reports | Methylation | Codons | DNA repair | Cell extracts | CYCLIN-DEPENDENT KINASES | BINDING DOMAINS | METHYLATION | REPLICATION | CELL NUCLEAR ANTIGEN | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | HISTONE H1 | K RO MULTIDISCIPLINARY SCIENCES | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | POLYMERASE-III | NUCLEOTIDE EXCISION-REPAIR | Research
Journal Article
British Medical Bulletin, ISSN 0007-1420, 3/2008, Volume 85, Issue 1, pp. 17 - 33
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74466
Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of... 
OVEREXPRESSION | GLIOBLASTOMA | PROMOTER METHYLATION | MULTIDISCIPLINARY SCIENCES | MALIGNANT GLIOMAS | MICE | MICRORNAS | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | CANCER | TUMORIGENESIS | ADJUVANT TEMOZOLOMIDE | DNA Damage - drug effects | Humans | RNA, Messenger - genetics | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | Antineoplastic Agents, Alkylating - pharmacology | Apoptosis - genetics | Glioma - metabolism | Glioma - genetics | DNA Modification Methylases - genetics | Drug Resistance, Neoplasm - genetics | RNA Interference | Dacarbazine - pharmacology | Tumor Suppressor Proteins - genetics | Dacarbazine - analogs & derivatives | Cell Line, Tumor | DNA Damage - genetics | MicroRNAs - genetics | Temozolomide | MicroRNA | Gliomas | Cell death | DNA damage | Transferases | DNA | Genetic aspects | Methylation | Cancer | Biotechnology | Brain tumors | Glioblastoma | mRNA | Kinases | Chromosome rearrangements | Cancer therapies | DNA repair | Alkylation | O6-methylguanine-DNA methyltransferase | Proteins | Rodents | Glioma cells | Penicillin | DNA methylation | Tumorigenesis | Damage | Deoxyribonucleic acid--DNA | Enzymes | Methylguanine | MiRNA | Cell division | Radiation therapy | Forensic medicine | Gene expression | Ribonucleic acid--RNA | Patients | Glioblastoma multiforme | Pathology | MicroRNAs | Medical prognosis | Regulatory mechanisms (biology) | Epigenetics | DNA methyltransferase | Chromosome aberrations | Tumors | Apoptosis | Càncer | Glioma | ADN | Micro RNAs | RNA | Deoxyribonucleic acid | miRNA | Ribonucleic acid
Journal Article
by Yang, L and Li, WH and Zhao, YJ and Zhong, S and Wang, XH and Jiang, SS and Cheng, Y and Xu, HY and Zhao, G
WORLD NEUROSURGERY, ISSN 1878-8750, 10/2019, Volume 130, pp. E294 - E306
OBJECTIVE: To screen ideal lead compounds from a drug library (ZINC15 database) with potential inhibition effect against O-6-methylguanine-DNA... 
SURGERY | METHYLATION | MGMT | O-6-methylguanine-DNA methyltransferase (MGMT) | Virtual screening | SENSITIVITY | O-6-Benzylguanine (O-6-BG) | PROGNOSTIC VALUE | O-6-BENZYLGUANINE | CHEMOTHERAPY | CLINICAL NEUROLOGY | INACTIVATION | HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | DNA | RESISTANCE | Discovery Studio | Inhibitor
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, ISSN 0304-419X, 12/2011, Volume 1816, Issue 2, pp. 179 - 190
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 12/2003, Volume 22, Issue 55, pp. 8835 - 8844
Journal Article
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 02/2006, Volume 96, Issue 3, pp. 766 - 776
Temozolomide (TMZ) is a methylating agent which prolongs survival when administered during and after radiotherapy in the first-line treatment of glioblastoma... 
temozolomide | WILD-TYPE P53 | DAMAGING AGENTS | BCL-XL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | p53 | PHASE-II TRIAL | glioblastoma | O-6-methylguanine DNA methyltransferase | ALKYLATING-AGENTS | O6-METHYLGUANINE-DNA METHYLTRANSFERASE | 1ST RELAPSE | MISMATCH REPAIR-DEFICIENT | MUTANT P53 | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | HUMAN TUMOR-CELLS
Journal Article