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o-alkylguanine-dna alkyltransferase (39) 39
human o-alkylguanine-dna alkyltransferase (35) 35
dna repair (28) 28
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agt (4) 4
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alkylguanine dna alkyltransferase (3) 3
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CHEMBIOCHEM, ISSN 1439-4227, 03/2018, Volume 19, Issue 6, pp. 575 - 582
Journal Article
DNA Repair, ISSN 1568-7864, 2007, Volume 6, Issue 8, pp. 1071 - 1078
Journal Article
Journal Article
BIOESSAYS, ISSN 0265-9247, 03/2002, Volume 24, Issue 3, pp. 255 - 266
The DNA in human cells is continuously undergoing damage as consequences of both endogenous processes and exposure to exogenous agents. The resulting... 
RAT-LIVER DNA | METHYLATING AGENTS | GENE O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | ALKYLATING-AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | NITRO-N-NITROSOGUANIDINE | DNA-REPAIR GENES | HUMAN O-METHYLGUANINE-DNA METHYLTRANSFERASE | MISMATCH REPAIR | TUMOR-CELLS | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 04/2008, Volume 21, Issue 4, pp. 787 - 795
The antitumor activity of chemotherapeutic nitrogen mustards including chlorambucil, cyclophosphamide, and melphalan is commonly attributed to their ability to... 
CELLS | CHEMISTRY, MEDICINAL | AGENT-INDUCED TOXICITY | CYCLOPHOSPHAMIDE-INDUCED TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | MUTAGENICITY | INACTIVATION | ALKYLATING-AGENTS | RESISTANCE | TOXICOLOGY | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | BINDING
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 8185 - 8195
O-6-Alkylguanine-DNA alkyltransferase (AGT) plays a major role in repair of the cytotoxic and mutagenic lesion O-6-methylguanine (m(6)G) in DNA. Unlike the... 
ESCHERICHIA-COLI ADA | DAMAGE RECOGNITION | DIFFERENTIAL INACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | DNA-BINDING MECHANISM | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | GENE-PRODUCT | NUCLEOTIDE EXCISION-REPAIR
Journal Article
Biochemistry, ISSN 0006-2960, 10/2008, Volume 47, Issue 41, pp. 10892 - 10903
O 6-Alkylguanine-DNA alkyltransferase (AGT) plays an important role by protecting cells from alkylating agents. This reduces the frequency of carcinogenesis... 
DNA-BINDING | HUMAN O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | HUMAN-TUMOR CELLS | CANCER-CHEMOTHERAPY | ALKYLATING-AGENTS | DIFFERENTIAL INACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMATOPOIETIC STEM-CELLS | ESCHERICHIA-COLI | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE
Journal Article
DNA REPAIR, ISSN 1568-7864, 08/2014, Volume 20, pp. 14 - 22
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2005, Volume 280, Issue 35, pp. 30873 - 30881
Journal Article
Chemistry & Biology, ISSN 1074-5521, 2003, Volume 10, Issue 4, pp. 313 - 317
We report here the generation of mutants of the human O-6-alkylguanine-DNA alkyltransferase (hAGT) for the efficient in vivo labeling of fusion proteins with... 
VITRO | MOTIFS | REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | SELECTION | EXPRESSION | PHAGE | LIVING CELLS | PROBES
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 12/2007, Volume 20, Issue 12, pp. 1966 - 1971
O 6-Alkylguanine-DNA alkyltransferase (AGT) repairs O 6-alkylguanine residues at different rates depending on the identity of the alkyl group as well as the... 
OLIGODEOXYNUCLEOTIDES | CHEMISTRY, MEDICINAL | HUMAN O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | PROTEIN | OXIDATIVE DEMETHYLATION | O-6-METHYLGUANINE | ANALOGS | ESCHERICHIA-COLI | DNA ALKYLTRANSFERASE | CHEMISTRY, MULTIDISCIPLINARY | BASE | TOXICOLOGY | BINDING
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2008, Volume 51, Issue 22, pp. 7144 - 7153
O 6-Benzylguanine is an irreversible inactivator of O 6-alkylguanine-DNA alkyltransferase currently in clinical trials to overcome alkyltransferase-mediated... 
PHASE-II TRIAL | DNA-BINDING | IN-VITRO | CHEMISTRY, MEDICINAL | SOLID TUMORS | ACCURATE DOCKING | ALKYLATING-AGENTS | MALIGNANT BRAIN-TUMORS | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | MOLECULAR DOCKING | TEMOZOLOMIDE
Journal Article
Biochemistry, ISSN 0006-2960, 09/2003, Volume 42, Issue 37, pp. 10965 - 10970
The active site cysteine of human O 6-alkylguanine-DNA alkyltransferase (hAGT), Cys145, was shown to be highly reactive with model electrophiles unrelated to... 
ESCHERICHIA-COLI ADA | REPAIR PROTEIN | ACTIVE-SITE | ALKYLATING-AGENTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | NITRIC-OXIDE | O-ALKYLGUANINE-DNA ALKYLTRANSFERASE | DNA ALKYLTRANSFERASE | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE
Journal Article
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