X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
o-desmethyltramadol (163) 163
tramadol (131) 131
index medicus (85) 85
humans (71) 71
pharmacokinetics (66) 66
pharmacology & pharmacy (59) 59
metabolites (54) 54
animals (53) 53
chemistry, analytical (51) 51
male (51) 51
tramadol - pharmacokinetics (48) 48
analgesics, opioid - pharmacokinetics (44) 44
tramadol - blood (43) 43
human plasma (40) 40
tramadol - analogs & derivatives (36) 36
veterinary sciences (35) 35
pain (33) 33
female (32) 32
tramadol - administration & dosage (32) 32
analgesics, opioid - administration & dosage (31) 31
analgesics, opioid - blood (31) 31
analysis (30) 30
biochemical research methods (28) 28
urine (28) 28
enantiomers (27) 27
morphine (27) 27
performance liquid-chromatography (25) 25
cyp2d6 (22) 22
mass-spectrometry (22) 22
analgesia (21) 21
hplc method (21) 21
reproducibility of results (21) 21
tramadol - metabolism (21) 21
tramadol - pharmacology (21) 21
desmetramadol (20) 20
solid-phase extraction (20) 20
tramadol - urine (20) 20
capillary gas-chromatography (19) 19
patient-controlled analgesia (19) 19
validation (19) 19
hydrochloride (18) 18
pharmacology (18) 18
administration, oral (17) 17
adult (17) 17
analgesics (17) 17
analgesics, opioid - metabolism (17) 17
area under curve (17) 17
main metabolites (16) 16
rats (16) 16
liquid-chromatography (15) 15
mass spectrometry (15) 15
metabolism (15) 15
active metabolite (14) 14
analgesics, opioid - pharmacology (14) 14
analgesics, opioid - therapeutic use (14) 14
analgesics, opioid - urine (14) 14
chromatography (14) 14
dogs (14) 14
horses (14) 14
stereoisomerism (14) 14
tramadol - therapeutic use (14) 14
cross-over studies (13) 13
extraction (13) 13
half-life (13) 13
plasma (13) 13
tramadol - chemistry (13) 13
chromatography, high pressure liquid - methods (12) 12
liquid chromatography (12) 12
metabolite (12) 12
n-desmethyltramadol (12) 12
postoperative pain (12) 12
cytochrome p-450 cyp2d6 - genetics (11) 11
drugs (11) 11
human urine (11) 11
kratom (11) 11
neurosciences (11) 11
rat (11) 11
bioavailability (10) 10
human liver-microsomes (10) 10
methods (10) 10
middle aged (10) 10
molecularly imprinted polymer (10) 10
opioids (10) 10
phase-i metabolites (10) 10
release (10) 10
sensitivity and specificity (10) 10
toxicology (10) 10
analgesics, opioid - chemistry (9) 9
chemistry (9) 9
double-blind (9) 9
efficacy (9) 9
identification (9) 9
limit of detection (9) 9
metabolite o-desmethyltramadol (9) 9
methods and techniques (9) 9
mitragynine (9) 9
molecular structure (9) 9
pharmacology/toxicology (9) 9
pharmacy (9) 9
rats, wistar (9) 9
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Jeong and Bae and Lee and Kim and Jang and Shin
Pharmaceutics, ISSN 1999-4923, 11/2019, Volume 11, Issue 11, p. 618
Tramadol is a μ-opioid receptor agonist and a monoamine reuptake inhibitor. O-desmethyltramadol (M1), the major active metabolite of tramadol, is produced by... 
pharmacokinetics | tramadol | o-desmethyltramadol | physiologically-based pharmacokinetics | cyp2d6
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 03/2016, Volume 157, pp. 258 - 264
The UV spectrophotometric methods for simultaneous quantitative determination of paracetamol and tramadol in paracetamol-tramadol tablets were developed. The... 
Chemometric methods | Paracetamol | Tablets | UV spectrometry | Tramadol | Quantitative determination | HUMAN PLASMA | ARTIFICIAL NEURAL-NETWORK | QUALITY-CONTROL | O-DESMETHYLTRAMADOL | ASCORBIC-ACID | MULTIVARIATE CALIBRATION | CAPILLARY GAS-CHROMATOGRAPHY | WAVELENGTH SELECTION | SPECTROSCOPY | PARTIAL LEAST-SQUARES | TERNARY MIXTURE | Algorithms | Acetaminophen | Analysis | Methods | Chromatography
Journal Article
Analyst (Cambridge UK), ISSN 0003-2654, 08/2015, Volume 140, Issue 17, pp. 5965 - 5970
There is an on going requirement for the detection and quantification of illicit substances. This is in particular the case for law enforcement where portable... 
Urine | Equivalence | Raman scattering | Mathematical analysis | Colloids | Agglomeration | Spiking
Journal Article
Journal Article
Journal of Veterinary Pharmacology and Therapeutics, ISSN 0140-7783, 07/2019, Volume 42, Issue 4, pp. 380 - 384
This study documents the pharmacokinetics of oral tramadol in Muscovy ducks. Six ducks received a single 30 mg/kg dose of tramadol, orally by stomach tube,... 
tramadol | O‐desmethyl‐tramadol | duck | analgesia | O-desmethyl-tramadol | RAT | ENANTIOMERS | METABOLITE O-DESMETHYLTRAMADOL | RELEASE | HYDROCHLORIDE | PAIN | PHARMACOLOGY & PHARMACY | VETERINARY SCIENCES | ANALGESIC EFFICACY | Ducks
Journal Article
Psychopharmacology, ISSN 0033-3158, 2/2018, Volume 235, Issue 2, pp. 573 - 589
Consideration by the US Drug Enforcement Administration and Food and Drug Administration of placing kratom into Schedule I of the Controlled Substances Act... 
Neurosciences | Withdrawal | Mitragynine | Controlled Substances Act | Opioid | Biomedicine | Analgesic | Kratom | Dependence | Dietary ingredient | Pharmacology/Toxicology | Abuse potential | Psychiatry | Food and Drug Administration | DRUG | PSYCHIATRY | SALVIA-DIVINORUM | CAFFEINE | O-DESMETHYLTRAMADOL | NEUROSCIENCES | MITRAGYNA-SPECIOSA KORTH | PHARMACOLOGY | URINE | PHARMACOLOGY & PHARMACY | MICE | CONSUMPTION | FOOD | Mitragyna - chemistry | Secologanin Tryptamine Alkaloids - adverse effects | United States | Humans | Substance Withdrawal Syndrome - drug therapy | Analgesics, Opioid - therapeutic use | Biomedical Research - trends | Secologanin Tryptamine Alkaloids - administration & dosage | Controlled Substances - adverse effects | United States Food and Drug Administration - legislation & jurisprudence | Biomedical Research - legislation & jurisprudence | Pain - psychology | Substance-Related Disorders - prevention & control | Pain - drug therapy | Substance-Related Disorders - psychology | Quality of Life - psychology | Controlled Substances - administration & dosage | Substance Withdrawal Syndrome - psychology | Medication abuse | Analysis | Drug abuse | Evaluation | Regulatory agencies | Narcotics | Molecular structure | Health problems | Health risks | Pharmacology | Mental depression | Quality of life | Control | Pain | Mood | Psychopharmacology | Opioids | Public health | Review
Journal Article
Analyst, ISSN 0003-2654, 09/2015, Volume 140, Issue 17, pp. 5965 - 5970
There is an on going requirement for the detection and quantification of illicit substances. This is in particular the case for law enforcement where portable... 
CHEMISTRY, ANALYTICAL | METABOLITES | ABUSE | O-DESMETHYLTRAMADOL | ENANTIOMERIC DETERMINATION | HYDROCHLORIDE | DEPENDENCE | Colloids - chemistry | Humans | Silver - chemistry | Spectrum Analysis, Raman | Tramadol - urine | Hydroxylamine - chemistry | Analgesics, Opioid - urine | Hydrogen-Ion Concentration | Sodium Chloride - chemistry
Journal Article
Drug design, development and therapy, ISSN 1177-8881, 2019, Volume 13, pp. 1751 - 1761
Tramadol is widely used to treat acute, chronic, and neuropathic pain. Its primary active metabolite, desmethyltramadol (M1), is mainly responsible for its... 
tramadol | pharmacokinetics | population model | CYP2D610 | O-desmethyltramadol
Journal Article
Molecular Pain, ISSN 1744-8069, 01/2019, Volume 15, p. 1744806918824243
To reveal cellular mechanisms for antinociception produced by clinically used tramadol, we investigated the effect of its metabolite O-desmethyltramadol (M1)... 
O-Desmethyltramadol | antinociception | patch-clamp | μ-opioid receptor | glutamatergic synaptic transmission | spinal substantia gelatinosa | CORD | TRAMADOL | MECHANISM | SYNAPTIC-TRANSMISSION | NEUROSCIENCES | DORSAL-HORN | A-DELTA | mu-opioid receptor | OPIOID RECEPTORS | NORADRENALINE | METABOLITE | MODULATION
Journal Article