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CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 52, pp. 7446 - 7449
A facile and practical approach for the difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt was developed. A wide variety of... 
FLUORINE | ETHERS | O-DIFLUOROMETHYLATION | ACID | DIFLUOROCARBENE REAGENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Synthesis, ISSN 0039-7881, 04/2014, Volume 46, Issue 7, pp. 842 - 863
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 11, pp. 3217 - 3222
Intermolecular C-H difluoromethoxylation of (hetero) arenes remains a long-standing and unsolved problem in organic synthesis. Herein, we report the first... 
FUNCTIONALIZATION | TRANSITION-METAL-COMPLEXES | DIFLUOROCARBENE | PHARMACEUTICALS | PHENOLS | FLUORINE | O-DIFLUOROMETHYLATION | GENERATION | CHEMISTRY, MULTIDISCIPLINARY | PHOTOREDOX CATALYSIS | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 11/2018, Volume 20, Issue 21, pp. 6925 - 6929
Air- and light-stable electrophilic difluoromethylating reagents, S-(difluoromethyl)-S-phenyl-S-(2,4,6-trialkoxyphenyl) sulfonium salts were successfully... 
MEDICINAL CHEMISTRY | TRIFLUOROMETHYLATING AGENTS | CARBON NUCLEOPHILES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | O-DIFLUOROMETHYLATION | GEM-DIFLUOROCYCLOPROPANES | BROMODIFLUOROMETHYLATING REAGENTS | DIFLUOROCARBENE SOURCE | SULFONIUM YLIDE | CARBOXYLIC-ACIDS
Journal Article
by Tang, L and Yang, Z and Jiao, JC and Cui, Y and Zou, GD and Zhou, QJ and Zhou, YQ and Rao, WH and Ma, XT
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 08/2019, Volume 84, Issue 16, pp. 10449 - 10458
By altering the amount of Selectfluor, the highly selective mono- and difluorination of 1,3-dicarbonyl compounds has been achieved, affording a variety of... 
CATALYZED FLUORINATION | MEDIATED FLUORINATION | C-H FLUORINATION | STRATEGY | CHEMISTRY, ORGANIC | O-DIFLUOROMETHYLATION | STEREOSELECTIVE-SYNTHESIS | SALTS | ELECTROPHILIC TRIFLUOROMETHYLATING AGENTS | 1,3-DIONES | RADICAL FLUORINATION
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 02/2016, Volume 14, Issue 5, pp. 1531 - 1535
Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report... 
ENHANCED THERMAL-STABILITY | ELECTROPHILIC FLUORINATION | CHEMISTRY, ORGANIC | SPECTRUM DEOXOFLUORINATING AGENT | FLUORINATED GEM-DIOLS | CARBONYL-COMPOUNDS | TERMINAL ALKYNES | ALDOL REACTIONS | O-DIFLUOROMETHYLATION | BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE | IN-SITU
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2019, Volume 75, Issue 35, p. 130472
A convenient synthesis of 2-(2-(difluoromethoxy)aryl)benzo[d]thiazoles from 2- (o-hydroxyaryl)benzothiazoles and commercially available ethyl... 
2-arylbenzo[d]thiazoles | O-hydroxybenzaldehyde | O-aminothiophenol | O-difluoromethylation | Ethyl difluoroiodoacetate | CHEMISTRY, ORGANIC | ALCOHOLS | KETONES | ETHERS | 2-ARYLBENZOTHIAZOLES | FLUORINE | 2-arylbenzoiclithiazoles | ARYL | DIFLUOROCARBENE REAGENT | 1,3-DIONES
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 33, pp. 9758 - 9762
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2019, Volume 58, Issue 33, pp. 11171 - 11181
Trifluoromethoxy (OCF3) and difluoromethoxy (OCF2H) groups are fluorinated structural motifs that exhibit unique physicochemical characteristics. Incorporation... 
drug discovery | radicals | photochemistry | synthetic methods | fluorine | DIFLUOROCARBENE | PHARMACEUTICALS | ARENES | TRIFLUOROMETHOXYLATION | CHEMISTRY, MULTIDISCIPLINARY | (HETERO)ARENES | ALPHA-FLUORINATED ETHERS | O-DIFLUOROMETHYLATION | GENERATION | THIOETHERS | ACCESS | Chemical synthesis | Drug discovery | Catalysis | Organic chemistry | Open reading frames | Ethers | Fluorination | Functional groups
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 06/2017, Volume 198, pp. 34 - 46
Depending on the substitution pattern, fluorinated propyloxy groups can alter their lipophilicity by conformational changes and thus adapt to chemical... 
Metabolic stability | Conformations | Bond vector model | 5-Alkoxyindoles | Fluorinated alkoxy groups | Lipophilicity | X-ray structures | POLARITY | ALKYL | DRUG DISCOVERY | FLUOROALKYLATION | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR | MEDICINAL CHEMISTRY | ALCOHOLS | O-DIFLUOROMETHYLATION | Drug discovery | Structure | Bonds | Analysis | Crystals
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 08/2019, Volume 30, Issue 8, pp. 1515 - 1518
A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones with S-(difluoromethyl)sulfonium salt was developed, and a wide... 
S-(Difluoromethy)sulfonium salt | 1,3-Diones | Difluoromethyl enol ethers | O-Difluoromethylation | Difluorocarbene | ALCOHOLS | ETHERS | FLUORINE | DIFLUOROCARBENE REAGENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 09/2019, Volume 361, Issue 18, pp. 4360 - 4368
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 12/2016, Volume 192, pp. 27 - 30
•Under mild conditions, O-difluoromethylation of 1,3-diones with difluorocarbene occurred smoothly.•No base or additive was required for this... 
1,3-diones | O-difluoromethylation | Base-free | Difluorocarbene | PRECURSOR | REAGENTS | ACID | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR | ALCOHOLS | NUCLEOPHILES | ETHERS | PHOSPHABETAINE | AMINES | CHEMISTRY | YLIDE
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2018, Volume 2018, Issue 27-28, pp. 3724 - 3734
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 11/2018, Volume 36, Issue 11, pp. 1069 - 1074
Journal Article