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oatp1b1 (252) 252
index medicus (232) 232
humans (209) 209
pharmacology & pharmacy (197) 197
pharmacokinetics (140) 140
solute carrier organic anion transporter family member 1b1 (104) 104
male (96) 96
organic anion transporters - genetics (94) 94
organic anion transporters - metabolism (86) 86
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animals (67) 67
adult (55) 55
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slco1b1 (49) 49
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genotype (45) 45
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hek293 cells (43) 43
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middle aged (39) 39
metabolism (38) 38
pharmacology (38) 38
solute carrier organic anion transporter family member 1b3 (37) 37
transporter (36) 36
genetic polymorphisms (35) 35
oatp1b3 (35) 35
polymorphism, single nucleotide (34) 34
biological transport (33) 33
organic anion transporters - antagonists & inhibitors (33) 33
cell line (32) 32
organic anion transporters, sodium-independent - metabolism (32) 32
rosuvastatin (32) 32
kinetics (31) 31
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pitavastatin (29) 29
polymorphism (29) 29
toxicology (29) 29
analysis (28) 28
area under curve (28) 28
in-vitro (28) 28
pharmacology/toxicology (28) 28
transporters (28) 28
inhibition (27) 27
organic anion transporting polypeptide (27) 27
p-glycoprotein (27) 27
atorvastatin (26) 26
chemistry, multidisciplinary (26) 26
human liver (26) 26
research (25) 25
article (24) 24
drugs (24) 24
healthy-volunteers (24) 24
hydroxymethylglutaryl-coa reductase inhibitors - pharmacokinetics (24) 24
polypeptides (24) 24
variants (24) 24
biomedicine (23) 23
oatp-c slc21a6 (23) 23
young adult (23) 23
genetic aspects (22) 22
oncology (22) 22
organic anion transporters, sodium-independent - genetics (22) 22
polymorphism, genetic (22) 22
polymorphisms (22) 22
slco1b1 polymorphism (22) 22
anion transporting polypeptide (20) 20
metabolites (20) 20
aged (19) 19
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hepatocytes - drug effects (19) 19
mice (19) 19
plasma-concentrations (19) 19
biochemistry & molecular biology (18) 18
dose-response relationship, drug (18) 18
drug interaction (18) 18
gemfibrozil (18) 18
hepatocytes (18) 18
pharmacy (18) 18
administration, oral (17) 17
cyclosporine-a (17) 17
models, biological (17) 17
oatp (17) 17
transport (17) 17
health aspects (16) 16
human oatp1b1 (16) 16
oatp1b1 oatp-c (16) 16
pharmaceutical preparations - metabolism (16) 16
simvastatin (16) 16
genetics & heredity (15) 15
liver - drug effects (15) 15
medicine, research & experimental (15) 15
mice, knockout (15) 15
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CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 05/2006, Volume 79, Issue 5, pp. 427 - 439
Objective: Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of... 
CONVERTING ENZYME-INHIBITOR | COA REDUCTASE INHIBITOR | SLCO1B1 | ANGIOTENSIN-II ANTAGONIST | OATP1B1 OATP-C | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | HEPATIC-UPTAKE | ENCODING OATP1B1 | SINGLE NUCLEOTIDE POLYMORPHISMS | DRUG-DRUG INTERACTION
Journal Article
Journal of clinical pharmacy and therapeutics, ISSN 0269-4727, 10/2017, Volume 42, Issue 5, pp. 547 - 553
Journal Article
European Journal of Drug Metabolism and Pharmacokinetics, ISSN 0378-7966, 09/2014, Volume 39, Issue 3, pp. 221 - 230
Journal Article
Xenobiotica, ISSN 0049-8254, 10/2018, Volume 48, Issue 10, pp. 1059 - 1071
1. Organic anion-transporting polypeptide 1B1 (OATP1B1) plays an important role in the hepatic uptake of a broad range of substrate drugs. In vitro experiments... 
inhibition | Drug interaction | tyrosine kinase inhibitor | OATP1B1 | transporter | stimulation | OATP1B1 OATP-C | UREMIC TOXINS | HEPATIC-UPTAKE | DOSAGE FORM | ATORVASTATIN | TYROSINE KINASE INHIBITORS | IN-VITRO | CYCLOSPORINE-A | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DRUG-DRUG INTERACTIONS | Index Medicus
Journal Article
Oncology Reports, ISSN 1021-335X, 5/2015, Volume 33, Issue 5, pp. 2420 - 2428
Journal Article
PHARMACOGENOMICS, ISSN 1462-2416, 01/2008, Volume 9, Issue 1, pp. 19 - 33
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 10/2013, Volume 41, Issue 10, pp. 1859 - 1866
Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic uptake of many drugs, and the evaluation of OATP1B1-mediated drug-drug... 
SELECTIVE ANTAGONIST | ANGIOTENSIN-II AT1-RECEPTOR | PHARMACOKINETICS | LIVER | PHARMACOLOGY & PHARMACY | HEPATIC-UPTAKE | RENAL TRANSPORT | IDENTIFICATION | DRUG-DRUG INTERACTIONS | OATP1B1 | PREDICTION
Journal Article
Pharmacogenomics, ISSN 1462-2416, 07/2010, Volume 11, Issue 7, pp. 917 - 918
Journal Article
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 04/2011, Volume 54, Issue 4, pp. 738 - 745
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 05/2013, Volume 83, Issue 5, pp. 919 - 929
Organic anion-transporting polypeptides (OATPs) mediate the liver uptake and hence plasma clearance of a broad range of drugs. For rosuvastatin, a... 
DRUG | PHARMACOKINETICS | METABOLISM | PHARMACOLOGY & PHARMACY | MICE | HEPATIC-UPTAKE | OATP1B1 | POLYPEPTIDES | DISPOSITION | BIOAVAILABILITY | ATORVASTATIN
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2015, Volume 32, Issue 6, pp. 1864 - 1883
To develop a population physiologically-based pharmacokinetic (PBPK) model for simvastatin (SV) and its active metabolite, simvastatin acid (SVA), that allows... 
Biochemistry, general | Biomedical Engineering | drug-drug interactions | Biomedicine | Pharmacy | PBPK | simvastatin | Medical Law | population model | Pharmacology/Toxicology | OATP1B1 | HYDROXY ACID | VARIANTS | DRUG-INTERACTIONS | "simvastatin" | QUANTIFICATION | IN-VITRO DATA | "population model" | "OATP1B1" | STATINS | CHEMISTRY, MULTIDISCIPLINARY | DISPOSITION | PRIOR DISTRIBUTIONS | "PBPK" | PHARMACOLOGY & PHARMACY | "drug-drug interactions" | PRAVASTATIN | INHIBITORS | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Activation, Metabolic | Cytochrome P-450 Enzyme Inhibitors - therapeutic use | Simvastatin - adverse effects | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Biological Availability | Muscle, Skeletal - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Healthy Volunteers | Simvastatin - blood | Organic Anion Transporters - metabolism | Tissue Distribution | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | Drug Interactions | Liver - drug effects | Muscle, Skeletal - drug effects | Muscular Diseases - chemically induced | Pharmacogenetics | Reproducibility of Results | Simvastatin - chemistry | Muscular Diseases - metabolism | Simvastatin - administration & dosage | Liver - metabolism | Simvastatin - pharmacokinetics | Simvastatin - analogs & derivatives | Polymorphism, Genetic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Models, Biological | Solute Carrier Organic Anion Transporter Family Member 1b1 | Metabolites | Simvastatin | Drug interactions | Liver | Cytochrome P-450 | Antilipemic agents | Side effects | Pharmacology | Kinetics | Statins | Index Medicus
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2019, Volume 378, pp. 114642 - 114642
Organic anion transporting polypeptides (OATPs) are key players of drug absorption, distribution and excretion due to their broad substrate specificity, wide... 
Uptake function | Protein stability | Transmembrane domains | Organic anion transporting polypeptides | Amino-terminus | ACID-RESIDUES | DISPOSITION | OATP1B1 | KINETICS | ESTRONE-3-SULFATE | SUPERFAMILY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | BINDING | DRUG-DRUG INTERACTIONS
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 05/2012, Volume 53, Issue 5, pp. 741 - 748
Journal Article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 08/2019, Volume 67, Issue 32, pp. 9079 - 9087
Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are two highly homologous transporters expressed in the human liver. However, epigallocatechin... 
PROTEIN | epigallocatechin gallate | FOOD SCIENCE & TECHNOLOGY | OATP | RIFAMPICIN | chimera | INHIBITION | transmembrane domain | transporter | HEPATIC-UPTAKE TRANSPORTERS | DRUGS | AGRICULTURE, MULTIDISCIPLINARY | SUPERFAMILY | CHEMISTRY, APPLIED | activation | EXPRESSION | HUMAN OATP1B1 | Index Medicus
Journal Article
by Li, Rui
The AAPS Journal, ISSN 1550-7416, 7/2019, Volume 21, Issue 4, pp. 1 - 8
A reasonable estimate on the fractional contribution of transporters to total hepatic active uptake (F T ) is a critical factor in understanding and predicting... 
Biochemistry, general | modeling and simulation | Biotechnology | fractional contribution | Biomedicine | hepatic transporter | Pharmacy | Pharmacology/Toxicology | OATP1B1 | pharmacogenetics | Pharmacogenetics | Models | Analysis | Genetic polymorphisms
Journal Article
Xenobiotica, ISSN 0049-8254, 10/2019, Volume 49, Issue 10, pp. 1221 - 1228
Radix Ophiopogonis is often an integral part of many traditional Chinese formulas, such as Shenmai injection used to treat cardio-cerebrovascular diseases.... 
methylophiopogonanone B | OATP1B3 | Ophiopogonin D | methylophiopogonanone A | OATP1B1 | interactions | POLYPEPTIDES | DISPOSITION | FAMILY | IMPACT | PHARMACOKINETICS | HEPATIC-UPTAKE TRANSPORTERS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DRUG-DRUG INTERACTIONS
Journal Article
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