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alpha-ketoglutarate-dependent dioxygenase fto (57) 57
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oxidative demethylation (24) 24
alleles (22) 22
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genetic research (21) 21
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rna, messenger - metabolism (19) 19
single nucleotide polymorphisms (19) 19
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alpha-ketoglutarate-dependent dioxygenase fto - genetics (18) 18
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n6-methyladenosine (15) 15
physical-activity (15) 15
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rs9939609 (15) 15
adenosine - analogs & derivatives (14) 14
adenosine - metabolism (14) 14
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by Qi, Qibin and Kilpeläinen, Tuomas O and Downer, Mary K and Tanaka, Toshiko and Smith, Caren E and Sluijs, Ivonne and Sonestedt, Emily and Chu, Audrey Y and Renström, Frida and Lin, Xiaochen and Ängquist, Lars H and Huang, Jinyan and Liu, Zhonghua and Li, Yanping and Asif Ali, Muhammad and Xu, Min and Ahluwalia, Tarunveer S.ingh and Boer, Jolanda M. A and Chen, Peng and Daimon, Makoto and Eriksson, Johan and Perola, Markus and Friedlander, Yechiel and Gao, Yu-Tang and Heppe, Denise H. M and Holloway, John W and Houston, Denise K and Kanoni, Stavroula and Kim, Yu-Mi and Laaksonen, Maarit A and Jääskeläinen, Tiina and Lee, Nanette R and Lehtimäki, Terho and Lemaitre, Rozenn N and Lu, Wei and Luben, Robert N and Manichaikul, Ani and Männistö, Satu and Marques-Vidal, Pedro and Monda, Keri L and Ngwa, Julius S and Perusse, Louis and van Rooij, Frank J. A and Xiang, Yong-Bing and Wen, Wanqing and Wojczynski, Mary K and Zhu, Jingwen and Borecki, Ingrid B and Bouchard, Claude and Cai, Qiuyin and Cooper, Cyrus and Dedoussis, George V and Deloukas, Panos and Ferrucci, Luigi and Forouhi, Nita G and Hansen, Torben and Christiansen, Lene and Hofman, Albert and Johansson, Ingegerd and Jørgensen, Torben and Karasawa, Shigeru and Khaw, Kay-Tee and Kim, Mi-Kyung and Kristiansson, Kati and Li, Huaixing and Lin, Xu and Liu, Yongmei and Lohman, Kurt K and Long, Jirong and Mikkilä, Vera and Mozaffarian, Dariush and North, Kari and Pedersen, Oluf and Raitakari, Olli and Rissanen, Harri and Tuomilehto, Jaakko and van der Schouw, Yvonne T and Uitterlinden, André G and Zillikens, M Carola and Franco, Oscar H and Shyong Tai, E and Ou Shu, Xiao and Siscovick, David S and Toft, Ulla and Verschuren, W M Monique and Vollenweider, Peter and Wareham, Nicholas J and Witteman, Jacqueline C. M and Zheng, Wei and Ridker, Paul M and Kang, Jae H and Liang, Liming and Jensen, Majken K and Curhan, Gary C and Pasquale, Louis R and Hunter, David J and Mohlke, Karen L and Uusitupa, Matti and Cupples, L Adrienne and Rankinen, Tuomo and ... and Medicinska fakulteten and Institutionen för odontologi and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Human molecular genetics, ISSN 0964-6906, 12/2014, Volume 23, Issue 25, pp. 6961 - 6972
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2012, Volume 134, Issue 43, pp. 17963 - 17971
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the... 
OBESITY-ASSOCIATED FTO | OXIDATIVE DEMETHYLATION | COMMON VARIANT | ESCHERICHIA-COLI | CRYSTAL-STRUCTURES | REPAIR ENZYME ALKB | NUCLEIC-ACID DEMETHYLASE | ADULT OBESITY | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | FAT MASS
Journal Article
by Fu, Y and Jia, GF and Pang, XQ and Wang, RN and Wang, X and Li, CJ and Smemo, S and Dai, Q and Bailey, KA and Nobrega, MA and Han, KL and Cui, Q and He, C
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2013, Volume 4
N-6-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery... 
OBESITY-ASSOCIATED FTO | MESSENGER-RNA | GENE | OXIDATIVE DEMETHYLATION | DNA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | 5-HYDROXYMETHYLCYTOSINE | ALKB | ADULT OBESITY | 5-CARBOXYLCYTOSINE
Journal Article
Human Genetics, ISSN 0340-6717, 11/2015, Volume 134, Issue 11, pp. 1183 - 1193
Journal Article
CHEMICAL SCIENCE, ISSN 2041-6520, 09/2018, Volume 9, Issue 36, p. 7174
N-6-Methyladenosine (m(6)A) is one of the most abundant epigenetic modifications on mRNA. It is dynamically regulated by the m(6)A demethylases FTO and ALKBH5,... 
OBESITY-ASSOCIATED FTO | STEM-CELLS | ALKBH5 | MESSENGER-RNA | GENE | STRUCTURAL BASIS | STABILITY | MA RNA METHYLATION | NUCLEAR-RNA | CHEMISTRY, MULTIDISCIPLINARY | ALKYLATION DAMAGE
Journal Article
by Huang, Y and Yan, JL and Li, Q and Li, JF and Gong, SZ and Zhou, H and Gan, JH and Jiang, HL and Jia, GF and Luo, C and Yang, CG
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 01/2015, Volume 43, Issue 1, pp. 373 - 384
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N-6-methyladenosine (m(6)A) residues in... 
RNA DEMETHYLASE | OBESITY-ASSOCIATED FTO | MAXIMUM-LIKELIHOOD | MESSENGER-RNA | OXIDATIVE DEMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | PROMOTE PROTEIN STABILITY | CRYSTAL-STRUCTURES | HISTONE DEMETHYLASES | ALKYLATION DAMAGE
Journal Article
Diabetes, ISSN 0012-1797, 07/2015, Volume 64, Issue 7, pp. 2467 - 2476
Journal Article