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Ecotoxicology and Environmental Safety, ISSN 0147-6513, 10/2019, Volume 182, p. 109377
The measurement of oxygen consumption rate (OCR) provides a comprehensive understanding of mitochondrial metabolism. However, no study has been conducted to... 
Zebrafish | Mitochondria | TDCIPP | Oxygen consumption rate (OCR) | TPHP | BEHAVIOR | CARDIOTOXICITY | TOXICITY | TDCPP | PHOSPHATE | ENVIRONMENTAL SCIENCES | METABOLISM | BIOENERGETICS | IN-VIVO | MITOCHONDRIAL DYSFUNCTION | TOXICOLOGY | EXPRESSION
Journal Article
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN 1940-087X, 02/2019, Issue 144
Optimal mitochondrial function is critical for healthy cellular activity, particularly in cells that have high energy demands like those in the nervous system... 
LIFE-SPAN | C. elegans | mitochondria | CALCIUM HOMEOSTASIS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL-FUNCTION | Biology | respiration | respirometer | Issue 144 | oxygen consumption rate (OCR) | metabolism | FUDR
Journal Article
Mitochondrion, ISSN 1567-7249, 01/2019, Volume 44, pp. 65 - 74
We evaluated plasma glutamine levels and basal mitochondrial oxygen consumption rate (mOCR ) and basal extracellular acidification rate (ECAR ) of peripheral... 
Oxygen consumption rate (OCR) | Peripheral blood mononuclear cells (PBMCs) | Extracellular acidification rate (ECAR) | Systemic lupus erythematous (SLE) | Glutamine | CRITERIA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CLASSIFICATION | MITOCHONDRIAL-DNA | CELL BIOLOGY | HYPERGLYCEMIA | LEUKOCYTES | BIOGENESIS | METABOLISM | GENETICS & HEREDITY | DYSFUNCTION | EXPRESSION
Journal Article
Indian Journal of Marine Sciences, ISSN 0379-5136, 10/2012, Volume 41, Issue 5, pp. 468 - 472
Oxygen consumption rate (OCR) of the estuarine clam, Soletellina diphos (Linnaeus) was studied in the laboratory. The OCR was measured against a range of body... 
Soletellina diphos | Oxygen consumption rate (OCR) | Environmental conditions | ENERGY-BALANCE | TEMPERATURE | environmental conditions | OCEANOGRAPHY | oxygen consumption rate (OCR)
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2014, Volume 462, Issue 3, pp. 475 - 487
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of... 
ATP synthase | Complex I | Biguanide | Metformin | Reactive oxygen species (ROS) | Nadh:quinone oxidoreductase | CELLS | FLAVIN | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NADH:quinone oxidoreductase | biguanide | metformin | reactive oxygen species (ROS) | RAT-LIVER MITOCHONDRIA | HEART | NADH | INHIBITION | METABOLISM | OXIDOREDUCTASE COMPLEX-I | PURIFICATION | complex I | Biguanides - pharmacology | Triazines - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Metformin - therapeutic use | Biguanides - therapeutic use | Humans | Metformin - pharmacology | Rats | Plasmodium - drug effects | Mitochondria, Heart - drug effects | Electron Transport Complex I - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Antimalarials - pharmacology | Hep G2 Cells | Mitochondria, Liver - drug effects | Oxidative Phosphorylation - drug effects | Animals | Reperfusion Injury - prevention & control | Cattle | Antineoplastic Agents - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Mitochondrial Proton-Translocating ATPases - antagonists & inhibitors | Proguanil - pharmacology | SMP, submitochondrial particle | HAR, hexaammineruthenium(III) | OCR, oxygen consumption rate | AMPK, AMP-activated protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | ECAR, extracellular acidification rate | FeCN, ferricyanide | ROS, reactive oxygen species | OCT1, organic cation transporter 1
Journal Article
Chemosphere, ISSN 0045-6535, 02/2020, Volume 240, p. 124974
In this research, the continuous physiological changes of zebrafish ( ) in 0.1 μg/L thallium (Tl) in 15 days were investigated. The results showed that Tl(I)... 
Ammonia nitrogen excretion (ANE) | Ammonia quotient (AQ) | Environmental risk assessment | Oxygen consumption rate (OCR) | Zebrafish (Danio rerio)
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | MECHANISMS | IMMUNOLOGY | FRAGMENTATION | HYPERRESPONSIVENESS | BETA | RESPONSES | ALLERGY | ENERGY-METABOLISM | EXPRESSION | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2018, Volume 92, Issue 17
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, Issue Pt B, pp. 417 - 426
In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related... 
Xanthohumol | Nrf2 | ER stress | AMPK | HO-1 | PERK | LKB1 | MEF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MECHANISMS | ENERGY SENSOR | CELL DEFENSE PATHWAY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | NRF2-MEDIATED INDUCTION | HEME OXYGENASE-1 | STRESS | AMP-Activated Protein Kinases - metabolism | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress - physiology | Propiophenones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Cross-Talk - physiology | Blotting, Western | Animals | Flow Cytometry | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Mice | Real-Time Polymerase Chain Reaction | Unfolded Protein Response - physiology | Fibroblasts - metabolism | RNA | Glycogen | Synthesis | ACC, acetyl-CoA carboxylase | CHO, Chinese hamster ovary | GSH, glutathione (reduced) | OCR, oxygen consumption rate | HO-1, heme oxygenase 1 | CaMKK, calcium calmodulin-dependent kinase kinase | Maf, small musculoaponeurotic fibrosarcoma | PERK, protein kinase RNA-like endoplasmic reticulum kinase | Xn, xanthohumol | Hrd1, synoviolin | TAK, transforming growth factor β-activated kinase | UPR, unfolded protein response | Hrd1 (HMG-CoA reductase degradation)-ubiquitin ligase | MEF, mouse embryonic fibroblasts | βTrcP1, β-transducin-repeat containing protein 1 | mTOR, mammalian target of rapamycin | ROS, reactive oxygen species | LKB1, liver kinase B1 | Keap1, Kelch-like ECH-associated protein | GSSG, oxidized glutathione | ARE, antioxidant response element | WT, wild type | GSK3β, glycogen synthase kinase 3β | Nrf2, nuclear factor E2-related factor 2 | AMPK, AMP-activated kinase | DCF, dichlorofluorescein | NADPH, nicotinamide adenine dinucleotide phosphate | DMSO, dimethyl sulfoxide | ER, endoplasmic reticulum | FCS, fetal calf serum
Journal Article
Redox Biology, ISSN 2213-2317, 2013, Volume 1, Issue 1, pp. 86 - 93
Mitochondria are recognized as critical sites of localized injury in a number of chronic pathologies which has led to the development of organelle directed... 
Extracellular flux | Mitochondria | TPP+ derivatives | MitoQ | Redox | Respiration | Mitochondrial targeted compounds | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
Frontiers in physiology, ISSN 1664-042X, 2018, Volume 9, p. 747
The involvement of mitochondrial uncoupling proteins 2 and 3 in the pathogenesis of cardiovascular diseases is widely acknowledged. However, contradictory... 
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2016, Volume 91, pp. 281 - 292
The caseinolytic peptidase P (ClpP) is the endopeptidase component of the mitochondrial matrix ATP-dependent ClpXP protease. ClpP degrades unfolded proteins to... 
ClpX | ClpP | Reactive oxygen species | Respiration | Mitochondrial unfolded protein response | Mitochondrial fission/fusion | ECAR extracellular acidification rate | GCN2 general control nonderepressible 2 | DMEM Dulbecco's modified Eagle's medium | hydrogen peroxide | Hsp60 heat shock protein 60 | shRNA short hairpin RNA | Abbreviations ClpP caseinolytic peptidase P | PKR protein kinase R | TFAM mitochondrial transcription factor A | mitochondrial unfolded protein response | FCCP carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone | ROS reactive oxygen species | ETC electron transport chain | OCR oxygen consumption rate | DOX doxycycline | Mfn mitofusin | MHC myosin heavy chain | UPR | mtDNA mitochondrial DNA | PINK1 phosphatase and tensin homolog-induced kinase 1 | eIF2α eukaryotic initiation factor 2 alpha | QC quality control | Cell Line | Protein Biosynthesis | Cell Proliferation | Mitochondria, Muscle - enzymology | Down-Regulation | Endopeptidase Clp - metabolism | Unfolded Protein Response | Hydrogen Peroxide - metabolism | Animals | Cell Shape | Electron Transport Chain Complex Proteins - metabolism | Membrane Potential, Mitochondrial | Glycolysis | Myoblasts - ultrastructure | Mitochondria, Muscle - ultrastructure | Cell Differentiation | Mice | Myoblasts - physiology | Proteins | Physiological aspects | Cell differentiation | Proteases | Cells | fusion | Mitochondrial fission
Journal Article