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1. Full Text Oleanolic acid
by Pollier, Jacob and Goossens, Alain
Phytochemistry, ISSN 0031-9422, 05/2012, Volume 77, pp. 10 - 15
Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound with various pharmacological activities and a widespread occurrence... 
Saponins | GC–MS | Hepatoprotective | CDDO-Me | Nrf2 | Synthetic triterpenes | Anticancer | Anti-inflammatory | Bardoxolone methyl | Oleanolic acid | GC-MS | OLEA-EUROPAEA OLEACEAE | BILE-ACID | BETA-AMYRIN SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MASS-SPECTROMETRY | PLANT SCIENCES | PERFORMANCE LIQUID-CHROMATOGRAPHY | URSOLIC ACID | NITRIC-OXIDE PRODUCTION | PENTACYCLIC TRITERPENES | FARNESOID-X-RECEPTOR | MOUSE MACROPHAGES | Humans | Oleanolic Acid - analogs & derivatives | Cells, Cultured | Oleanolic Acid - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Protective Agents - chemistry | Antineoplastic Agents, Phytogenic - biosynthesis | Plants - metabolism | Liver - drug effects | Oleanolic Acid - biosynthesis | Protective Agents - pharmacology | Oleanolic Acid - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Terpenes
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2. Full Text Oleanolic acid and ursolic acid: Research perspectives
by Liu, Jie
Journal of Ethnopharmacology, ISSN 0378-8741, 2005, Volume 100, Issue 1, pp. 92 - 94
Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet. During the last decade... 
Toxicology | Pharmacology | Oleanolic acid derivatives | Oleanolic acid | toxicology | APOPTOSIS | CHEMISTRY, MEDICINAL | PROTECTION | INTEGRATIVE & COMPLEMENTARY MEDICINE | oleanolic acid | pharmacology | PHARMACOLOGY & PHARMACY | INDUCTION | oleanolic acid derivatives | PLANT SCIENCES | Triterpenes - chemistry | Animals | Triterpenes - pharmacology | Humans | Oleanolic Acid - chemistry | Oleanolic Acid - pharmacology | Medicine, Traditional | Plants, Medicinal | Medicine, Botanic | Medicine, Herbal
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3. Full Text Antioxidative and antiinflammatory activities of asiatic acid, glycyrrhizic acid, and oleanolic acid in human bronchial epithelial cells
by Tsao, Shih-Ming and Yin, Mei-Chin
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 04/2015, Volume 63, Issue 12, pp. 3196 - 3204
Protective effects of triterpenic acids, asiatic acid (AA), glycyrrhizic acid (GA), or oleanolic acid (OA), for two human bronchial epithelial cells, 16HBE and... 
NF-κB | bronchial epithelial cells | MAPK | ROS | triterpenic acids | APOPTOSIS | OXIDATIVE STRESS | TRITERPENOIDS | FOOD SCIENCE & TECHNOLOGY | INVOLVEMENT | INJURY | URSOLIC ACID | LUNG-CANCER | NF-kappa B | AGRICULTURE, MULTIDISCIPLINARY | CIGARETTE-SMOKE | HYDROGEN-PEROXIDE | CHEMISTRY, APPLIED | NF-KAPPA-B | Hydrogen Peroxide - toxicity | Cell Line | Reactive Oxygen Species | Anti-Inflammatory Agents - pharmacology | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Oleanolic Acid - pharmacology | Pentacyclic Triterpenes - pharmacology | Antioxidants - pharmacology | Bronchi - immunology | Bronchi - drug effects | Glycyrrhizic Acid - pharmacology | Epithelial Cells - immunology | Epithelial Cells - cytology | Bronchi - cytology
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4. Full Text Complete assignments of 1H and 13C NMR resonances of oleanolic acid, 18α‐oleanolic acid, ursolic acid and their 11‐oxo derivatives
by Seebacher, Werner and Simic, Nebojsa and Weis, Robert and Saf, Robert and Kunert, Olaf
Magnetic Resonance in Chemistry, ISSN 0749-1581, 08/2003, Volume 41, Issue 8, pp. 636 - 638
Complete assignments of 1H and 13C NMR chemical shifts for oleanolic acid, 18α‐oleanolic acid, ursolic acid and their 11‐oxo derivatives based on 1H, 13C, 2D... 
NMR | 11‐oxo‐18α‐oleanolic acid | 11‐oxoursolic acid | 2D NMR | oleanolic acid | 18α‐oleanolic acid | 1H NMR | 13C NMR | 11‐oxooleanolic acid | ursolic acid | 11-oxoursolic acid | 18α-oleanolic acid | C NMR | Ursolic acid | 11-oxo-18α-oleanolic acid | 11-Oxooleanolic acid | H NMR | Oleanolic acid
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5. Full Text Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation
by Kim, Joo-Hyun and Kim, Dong-Eun and Kim, Young Ho and Song, Gyu-Yong and Jeong, Yong-Joo and Liu, Kwang-Hyeon and Chung, Young-Hwa and Oh, Sangtaek
Food and Chemical Toxicology, ISSN 0278-6915, 05/2014, Volume 67, pp. 87 - 95
Ursolic acid (UA) and corosolic acid (CA), naturally occurring pentacyclic triterpene acids, exhibit antiproliferative activities against various cancer cells,... 
Wnt/β-catenin signaling | Protein degradation | Ursolic acid | Colon cancer | Corosolic acid | APOPTOSIS | ACTIVATION | CYCLIN D1 | FOOD SCIENCE & TECHNOLOGY | KINASE | DOWN-REGULATION | FACTOR-KAPPA-B | Wnt/beta-catenin signaling | OLEANOLIC ACID | IN-VITRO | INHIBITION | PATHWAY | TOXICOLOGY | Hydrolysis | Phosphorylation | Triterpenes - pharmacology | Humans | HEK293 Cells | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | beta Catenin - metabolism | Genes, APC | Index Medicus | Degradation | Genes | Foods | Derivatives | Colon | Promotion | Cancer
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6. Full Text Anti-AIDS agents 81. design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors
by Qian, Keduo and Kuo, Reen-Yun and Chen, Chin-Ho and Huang, Li and Morris-Natschke, Susan L and Lee, Kuo-Hsiung
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3133 - 3141
In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were... 
CHEMISTRY, MEDICINAL | THERAPY | PHARMACOKINETICS | SAFETY | BEVIRIMAT | PA-457 | RESISTANCE | INFECTION | STEP | HEALTHY-VOLUNTEERS | HUMAN-IMMUNODEFICIENCY-VIRUS | Anti-HIV Agents - pharmacology | Cell Line | Virus Replication - drug effects | Triterpenes - pharmacology | HIV-1 - drug effects | Stereoisomerism | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - chemical synthesis | Virion - physiology | Oleanolic Acid - pharmacology | Structure-Activity Relationship | HIV-1 - genetics | Anti-HIV Agents - chemical synthesis | Virion - drug effects | Anti-HIV Agents - chemistry | Triterpenes - chemistry | HIV-1 - physiology | Triterpenes - chemical synthesis | Drug Design | Oleanolic Acid - chemistry | Mutation
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7. Full Text Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase
by Ding, Huafang and Hu, Xing and Xu, Ximing and Zhang, Guowen and Gong, Deming
International Journal of Biological Macromolecules, ISSN 0141-8130, 02/2018, Volume 107, Issue Pt B, pp. 1844 - 1855
Glycemic control which can be efficaciously regulated by inhibiting α-glucosidase activity is an effective therapy for diabetes mellitus. This work is to... 
α-Glucosidase | Pentacyclic triterpenes | Inhibition mechanism | POLYMER SCIENCE | BINDING MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR DOCKING | IN-VITRO | XANTHINE-OXIDASE | KINETICS | AMYLASE | alpha-Glucosidase | CHEMISTRY, APPLIED | DERIVATIVES | BOVINE SERUM-ALBUMIN | STARCH DIGESTION | EXTRACT | Acarbose - pharmacology | Allosteric Regulation - drug effects | Triterpenes - pharmacology | Oleanolic Acid - pharmacology | Spectrometry, Fluorescence | Enzyme Activation - drug effects | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | Acarbose - chemistry | Molecular Dynamics Simulation | Thermodynamics | Triterpenes - chemistry | Time Factors | Allosteric Site | Oleanolic Acid - chemistry | Saccharomyces cerevisiae - enzymology | Kinetics | Circular Dichroism
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8. Full Text Antioxidative and Anti‐Inflammatory Protection of Oleanolic Acid and Ursolic Acid in PC12 Cells
by Tsai, Shih‐Jei and Yin, M.‐C
Journal of Food Science, ISSN 0022-1147, 09/2008, Volume 73, Issue 7, pp. H174 - H178
PC12 cells were used to examine the in vitro antioxidative and anti‐inflammatory effects of oleanolic acid (OA) and ursolic acid (UA). PC12 cells were... 
antiinflammatory | antioxidative | oleanolic acid | PC12 cells | ursolic acid | Ursolic acid | Antioxidative | Antiinflammatory | Oleanolic acid | FRUITS | OXIDATIVE STRESS | FOOD SCIENCE & TECHNOLOGY | DEATH | NEUROTOXICITY | DAMAGE | INFLAMMATION | MPTP | STRIATUM | EXPOSURE | PARKINSONS-DISEASE | L-Lactate Dehydrogenase - metabolism | Malondialdehyde - metabolism | Tumor Necrosis Factor-alpha - metabolism | Glutathione Peroxidase - metabolism | Triterpenes - pharmacology | Oxidative Stress | Anti-Inflammatory Agents - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacology | Hydrogen Peroxide - pharmacology | Oleanolic Acid - pharmacology | Rats | Antioxidants - pharmacology | PC12 Cells | Catalase - metabolism | Animals | Lipid Peroxidation - drug effects | Cell Death - drug effects | Interleukin-6 - metabolism | Superoxide Dismutase - metabolism | Pyridinium compounds | Hydrogen peroxide | Chemical properties | Research | Oleic acid
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9. Full Text Development and validation of an analytical method based on HPLC-ELSD for the simultaneous determination of rosmarinic acid, carnosol, carnosic acid, oleanolic acid and ursolic acid in rosemary
by Li, Penghui and Liu, Ailing and Li, Yinhua and Yuan, Bin and Xiao, Wenjun and Liu, Zhonghua and Zhang, Sheng and Lin, Haiyan
Molecules, ISSN 1420-3049, 01/2019, Volume 24, Issue 2, p. 323
The safety, efficacy and stability of natural antioxidants have been the focus of research in the food industry, with the aim of rapidly analyzing and... 
HPLC-ELSD | Carnosic acid | Rosemary | Rosmarinic acid | Ursolic acid | Carnosol | Oleanolic acid | carnosol | carnosic acid | oleanolic acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | rosmarinic acid | CHEMISTRY, MULTIDISCIPLINARY | ursolic acid | rosemary | ANTIOXIDANT | IN-VIVO | SALVIA-OFFICINALIS | EXTRACTS
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10. Full Text Solubilities of oleanolic acid and ursolic acid in (ethanol + water) mixed solvents from T = (292.2 to 328.2) K
by Fan, Jie-Ping and Kong, Tao and Zhang, Xue-Hong and Zhang, Lu and Tong, Sheng and Tian, Zhe-You and Zhu, Jian-Hang
The Journal of Chemical Thermodynamics, ISSN 0021-9614, 2012, Volume 47, pp. 372 - 375
► The solubilities of OA and UA in (ethanol + water) mixed solvents are measured. ► The experimental solubility data are correlated by two equations. ► The... 
Solvents | Correlation | Ursolic acid | Solubility | Oleanolic acid | DIHEXAFLUOROPHOSPHATE | METHANOL | ACETONE | CHEMISTRY, PHYSICAL | BETULIN | MIXTURES | THERMODYNAMICS | DIFFERENT TEMPERATURES | ACETONITRILE | RUTIN | Alcohol | Alcohol, Denatured | Chemical properties | Thermodynamics | Ethanol | Mathematical analysis | Ethyl alcohol | Moles
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11. Full Text Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells
by Takada, K and Nakane, T and Masuda, K and Ishii, H
Phytomedicine, ISSN 0944-7113, 2010, Volume 17, Issue 14, pp. 1114 - 1119
E-selectin is an early response adhesion molecule expressed on the surface of endothelial cells during inflammatory responses. We examined the effects of two... 
Triterpenoid acids | E-selectin | NF-κB | Ursolic acid | Endothelial cells | Oleanolic acid | ACTIVATION | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | PHOSPHORYLATION | PLANT SCIENCES | NF-kappa B | INHIBITION | INTEGRATIVE & COMPLEMENTARY MEDICINE | 12-O-TETRADECANOYLPHORBOL-13-ACETATE | MATRIX-METALLOPROTEINASE-9 | PHARMACOLOGY & PHARMACY | BINDING | MMP-9 | MODULATION | Arctostaphylos - chemistry | Endothelium, Vascular - cytology | Tumor Necrosis Factor-alpha - metabolism | Plant Extracts - chemistry | Triterpenes - pharmacology | Plant Extracts - pharmacology | Humans | Plant Leaves | Magnoliopsida - chemistry | Oleanolic Acid - pharmacology | RNA, Messenger - metabolism | Plant Extracts - administration & dosage | Plant Roots | E-Selectin - genetics | Antigens, Surface - metabolism | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - isolation & purification | Oleanolic Acid - isolation & purification | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Cells, Cultured | Umbilical Veins | E-Selectin - metabolism | Oleanolic Acid - administration & dosage | Panax - chemistry | Endothelium, Vascular - metabolism | Triterpenes - isolation & purification | NF-kappa B - pharmacology | Triterpenes - administration & dosage
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12. Full Text Low Dose of Oleanolic Acid Protects against Lithocholic Acid-Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins
by Chen, P and Zeng, H and Wang, YT and Fan, XM and Xu, CS and Deng, RR and Zhou, XN and Bi, HC and Huang, M
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 05/2014, Volume 42, Issue 5, pp. 844 - 852
Oleanolic acid (OA) is a natural triterpenoid and has been demonstrated to protect against varieties of hepatotoxicants. Recently, however, OA at high doses... 
BILE-ACID | ENHANCER MODULE | LIVER CELL-CULTURE | INTRAHEPATIC CHOLESTASIS | CONSTITUTIVE ANDROSTANE RECEPTOR | GENE-EXPRESSION | INJURY | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | PREGNANE-X-RECEPTOR | INDUCED HEPATOTOXICITY | Liver Function Tests | Chemical and Drug Induced Liver Injury - prevention & control | Up-Regulation | Cholestasis - metabolism | Gene Expression - drug effects | Humans | Mice, Inbred C57BL | Male | NF-E2-Related Factor 2 - agonists | Hepatocytes - metabolism | Cholestasis - chemically induced | Hep G2 Cells | Dose-Response Relationship, Drug | Oleanolic Acid - administration & dosage | Animals | Cholestasis - prevention & control | Lithocholic Acid - pharmacology | Chemical and Drug Induced Liver Injury - metabolism | NF-E2-Related Factor 2 - metabolism | Multidrug Resistance-Associated Proteins - genetics | Mice | Oleanolic Acid - therapeutic use | Primary Cell Culture | Hepatocytes - drug effects | Index Medicus
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13. Full Text Ursolic acid (UA): A metabolite with promising therapeutic potential
by Kashyap, Dharambir and Tuli, Hardeep Singh and Sharma, Anil K
Life Sciences, ISSN 0024-3205, 02/2016, Volume 146, pp. 201 - 213
Plants are known to produce a variety of bioactive metabolites which are being used to cure various life threatening and chronic diseases. The molecular... 
Ursolic acid | Derivatives | Anti-metastasis | Anti-oxidant | Anti-inflammatory | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | DOWN-REGULATION | CYTOTOXIC ACTIVITY | OLEANOLIC ACID | ANTICANCER ACTIVITY | IN-VITRO | PROSTATE-CANCER CELLS | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | KAPPA-B PATHWAY | INHIBITS PROLIFERATION | EARLY BRAIN-INJURY | Triterpenes - chemistry | Animals | Humans | Triterpenes - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Triterpenes - adverse effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neoplasms - pathology | Antineoplastic Agents, Phytogenic - adverse effects | Neoplasms - drug therapy | Metabolites | Health aspects
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14. Full Text Simultaneous determination and quantification of three pentacyclic triterpenoids—betulinic acid, oleanolic acid, and ursolic acid—in cell cultures of Lantana camara L
by Srivastava, Priyanka and Chaturvedi, Rakhi
In Vitro Cellular & Developmental Biology - Plant, ISSN 1054-5476, 12/2010, Volume 46, Issue 6, pp. 549 - 557
A simple procedure has been described for simultaneous determination and improved yield of three pentacyclic triterpenoids—betulinic, oleanolic, and ursolic... 
Life Sciences | Leaf cultures | RP-HPLC | Plant Breeding/Biotechnology | Betulinic acid | Ursolic acid | Developmental Biology | Plant Sciences | Mass spectrometry | Plant Genetics & Genomics | Cell Biology | Oleanolic acid | DEVELOPMENTAL BIOLOGY | DERIVATIVES | PROPAGATION | PLANT SCIENCES | CELL BIOLOGY | Nitriles | Liquid chromatography | Ionization | Metabolites | Acids | Ethanol | Natural products
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15. Full Text Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment
by Salvador, Jorge A.R and Leal, Ana S and Valdeira, Ana S and Gonçalves, Bruno M.F and Alho, Daniela P.S and Figueiredo, Sandra A.C and Silvestre, Samuel M and Mendes, Vanessa I.S
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2017, Volume 142, pp. 95 - 130
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of biological activities. Among them, the anticancer and... 
Semisynthetic derivatives | Pentacyclic triterpenoids | Structure-activity relationship | Cancer | CDDO-METHYL ESTER | CHEMISTRY, MEDICINAL | CELL-CYCLE ARREST | ENDOPLASMIC-RETICULUM STRESS | ASIATIC ACID | OLEANOLIC ACID | NITRIC-OXIDE PRODUCTION | GLYCYRRHETINIC ACID | BIOLOGICAL EVALUATION | ANTITUMOR-ACTIVITY EVALUATION | URSOLIC ACID-DERIVATIVES | Chemistry Techniques, Synthetic | Triterpenes - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - chemical synthesis | Triterpenes - therapeutic use | Indolequinones - chemical synthesis | Indolequinones - pharmacology | Oleanolic Acid - pharmacology | Antineoplastic Agents - therapeutic use | Indolequinones - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Triterpenes - chemistry | Animals | Triterpenes - chemical synthesis | Indolequinones - therapeutic use | Oleanolic Acid - chemistry | Antineoplastic Agents - pharmacology | Oleanolic Acid - therapeutic use | Medicine, Experimental | Medical research | Care and treatment | Analysis | Quinone | Index Medicus
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