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otsuka long-evans tokushima fatty rat (62) 62
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Journal Article
Liver International, ISSN 1478-3223, 11/2012, Volume 32, Issue 10, pp. 1565 - 1573
Background Insulin resistance, oxidative stress, inflammation and innate immune system activation contribute to the development of non‐alcoholic fatty liver... 
non‐alcoholic fatty liver disease | α‐lipoic acid | diabetes | OLETF | obesity | Obesity | α-lipoic acid | Diabetes | Non-alcoholic fatty liver disease | a-lipoic acid | METABOLIC SYNDROME | OXIDATIVE STRESS | HEPATOCYTES | non-alcoholic fatty liver disease | ACTIVATED PROTEIN-KINASE | OBESE RATS | PATHOGENESIS | INSULIN-RESISTANCE | STEATOHEPATITIS | HEME OXYGENASE-1 | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Immunohistochemistry | Glucose Transporter Type 4 - metabolism | Cholesterol - blood | Aldehydes - metabolism | Insulin - blood | Leptin - blood | Interleukin-6 - blood | Azo Compounds | Lipid Peroxidation - drug effects | Non-alcoholic Fatty Liver Disease | Fatty Acids - blood | Sterol Regulatory Element Binding Protein 1 - metabolism | Immunity, Innate - drug effects | Liver - metabolism | Fatty Liver - prevention & control | Rats | Thioctic Acid - pharmacology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Adiponectin - blood | Gene Expression Regulation - drug effects | Rats, Inbred OLETF | Intercellular Adhesion Molecule-1 - metabolism | Animals | Cyclooxygenase 2 - metabolism | Fluorescent Antibody Technique | Triglycerides - blood | Blood Glucose - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Acetyl-CoA Carboxylase - metabolism | Thioctic Acid - therapeutic use
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 12/2016, Volume 51, Issue 12, pp. 1141 - 1149
It is widely understood that insulin resistance (IR) critically correlates with the development of liver fibrosis in several types of chronic liver injuries.... 
Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Insulin resistance | Liver fibrosis | Surgical Oncology | SGLT2 inhibitor | COLLAGEN | SGLT2 | MELLITUS | HEPATIC STELLATE CELLS | HYPERGLYCEMIA | STEATOSIS | INSULIN-RESISTANCE | C VIRUS-INFECTION | MAJOR REGULATOR | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Thiophenes - therapeutic use | Liver - pathology | Liver Cirrhosis, Experimental - etiology | Body Weight - drug effects | Male | Thiophenes - administration & dosage | Hepatic Stellate Cells - cytology | Dose-Response Relationship, Drug | Liver Cirrhosis, Experimental - prevention & control | Hypoglycemic Agents - administration & dosage | Insulin Resistance - physiology | Liver Cirrhosis, Experimental - pathology | Glucosides - therapeutic use | Diabetes Mellitus, Experimental - complications | Hepatic Stellate Cells - drug effects | Hypoglycemic Agents - therapeutic use | Drug Evaluation, Preclinical - methods | Obesity - complications | Cells, Cultured | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Rats, Inbred OLETF | Organ Size - drug effects | Animals | Glucosides - administration & dosage | Diabetes Mellitus, Experimental - pathology | Cell Proliferation - drug effects | Liver diseases | Liver | Fibrosis | Hypoglycemic agents | Glucose | Muscle proteins | Transforming growth factors | Dextrose
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 2017, Volume 232, Issue 3, pp. 501 - 511
Journal Article
The Journal of Physiology, ISSN 0022-3751, 09/2008, Volume 586, Issue 17, pp. 4241 - 4249
The purpose of this study was to delineate potential mechanisms initiating the onset of hepatic steatosis following the cessation of daily physical activity.... 
SKELETAL-MUSCLE | PHYSIOLOGY | DIET | METABOLISM | HYPERPHAGIA | GENETICALLY-OBESE | INCREASES | PHYSICAL-ACTIVITY | ACID OXIDATION | LIVER-DISEASE | CONTRIBUTES | NEUROSCIENCES | Rats, Inbred OLETF | Animals | Fatty Liver - metabolism | Oxidation-Reduction | Rats | Male | Time | Physical Conditioning, Animal - physiology | Fatty Acids - metabolism | Physiological aspects | Exercise | Synthesis | Fatty acids | Alimentary
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0165689
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2017, Volume 195, pp. 204 - 213
Hepatic steatosis has risen rapidly in parallel with a dramatic increase in obesity. The aim of this study was to determine whether the herbal composition... 
Peroxisome proliferator-activated receptor α | Fatty acid oxidation | Alnus japonica | Lipogenesis | Curcuma longa | Massa Medicata Fermentata | PPAR-ALPHA | ACTIVATION | CHEMISTRY, MEDICINAL | LIPID-METABOLISM | Peroxisome proliferator-activated receptor alpha | NONALCOHOLIC STEATOHEPATITIS | LIVER-DISEASE | MEDICINE | PLANT SCIENCES | PATHOGENESIS | OBESITY | INTEGRATIVE & COMPLEMENTARY MEDICINE | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TRANSGENIC MICE | Tyrosine - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Liver - enzymology | Plant Extracts - pharmacology | Humans | Hepatitis - blood | Male | Alanine Transaminase - blood | RNA, Messenger - metabolism | Obesity - genetics | Tyrosine - analogs & derivatives | Hepatitis - drug therapy | Non-alcoholic Fatty Liver Disease - blood | Fenofibrate - pharmacology | Transfection | Lipogenesis - genetics | Liver - drug effects | Hepatitis - genetics | Lipids - blood | Inflammation Mediators - metabolism | Hepatocytes - drug effects | Disease Models, Animal | Cytokines - metabolism | Non-alcoholic Fatty Liver Disease - genetics | Anti-Inflammatory Agents - pharmacology | RNA, Messenger - genetics | PPAR alpha - genetics | Biomarkers - blood | Hypolipidemic Agents - pharmacology | Hep G2 Cells | Non-alcoholic Fatty Liver Disease - drug therapy | Rats, Inbred OLETF | Animals | Lipogenesis - drug effects | Mice | Oxazoles - pharmacology | PPAR alpha - metabolism | Hepatocytes - enzymology | Immunohistochemistry | Monounsaturated fatty acids | Liver diseases | RNA | Liver | Triglycerides | Inflammation | Fermentation | Gene expression | Index Medicus
Journal Article
Journal Article