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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2012, Volume 12, Issue 14, pp. 1546 - 1552
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst <0.1% have been... 
Conopeptides | GPCR | Ion channels | CONTULAKIN-G | CHEMISTRY, MEDICINAL | CHI-CONOPEPTIDE | AMPA RECEPTOR | OMEGA-CONOTOXINS | INTERNATIONAL-UNION | ion channels | NEUROPATHIC PAIN | ALPHA-CONOTOXINS | UNION-OF-PHARMACOLOGY | OXYTOCIN RECEPTOR | CHANNEL BLOCKERS
Journal Article
by Liu, ZG and Bartels, P and Sadeghi, M and Du, TP and Dai, Q and Zhu, C and Yu, S and Wang, S and Dong, MX and Sun, T and Guo, JB and Peng, SQ and Jiang, L and Adams, DJ and Dai, QY
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2018, Volume 8
We here describe a novel alpha-conopeptide, Eu1.6 from Conus eburneus, which exhibits strong antin-ociceptive activity by an unexpected mechanism of action.... 
ACTIVATION | PAIN | RAT | ALPHA-9-ALPHA-10 | MULTIDISCIPLINARY SCIENCES | ZICONOTIDE | NACHR ALPHA-3-BETA-2 | DIVERSITY | NICOTINIC ACETYLCHOLINE-RECEPTORS | OMEGA-CONOTOXINS | CONUS-MARMOREUS
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3
SH-SY5Y human neuroblastoma cells provide a useful in vitro model to study the mechanisms underlying neurotransmission and nociception. These cells are derived... 
RECOMBINANT N-TYPE | RAT | FUNCTIONAL EXPRESSION | MULTIDISCIPLINARY SCIENCES | NEURONAL CALCIUM-CHANNEL | MIBEFRADIL BLOCK | GATED ION CHANNELS | OMEGA-CONOTOXINS | HIPPOCAMPAL-NEURONS | CA(V)2.2 | SUBUNIT
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, ISSN 0363-6119, 05/2018, Volume 314, Issue 5, pp. R693 - R699
mu-Opioid G protein-coupled receptors (MOR) interact with ion channels to decrease neuronal excitability. In humans. intrathecal administration of the MOR... 
heart rate | PHYSIOLOGY | GIRK channels | IV MUSCLE AFFERENTS | circulatory control | SUBSTANCE-P RELEASE | MORPHINE | sympathetic nervous system | GATED POTASSIUM CHANNELS | GROUP-III | OMEGA-CONOTOXINS | VENTILATORY RESPONSES | MUSCULAR-CONTRACTION | arterial pressure | autonomic function | ATTENUATION | RESPIRATORY RESPONSES
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2016, Volume 2016, Issue 21, pp. 3462 - 3472
Conotoxins are disulfide‐rich peptides found in the venoms of marine snails of the genus Conus. They have attracted great attention from the pharmaceutical... 
Drug design | Stability | Cyclization | Conotoxins | Disulfides | GATED SODIUM-CHANNELS | NATIVE CHEMICAL LIGATION | CHEMISTRY, ORGANIC | MU-O-CONOTOXINS | NICOTINIC ACETYLCHOLINE-RECEPTORS | OMEGA-CONOTOXINS | CYCLIC CYSTINE KNOT | CONUS-TEXTILE | CALCIUM-CHANNELS | ALPHA-CONOTOXIN | NOREPINEPHRINE TRANSPORTER
Journal Article
by Ren, J and Li, R and Ning, J and Zhu, XP and Zhangsun, DT and Wu, Y and Luo, SL
MARINE DRUGS, ISSN 1660-3397, 06/2018, Volume 16, Issue 6
alpha-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits alpha 3 beta 4... 
alpha 3 beta 4 nAChR | molecular dynamics simulations | CONUS PEPTIDE LIGAND | VENOM | CHEMISTRY, MEDICINAL | ANTAGONIST | peptide synthesis and activity assay | OMEGA-CONOTOXINS | alpha-Conotoxin TxID | INHIBITION | TARGETS | SUPERFAMILY | methionine oxidation and substitution | CALCIUM-CHANNEL SUBTYPES | TEXTILE | SELECTIVITY
Journal Article