X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (260347) 260347
Book Chapter (683) 683
Dissertation (541) 541
Book / eBook (256) 256
Reference (223) 223
Conference Proceeding (215) 215
Magazine Article (203) 203
Newsletter (173) 173
Publication (169) 169
Government Document (137) 137
Web Resource (90) 90
Newspaper Article (49) 49
Streaming Video (13) 13
Journal / eJournal (12) 12
Book Review (11) 11
Transcript (4) 4
Video Recording (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (171892) 171892
animals (128206) 128206
mice (69033) 69033
male (64270) 64270
female (63610) 63610
oncology (55281) 55281
biochemistry & molecular biology (45088) 45088
apoptosis (44013) 44013
expression (43393) 43393
cell biology (43283) 43283
cancer (35736) 35736
phosphorylation (33565) 33565
signal transduction (33431) 33431
cell line, tumor (33203) 33203
rats (31914) 31914
proto-oncogene proteins c-akt - metabolism (29259) 29259
middle aged (28343) 28343
mutation (27365) 27365
proto-oncogene proteins - genetics (26948) 26948
activation (26453) 26453
proto-oncogene proteins - metabolism (26114) 26114
adult (25130) 25130
cell line (23923) 23923
oncogenes (23893) 23893
cells, cultured (23149) 23149
gene expression (22920) 22920
proteins (22710) 22710
aged (21870) 21870
apoptosis - drug effects (21485) 21485
immunohistochemistry (21449) 21449
molecular sequence data (20825) 20825
research (20486) 20486
proto-oncogene proteins c-bcl-2 - metabolism (17754) 17754
base sequence (17608) 17608
genetic aspects (16805) 16805
gene (16333) 16333
signal transduction - drug effects (16199) 16199
transfection (15906) 15906
cells (15902) 15902
tumors (15894) 15894
protein (15631) 15631
gene expression regulation, neoplastic (15293) 15293
analysis (15247) 15247
cell proliferation (15010) 15010
tumor cells, cultured (14981) 14981
prognosis (14027) 14027
research article (13984) 13984
phosphatidylinositol 3-kinases - metabolism (13907) 13907
genetics & heredity (13613) 13613
neurosciences (13555) 13555
blotting, western (13548) 13548
hematology (13256) 13256
amino acid sequence (13193) 13193
oncogene (13002) 13002
pathology (12293) 12293
gene-expression (12232) 12232
growth (12187) 12187
mice, inbred c57bl (12096) 12096
multidisciplinary sciences (12068) 12068
genes (11727) 11727
protein binding (11267) 11267
gene expression regulation (11130) 11130
cell proliferation - drug effects (11103) 11103
kinases (11046) 11046
rats, sprague-dawley (11015) 11015
rna, messenger - metabolism (10805) 10805
physiological aspects (10761) 10761
proliferation (10710) 10710
time factors (10693) 10693
antineoplastic agents - pharmacology (10580) 10580
rna, messenger - genetics (10382) 10382
cell cycle (10360) 10360
inhibition (10281) 10281
health aspects (9952) 9952
differentiation (9932) 9932
dna-binding proteins - genetics (9925) 9925
survival (9840) 9840
p53 (9740) 9740
dna-binding proteins - metabolism (9704) 9704
reverse transcriptase polymerase chain reaction (9616) 9616
medicine, research & experimental (9602) 9602
immunology (9458) 9458
aged, 80 and over (9379) 9379
down-regulation (9352) 9352
pharmacology & pharmacy (9202) 9202
proto-oncogene proteins c-bcl-2 - genetics (9167) 9167
signal transduction - physiology (9133) 9133
transcription, genetic (9088) 9088
transcription factors - metabolism (8991) 8991
disease models, animal (8988) 8988
akt (8972) 8972
metastasis (8939) 8939
polymerase chain reaction (8920) 8920
in-vivo (8842) 8842
transcription factors - genetics (8809) 8809
transcription factors (8801) 8801
tumor suppressor protein p53 - metabolism (8743) 8743
pathway (8714) 8714
mice, knockout (8610) 8610
bcl-2 (8550) 8550
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (190) 190
Online Resources - Online (90) 90
Collection Dvlpm't (Acquisitions) - Vendor file (12) 12
UofT at Mississauga - Stacks (12) 12
Collection Dvlpm't (Acquisitions) - Closed Orders (10) 10
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (8) 8
UTL at Downsview - May be requested (7) 7
UofT at Scarborough - Stacks (4) 4
Gerstein Science - Periodical Stacks (3) 3
Chemistry (A D Allen) - Stacks (2) 2
Gerstein Science - Bindery (2) 2
Gerstein Science - Circulation Desk (2) 2
Robarts - Stacks (2) 2
St. Michael's Hospital - Circulation Desk (2) 2
St. Michael's Hospital - Stacks (2) 2
Dentistry (Harry R Abbott) - Stacks (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Gerstein Science - Reference (1) 1
Media Commons - Audio Visual (1) 1
Providence Healthcare - Withdrawn (1) 1
Scarborough Hospital - Online (1) 1
UofT at Scarborough - May be requested in 6-10 wks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (257347) 257347
Chinese (4571) 4571
Japanese (2468) 2468
French (1194) 1194
German (732) 732
Russian (710) 710
Spanish (457) 457
Portuguese (297) 297
Polish (210) 210
Italian (103) 103
Korean (99) 99
Hungarian (85) 85
Czech (80) 80
Romanian (50) 50
Norwegian (43) 43
Dutch (42) 42
Ukrainian (24) 24
Turkish (22) 22
Danish (20) 20
Swedish (19) 19
Croatian (17) 17
Finnish (16) 16
Serbian (16) 16
Slovak (16) 16
Persian (11) 11
Bulgarian (9) 9
Hebrew (9) 9
Arabic (3) 3
Latin (3) 3
Welsh (3) 3
Slovenian (2) 2
Bosnian (1) 1
Lithuanian (1) 1
Nauru (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Oncogene, ISSN 0950-9232, 1987
Journal
British journal of clinical pharmacology, ISSN 0306-5251, 2016, Volume 82, Issue 4, pp. 943 - 956
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 10/2013, Volume 188, Issue 7, pp. 770 - 775
The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR... 
Molecular targeted therapy | Lung cancer | Cancer genomics | RET | GEFITINIB | EML4-ALK FUSION GENE | KINASE INHIBITOR | ALK INHIBITOR | SOMATIC MUTATIONS | EGFR | CHEMOTHERAPY | lung cancer | PHASE-II TRIAL | RESPIRATORY SYSTEM | CRIZOTINIB | cancer genomics | molecular targeted therapy | CRITICAL CARE MEDICINE | Lung Neoplasms - drug therapy | Oncogene Proteins - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma of Lung | Receptor, ErbB-2 - genetics | Genomics | Humans | ErbB Receptors - genetics | Antineoplastic Agents - therapeutic use | ErbB Receptors - therapeutic use | Anaplastic Lymphoma Kinase | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | ras Proteins - drug effects | Receptor, ErbB-2 - drug effects | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Proto-Oncogene Proteins - drug effects | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - drug effects | Proto-Oncogene Proteins - genetics | Mutation - genetics | Adenocarcinoma - drug therapy | Oncogene Proteins - drug effects | Proto-Oncogene Proteins c-met - genetics | Mutation - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor Protein-Tyrosine Kinases - therapeutic use | Proto-Oncogene Proteins c-ret - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Proto-Oncogene Proteins c-ret - genetics | Pulmonary
Journal Article
1994, 1, ISBN 0849345731, 310
This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several... 
Proto-Oncogene Proteins c-fos | Transcription factors | genetics | Gene Expression Regulation, Viral | Jun oncogenes | Fos oncogenes | Proto-Oncogene Proteins c-jun | Biochemistry
Book
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2009, Volume 101, Issue 19, pp. 1308 - 1324
The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for... 
CELL LUNG-CANCER | PHASE-III TRIAL | TYROSINE KINASE INHIBITORS | COLON-CANCER | KRAS MUTATIONS | K-RAS MUTATIONS | PROGRESSION-FREE-SURVIVAL | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | IN-SITU HYBRIDIZATION | GENE COPY NUMBER | PTEN Phosphohydrolase - drug effects | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Antibodies, Monoclonal - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Colorectal Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - drug effects | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cetuximab | Odds Ratio | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - drug effects | Antibodies, Monoclonal - pharmacology | Proto-Oncogene Proteins - genetics | Randomized Controlled Trials as Topic | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | Class I Phosphatidylinositol 3-Kinases | Mutation - drug effects | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Colorectal Neoplasms - pathology | Neoplasm Staging | Research Design | Usage | Care and treatment | Prognosis | Gene mutations | Colorectal cancer | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Biological markers | Health aspects | Review
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7326, pp. 968 - 972
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas(1). Pre-clinical studies have... 
TRANSFORMATION | CELLS | ACTIVATION | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRAF | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 58, Issue 6, pp. 1028 - 1039
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well... 
SELECTIVE-INHIBITION | RECRUITMENT | C/EBP-ALPHA | CREB-BINDING PROTEIN | CHROMATIN | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | P-TEFB | BRD4 | CELL BIOLOGY | Transcriptional Regulator ERG | NIH 3T3 Cells | Oncogene Proteins - genetics | Humans | Leukemia, Myeloid - genetics | Proto-Oncogene Proteins c-myb - genetics | Gene Expression Profiling | Leukemia, Myeloid - pathology | RNA Interference | Proto-Oncogene Protein c-fli-1 - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Acute Disease | Proto-Oncogene Protein c-fli-1 - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Acetylation - drug effects | Animals | Hematopoietic System - metabolism | Leukemia, Myeloid - metabolism | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Histones - metabolism | DNA binding proteins | Medicine, Experimental | Medical research | Chromatin | Lysine
Journal Article
Lung Cancer, ISSN 0169-5002, 2014, Volume 86, Issue 3, pp. 324 - 328
Highlights • We investigated the presence of mutations in a panel of 6 genes in 113 SCLCs. • We could identify only 7 mutations, 2 in EGFR and 5 in c-MET gene.... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | SCLC | PDGFRa | Gene mutations | c-KIT | c-MET | BRAF | KRAS | EGFR | C-MET | C-KIT | GEFITINIB | EGFR MUTATION | TRIAL | ONCOLOGY | RESPIRATORY SYSTEM | FACTOR RECEPTOR MUTATIONS | JAPANESE | CARCINOMA | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins c-met - biosynthesis | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Molecular Targeted Therapy | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-kit - biosynthesis | Receptor, Platelet-Derived Growth Factor beta - genetics | Small Cell Lung Carcinoma - drug therapy | ras Proteins - biosynthesis | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Receptor, Epidermal Growth Factor - biosynthesis | Proto-Oncogene Proteins - genetics | Small Cell Lung Carcinoma - genetics | Proto-Oncogene Proteins c-met - genetics | Disease-Free Survival | Small Cell Lung Carcinoma - pathology | Proto-Oncogene Proteins B-raf - biosynthesis | Proto-Oncogene Proteins B-raf - genetics | Aged | Mutation | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Lung cancer | Genes | Genetic research | Genetic aspects | Diagnosis | Cervical cancer | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 493 - 506
MYCN amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article