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Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 427 - 430
Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 04/2014, Volume 232, Issue 5, pp. 492 - 498
Ameloblastoma is a benign but locally infiltrative odontogenic neoplasm. Although ameloblastomas rarely metastasise, recurrences together with radical surgery... 
targeted therapy | odontogenic tumour | BRAF | oncogenic mutation | EGFR | ameloblastoma | GEFITINIB | TRANSGENIC MOUSE | PATHOLOGY | METASTATIC COLORECTAL-CANCER | PANITUMUMAB | LUNG-CANCER | ONCOLOGY | FACTOR RECEPTOR EXPRESSION | KRAS | EGF RECEPTOR | CELL-LINE | ERLOTINIB | Ameloblastoma - drug therapy | Receptor, Epidermal Growth Factor - genetics | Jaw Neoplasms - drug therapy | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Ameloblastoma - enzymology | Molecular Targeted Therapy | Jaw Neoplasms - pathology | Patient Selection | Dose-Response Relationship, Drug | Young Adult | Receptor, Epidermal Growth Factor - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Ameloblastoma - pathology | Antineoplastic Agents - pharmacology | Jaw Neoplasms - enzymology | Proto-Oncogene Proteins B-raf - metabolism | Cell Survival - drug effects | Genetic Predisposition to Disease | Gene Frequency | Ameloblastoma - genetics | Phenotype | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Adolescent | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | Mutation | Receptor, ErbB-4 | Jaw Neoplasms - genetics | Immunohistochemistry | Genetic aspects | Gene mutations | Analysis | Pathogenesis | Original Papers
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 12/2011, Volume 17, Issue 24, pp. 7595 - 7604
Purpose: Malignant astrocytomas (MA) are aggressive central nervous system tumors with poor prognosis. Activating mutation of BRAF (BRAF(V600E)) has been... 
ONCOGENIC RAS | ONCOLOGY | DIAGNOSED GLIOBLASTOMA-MULTIFORME | WILD-TYPE BRAF | TYROSINE KINASES | B-RAF | MELANOMA-CELLS | HIGH-GRADE GLIOMAS | PHARMACOLOGICAL INHIBITION | EGFR AMPLIFICATION | RADIATION-THERAPY
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29336
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 07/2011, Volume 8, Issue 7, pp. 426 - 433
Journal Article
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 2006, Volume 17, Issue 1, pp. 31 - 39
Journal Article
Journal Article
Journal Article