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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2015, Volume 112, Issue 21, pp. 6625 - 6630
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 15, pp. 12924 - 12932
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e44146 - e44146
Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no therapies exist targeting this oncogene. K-RAS signals via... 
BREAST-CANCER | SIGNALING PATHWAYS | CANCER CELLS | ONCOGENIC RAS | DUCTAL ADENOCARCINOMA | VASCULATURE | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | KINASE | GROWTH | ANTITUMOR-ACTIVITY | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Gene Knockdown Techniques | Mitogen-Activated Protein Kinase Kinases - metabolism | HEK293 Cells | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Mutation - genetics | Sulfonamides - pharmacology | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Models, Biological | Cell Line, Tumor | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Ras genes | Gene mutations | Pancreatic cancer | Physiological aspects | Genetic aspects | Research | Risk factors | Drugs | Biomedical research | Disease | Clinical trials | Oncology | Drug delivery | Kinases | Cancer therapies | K-Ras protein | Signal transduction | Pathways | Cell cycle | Xenografts | Tumorigenesis | Inhibition | Medical research | MAP kinase | Data processing | Breast cancer | Maintenance | 1-Phosphatidylinositol 3-kinase | Signaling | Models | In vivo methods and tests | Mutation | Tumors | Cancer | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 243 - 256
Mutations in are prevalent in human cancers and universally predictive of resistance to anticancer therapeutics. Although it is widely accepted that... 
ACTIVATION | INHIBITION | ONCOGENIC RAS | TUMOR PROGRESSION | CHK1 | ONCOLOGY | INITIATION | COMBINATION | SUPPRESSION | ATR | KINASES | CELL BIOLOGY | Neoplasms - metabolism | Protein Kinases - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | ras Proteins - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | GTP Phosphohydrolases - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Flow Cytometry | Neoplasms - genetics | DNA Damage - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | DNA Damage - drug effects | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | GTP Phosphohydrolases - genetics | Mice, Nude | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Checkpoint Kinase 1 | Mice | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Chemotherapy | DNA damage | DNA | Genetic research | DNA repair | Cancer | Tumors | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2017, Volume 27, Issue 12, pp. 2757 - 2761
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5267 - 5280
Purpose: Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased... 
GASTRIN | ACTIVATION | INHIBITION | METASTASIS | ONCOGENIC RAS | ONCOLOGY | SIGNALING PATHWAY | GROWTH | RESISTANCE | THERAPIES | EXPRESSION | Protein Precursors - blood | Neoplastic Stem Cells - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Neoplasm Recurrence, Local - drug therapy | Neoplasm Recurrence, Local - pathology | Protein Precursors - antagonists & inhibitors | Antibodies, Anti-Idiotypic - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Colorectal Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Gastrins - blood | Antibodies, Anti-Idiotypic - immunology | Gastrins - antagonists & inhibitors | Protein Precursors - immunology | Gastrins - immunology | HT29 Cells | Animals | Wnt Signaling Pathway - drug effects | Neoplasm Recurrence, Local - genetics | Cell Proliferation - drug effects | Mice | Mutation | Colorectal Neoplasms - pathology | Wnt protein | Colorectal carcinoma | Colorectal cancer | Medical services | Antibodies | Stem cell transplantation | Raf protein | Cancer therapies | K-Ras protein | Metastases | β-catenin | Allografts | Intestine | Colon | Immunoglobulins | Cell survival | Therapeutic applications | Transgenic mice | Tumor cell lines | Cell differentiation | Patients | Signaling | Chemotherapy | Lymphocytes B | Experimental design | Cell lines | Stem cells | Monoclonal antibodies | Cell migration | Tumors | Cancer | Index Medicus | Life Sciences
Journal Article
Blood, ISSN 0006-4971, 06/2013, Volume 121, Issue 24, pp. 4884 - 4893
Journal Article