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Structure, ISSN 0969-2126, 09/2017, Volume 25, Issue 9, pp. 1323 - 1324
Mutations in members of the RAS family of small GTPases have been associated with numerous human cancers. However, RAS family members are notoriously difficult... 
ONCOGENIC K-RAS | SITE INHIBITOR | BIOPHYSICS | SMALL MOLECULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Deuterium | ras Proteins - genetics | Hydrogen | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Mass Spectrometry | Mutation | G proteins | Index Medicus
Journal Article
Journal Article
Journal Article
Cell, ISSN 0092-8674, 01/2018, Volume 172, Issue 3, pp. 578 - 589.e17
Journal Article
Science Translational Medicine, ISSN 1946-6234, 06/2017, Volume 9, Issue 394, p. eaal5253
Activating mutations in KRAS underlie the pathogenesis of up to 20% of human tumors, and KRAS is one of the most frequently mutated genes in cancer. Developing... 
LUNG ADENOCARCINOMAS | MEDICINE, RESEARCH & EXPERIMENTAL | K-RAS | MEK INHIBITION | SMALL MOLECULES | ONCOGENIC KRAS | PANCREATIC-CANCER | GROWTH | DRUG DEVELOPMENT | SIRNA | MUTANT KRAS | CELL BIOLOGY | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2012, Volume 22, Issue 3, pp. 304 - 317
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2017, Volume 56, Issue 9, pp. 2423 - 2428
Small‐molecule inhibition of the interaction between the KRas oncoprotein and the chaperone PDE6δ impairs KRas spatial organization and signaling in cells.... 
Ras protein | drug design | structure–activity relationships | PDEδ | medicinal chemistry | ACTIVATION | NUCLEOTIDE EXCHANGE | SMALL MOLECULES | PDE delta | ONCOGENIC KRAS | IDENTIFICATION | PLASMA-MEMBRANE | RAS ONCOGENES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | structure-activity relationships | K-RAS | MODULATION
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 2019, Volume 186, Issue 3, p. e52
Journal Article