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Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 305 - 331
... )-2-hydroxyglutarate (2-HG) by mutant IDH1 and IDH2 (mIDH). Heterozygous mutation of IDH1 2 and accumulation... 
cancer therapeutics | allosteric inhibition | metabolism | oncometabolite | Allosteric inhibition | Cancer therapeutics | Metabolism | Oncometabolite | Glutarates - analysis | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Benzeneacetamides - chemical synthesis | Acetamides - chemical synthesis | Leukemia, Myeloid, Acute - enzymology | Benzeneacetamides - therapeutic use | Acetamides - therapeutic use | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Benzimidazoles - therapeutic use | Gene Expression | Biomarkers, Tumor - analysis | Isoenzymes - genetics | Leukemia, Myeloid, Acute - pathology | Benzimidazoles - chemical synthesis | Translational Medical Research | Small Molecule Libraries - therapeutic use | Models, Molecular | Small Molecule Libraries - chemical synthesis | Isocitrate Dehydrogenase - genetics | Drug Discovery | Enzyme Inhibitors - therapeutic use | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mutation | Isoenzymes - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Gene mutations | Physiological aspects | Genetic aspects | Oxidoreductases | Research | Antineoplastic agents | Phosphates | Circuits | Leukemia | Glioblastoma | Differentiation (biology) | Clinical trials | Drug development | Dehydrogenase | Crystallography | Carcinogenesis | Carcinogens | Allosteric properties | Inhibition | Isocitrate dehydrogenase | Cholangiocarcinoma | Enzymes | Medical research | NADPH-diaphorase | Myeloid leukemia | Adenine | Isoforms | Nicotinamide adenine dinucleotide | Nicotinamide | Drug discovery | Acute myeloid leukemia | Cellular structure | Index Medicus
Journal Article
Journal of experimental & clinical cancer research, ISSN 1756-9966, 06/2017, Volume 36, Issue 1, pp. 74 - 74
Journal Article
Journal Article
Journal Article
Acta pharmacologica Sinica, ISSN 1745-7254, 04/2019, Volume 40, Issue 10, pp. 1292 - 1302
.... Mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2) frequently occur in gliomas, which leads to accumulation of oncometabolic product 2-hydroxyglutarate (2HG... 
Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | AMP-Activated Protein Kinases - metabolism | NF-kappa B - antagonists & inhibitors | Microglia - drug effects | TOR Serine-Threonine Kinases - metabolism | AMP-Activated Protein Kinases - antagonists & inhibitors | Humans | Cells, Cultured | NF-kappa B - metabolism | Structure-Activity Relationship | Lipopolysaccharides - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | HEK293 Cells | Lipopolysaccharides - pharmacology | Mice | Glutarates - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | TOR protein | Phosphorylation | Transcription | Genes | Interleukin | Central nervous system | Kinases | Macrophages | Lipopolysaccharides | Interleukin 6 | Signal transduction | Cell activation | Glioma cells | Tumor necrosis factor-TNF | Pretreatment | Conditioning | Isocitrate dehydrogenase | Immune system | Carbon-carbon composites | Translocation | NF-κB protein | AMP | Rapamycin | Inflammation | Tumor necrosis factor-α | Gene expression | IL-1β | Nuclear transport | Microglia | Signaling | Protein kinase | Adenosine kinase | CXCL10 protein | Mutation | Chemokines | Monocyte chemoattractant protein 1 | Index Medicus | NF-κB | inflammation | 2-Hydroxyglutarate | mTOR | glioma | AMPK | oncometabolite | BAY11-7082 | microglia
Journal Article